PMID- 30134168
OWN - NLM
STAT- MEDLINE
DCOM- 20200127
LR  - 20200127
IS  - 2211-1247 (Electronic)
VI  - 24
IP  - 8
DP  - 2018 Aug 21
TI  - A BDNF-Mediated Push-Pull Plasticity Mechanism for Synaptic Clustering.
PG  - 2063-2074
LID - S2211-1247(18)31191-4 [pii]
LID - 10.1016/j.celrep.2018.07.073 [doi]
AB  - During development, activity-dependent synaptic plasticity refines neuronal 
      networks with high precision. For example, spontaneous activity helps sorting 
      synaptic inputs with similar activity patterns into clusters to enhance neuronal 
      computations in the mature brain. Here, we show that TrkB activation and 
      postsynaptic brain-derived neurotrophic factor (BDNF) are required for synaptic 
      clustering in developing hippocampal neurons. Moreover, BDNF and TrkB modulate 
      transmission at synapses depending on their clustering state, indicating that 
      endogenous BDNF/TrkB signaling stabilizes locally synchronized synapses. 
      Together with our previous data on proBDNF/p75(NTR) signaling, these findings 
      suggest a push-pull plasticity mechanism for synaptic clustering: BDNF stabilizes 
      clustered synapses while proBDNF downregulates out-of-sync synapses. This idea is 
      supported by our observation that synaptic clustering requires 
      matrix-metalloproteinase-9 activity, a proBDNF-to-BDNF converting enzyme. 
      Finally, NMDA receptor activation mediates out-of-sync depression upstream of 
      proBDNF signaling. Together, these data delineate an efficient plasticity 
      mechanism where proBDNF and mature BDNF establish synaptic clustering through 
      antagonistic modulation of synaptic transmission.
CI  - Copyright (c) 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Niculescu, Dragos
AU  - Niculescu D
AD  - Department of Synapse and Network Development, Netherlands Institute for 
      Neuroscience, 1105 Amsterdam, the Netherlands; Department of Neurogenesis and 
      Circuit Development, Vision Institute, 75012 Paris, France.
FAU - Michaelsen-Preusse, Kristin
AU  - Michaelsen-Preusse K
AD  - Department of Synapse and Network Development, Netherlands Institute for 
      Neuroscience, 1105 Amsterdam, the Netherlands.
FAU - Guner, Ulku
AU  - Guner U
AD  - Department of Synapse and Network Development, Netherlands Institute for 
      Neuroscience, 1105 Amsterdam, the Netherlands.
FAU - van Dorland, Rene
AU  - van Dorland R
AD  - Department of Biology, Faculty of Science, Utrecht University, 3584 Utrecht, the 
      Netherlands.
FAU - Wierenga, Corette J
AU  - Wierenga CJ
AD  - Department of Biology, Faculty of Science, Utrecht University, 3584 Utrecht, the 
      Netherlands.
FAU - Lohmann, Christian
AU  - Lohmann C
AD  - Department of Synapse and Network Development, Netherlands Institute for 
      Neuroscience, 1105 Amsterdam, the Netherlands; Department of Functional Genomics, 
      Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, the 
      Netherlands. Electronic address: c.lohmann@nin.knaw.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Mice
MH  - Neuronal Plasticity/*physiology
MH  - Synapses/*metabolism
OTO - NOTNLM
OT  - BDNF
OT  - MMP9
OT  - NMDAR
OT  - TrkB
OT  - development
OT  - hippocampus
OT  - postsynaptic
OT  - proBDNF
OT  - synaptic clustering
EDAT- 2018/08/23 06:00
MHDA- 2020/01/28 06:00
CRDT- 2018/08/23 06:00
PHST- 2017/10/12 00:00 [received]
PHST- 2018/06/12 00:00 [revised]
PHST- 2018/07/23 00:00 [accepted]
PHST- 2018/08/23 06:00 [entrez]
PHST- 2018/08/23 06:00 [pubmed]
PHST- 2020/01/28 06:00 [medline]
AID - S2211-1247(18)31191-4 [pii]
AID - 10.1016/j.celrep.2018.07.073 [doi]
PST - ppublish
SO  - Cell Rep. 2018 Aug 21;24(8):2063-2074. doi: 10.1016/j.celrep.2018.07.073.