PMID- 30132802 OWN - NLM STAT- MEDLINE DCOM- 20191011 LR - 20191011 IS - 1600-0447 (Electronic) IS - 0001-690X (Linking) VI - 138 IP - 5 DP - 2018 Nov TI - Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis. PG - 432-440 LID - 10.1111/acps.12944 [doi] AB - OBJECTIVE: Accumulating evidence implicates immune activation in the development of schizophrenia. Here, monocyte numbers, monocyte chemoattractant protein-1 (MCP-1) and chitinase-3-like protein 1 (YKL-40) were investigated in plasma and cerebrospinal fluid (CSF) in first-episode psychosis (FEP) patients. METHOD: CSF and blood were sampled from 42 first-episode psychosis (FEP) patients and 22 healthy controls. The levels of YKL-40 and MCP-1 were measured using electrochemiluminescence assay, and blood monocytes were counted using an XN-9000-hematology analyzer. RESULTS: We found higher plasma levels of MCP-1 and YKL-40 in FEP patients compared with healthy controls, a condition that was unrelated to antipsychotic and/or anxiolytic medication. This was combined with an increased number of blood monocytes and a borderline significant increase in YKL-40 levels in the CSF of tobacco-free FEP patients. Plasma or CSF chemokines or blood monocytes did not correlate with the severity of symptoms or the level of functioning. CONCLUSION: These data demonstrate activation of monocytes in FEP and strengthens the idea of an immune dysfunction of psychotic disorders. Further studies are required to perceive a role of YKL-40 and MCP-1 in the initiation and progression of schizophrenia. CI - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Orhan, F AU - Orhan F AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. FAU - Schwieler, L AU - Schwieler L AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. FAU - Fatouros-Bergman, H AU - Fatouros-Bergman H AD - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. FAU - Malmqvist, A AU - Malmqvist A AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. FAU - Cervenka, S AU - Cervenka S AD - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. FAU - Collste, K AU - Collste K AD - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. FAU - Flyckt, L AU - Flyckt L AD - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. FAU - Farde, L AU - Farde L AD - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden. AD - PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, Stockholm, Sweden. FAU - Sellgren, C M AU - Sellgren CM AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, USA. AD - Center for Experimental Drugs and Diagnostics, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. AD - Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. FAU - Piehl, F AU - Piehl F AD - Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. CN - Karolinska Schizophrenia Project (KaSP) Consortium FAU - Engberg, G AU - Engberg G AUID- ORCID: 0000-0003-1659-5232 AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. FAU - Erhardt, S AU - Erhardt S AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. LA - eng GR - KID-funding from the Karolinska Institutet/International GR - Petrus och Augusta Hedlunds Stiftelse/International GR - Ahlen-siftelsen/International GR - Soderbergs Konigska Stiftelse/International GR - Marta Lundqvists Stiftelse/International GR - Stiftelsen Professor Bror Gadelius Minnesfond/International GR - the AstraZeneca-Karolinska Institutet Joint Research Program in Translational Science/International GR - Stockholm County Council (ALF, PPG)/International GR - Torsten Soderbergs Stiftelse/International GR - Knut och Alice Wallenbergs Stiftelse/International GR - the Swedish Medical Research Council/International GR - Svenska Lakaresallskapet/International GR - Psykiatrifonden/International GR - the Swedish Brain Foundation/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180821 PL - United States TA - Acta Psychiatr Scand JT - Acta psychiatrica Scandinavica JID - 0370364 RN - 0 (CCL2 protein, human) RN - 0 (CHI3L1 protein, human) RN - 0 (Chemokine CCL2) RN - 0 (Chitinase-3-Like Protein 1) SB - IM MH - Adult MH - Chemokine CCL2/*blood/cerebrospinal fluid MH - Chitinase-3-Like Protein 1/*blood/cerebrospinal fluid MH - Female MH - Humans MH - Leukocyte Count MH - Male MH - *Monocytes MH - Psychotic Disorders/*blood/cerebrospinal fluid/immunology MH - Schizophrenia/*blood/cerebrospinal fluid/immunology MH - Young Adult OTO - NOTNLM OT - first-episode psychosis OT - neuroimmunology OT - schizophrenia FIR - Hedberg, Mikael IR - Hedberg M FIR - Victorsson, Pauliina IR - Victorsson P EDAT- 2018/08/23 06:00 MHDA- 2019/10/12 06:00 CRDT- 2018/08/23 06:00 PHST- 2018/07/10 00:00 [accepted] PHST- 2018/08/23 06:00 [pubmed] PHST- 2019/10/12 06:00 [medline] PHST- 2018/08/23 06:00 [entrez] AID - 10.1111/acps.12944 [doi] PST - ppublish SO - Acta Psychiatr Scand. 2018 Nov;138(5):432-440. doi: 10.1111/acps.12944. Epub 2018 Aug 21.