PMID- 30134124
OWN - NLM
STAT- MEDLINE
DCOM- 20200708
LR  - 20220402
IS  - 1545-4304 (Electronic)
IS  - 0362-1642 (Print)
IS  - 0362-1642 (Linking)
VI  - 59
DP  - 2019 Jan 6
TI  - Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding 
      Immune-Mediated Adverse Drug Reactions.
PG  - 463-486
LID - 10.1146/annurev-pharmtox-010818-021818 [doi]
AB  - Adverse drug reactions (ADRs) are a significant health care burden. 
      Immune-mediated adverse drug reactions (IM-ADRs) are responsible for one-fifth of 
      ADRs but contribute a disproportionately high amount of that burden due to their 
      severity. Variation in human leukocyte antigen ( HLA) genes has emerged as a 
      potential preprescription screening strategy for the prevention of previously 
      unpredictable IM-ADRs. Immunopharmacogenomics combines the disciplines of 
      immunogenomics and pharmacogenomics and focuses on the effects of immune-specific 
      variation on drug disposition and IM-ADRs. In this review, we present the latest 
      evidence for HLA associations with IM-ADRs, ongoing research into biological 
      mechanisms of IM-ADRs, and the translation of clinical actionable biomarkers for 
      IM-ADRs, with a focus on T cell-mediated ADRs.
FAU - Karnes, Jason H
AU  - Karnes JH
AD  - Department of Pharmacy Practice and Science, University of Arizona College of 
      Pharmacy, Tucson, Arizona 85721, USA.
AD  - Sarver Heart Center, University of Arizona College of Medicine, Tucson, Arizona 
      85724, USA.
AD  - Division of Pharmacogenomics, Center for Applied Genetics and Genomic Medicine 
      (TCAG2M), Tucson, Arizona 85721, USA.
FAU - Miller, Matthew A
AU  - Miller MA
AD  - Department of Pharmacy Practice and Science, University of Arizona College of 
      Pharmacy, Tucson, Arizona 85721, USA.
FAU - White, Katie D
AU  - White KD
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, 
      Tennessee 37232, USA; email: elizabeth.j.phillips@vanderbilt.edu.
FAU - Konvinse, Katherine C
AU  - Konvinse KC
AD  - Department of Pathology, Microbiology, and Immunology, Vanderbilt University 
      Medical Center, Nashville, Tennessee 37232, USA.
AD  - Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
FAU - Pavlos, Rebecca K
AU  - Pavlos RK
AD  - Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, 
      Subiaco, Western Australia 6008, Australia.
AD  - Institute for Immunology and Infectious Diseases, Murdoch University, Perth, 
      Western Australia 6150, Australia.
FAU - Redwood, Alec J
AU  - Redwood AJ
AD  - Institute for Immunology and Infectious Diseases, Murdoch University, Perth, 
      Western Australia 6150, Australia.
FAU - Peter, Jonathan G
AU  - Peter JG
AD  - Division of Allergy and Clinical Immunology, Department of Medicine, University 
      of Cape Town, Cape Town 7925, South Africa.
AD  - Division of Dermatology, Department of Medicine, University of Cape Town, Cape 
      Town 7925, South Africa.
FAU - Lehloenya, Rannakoe
AU  - Lehloenya R
AD  - Division of Allergy and Clinical Immunology, Department of Medicine, University 
      of Cape Town, Cape Town 7925, South Africa.
FAU - Mallal, Simon A
AU  - Mallal SA
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, 
      Tennessee 37232, USA; email: elizabeth.j.phillips@vanderbilt.edu.
AD  - Department of Pathology, Microbiology, and Immunology, Vanderbilt University 
      Medical Center, Nashville, Tennessee 37232, USA.
AD  - Institute for Immunology and Infectious Diseases, Murdoch University, Perth, 
      Western Australia 6150, Australia.
FAU - Phillips, Elizabeth J
AU  - Phillips EJ
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, 
      Tennessee 37232, USA; email: elizabeth.j.phillips@vanderbilt.edu.
AD  - Department of Pathology, Microbiology, and Immunology, Vanderbilt University 
      Medical Center, Nashville, Tennessee 37232, USA.
AD  - Institute for Immunology and Infectious Diseases, Murdoch University, Perth, 
      Western Australia 6150, Australia.
LA  - eng
GR  - K43 TW011178/TW/FIC NIH HHS/United States
GR  - R34 AI136815/AI/NIAID NIH HHS/United States
GR  - P50 GM115305/GM/NIGMS NIH HHS/United States
GR  - P30 AI110527/AI/NIAID NIH HHS/United States
GR  - R21 AI139021/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180822
PL  - United States
TA  - Annu Rev Pharmacol Toxicol
JT  - Annual review of pharmacology and toxicology
JID - 7607088
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Drug Hypersensitivity/immunology/prevention & control
MH  - Drug-Related Side Effects and Adverse Reactions/*immunology/*prevention & control
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Pharmacogenetics/methods
MH  - T-Lymphocytes/immunology
PMC - PMC6409210
MID - NIHMS986628
OTO - NOTNLM
OT  - Stevens-Johnson syndrome
OT  - adverse drug reaction
OT  - human leukocyte antigen
OT  - immunopharmacogenomics
OT  - pharmacogenomics
OT  - toxic epidermal necrolysis
EDAT- 2018/08/23 06:00
MHDA- 2020/07/09 06:00
PMCR- 2019/03/10
CRDT- 2018/08/23 06:00
PHST- 2018/08/23 06:00 [pubmed]
PHST- 2020/07/09 06:00 [medline]
PHST- 2018/08/23 06:00 [entrez]
PHST- 2019/03/10 00:00 [pmc-release]
AID - 10.1146/annurev-pharmtox-010818-021818 [doi]
PST - ppublish
SO  - Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:463-486. doi: 
      10.1146/annurev-pharmtox-010818-021818. Epub 2018 Aug 22.