PMID- 30134242
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20190114
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 177
IP  - 4
DP  - 2018
TI  - miR-146a Mimics Attenuate Allergic Airway Inflammation by Impacted Group 2 Innate 
      Lymphoid Cells in an Ovalbumin-Induced Asthma Mouse Model.
PG  - 302-310
LID - 10.1159/000491438 [doi]
AB  - BACKGROUND: The prevalence of allergic asthma has increased dramatically. 
      Previous studies have found that the microRNA 146a (miR-146a) expression in 
      asthma inhibits cell proliferation and promotes apoptosis of bronchial smooth 
      muscle cells. We aimed to investigate the effect of miR-146a mimics on ovalbumin 
      (OVA)-induced asthma in a mouse model. METHODS: Inflammatory cell infiltration in 
      bronchoalveolar lavage fluid (BALF) was measured by flow cytometry. Levels of 
      OVA-specific immunoglobulin E (IgE) in serum and cytokines in BALF were examined 
      by enzyme-linked immunosorbent assay. For monitoring the airway, the Penh value 
      (% baseline) was measured using a whole-body plethysmograph. RESULTS: In 
      OVA-induced asthmatic mice, miR-146a significantly suppressed the infiltration of 
      inflammatory cells in BALF and decreased the levels of OVA-specific IgE and T 
      helper 2 cell type cytokines. In addition, miR-146a inhibited the OVA-induced 
      airway hyperresponsiveness and the group 2 innate lymphoid cell responses. 
      Moreover, the effects of miR-146a mimics were dependent on interleukin 33 
      stimulation. CONCLUSIONS: Our results suggest that miR-146a mimics might serve as 
      an attractive candidate for further preclinical studies as an anti-inflammatory 
      treatment of asthma.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Han, Shuguang
AU  - Han S
AD  - Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - Department of Respiratory Medicine, the Affiliated Wuxi No. 2 People's Hospital 
      of Nanjing Medical University, Wuxi, China.
FAU - Ma, Chenhui
AU  - Ma C
AD  - Department of Respiratory Medicine, the Affiliated Wuxi No. 2 People's Hospital 
      of Nanjing Medical University, Wuxi, China.
FAU - Bao, Liang
AU  - Bao L
AD  - Department of Respiratory Medicine, the Affiliated Wuxi No. 2 People's Hospital 
      of Nanjing Medical University, Wuxi, China.
FAU - Lv, Lei
AU  - Lv L
AD  - Department of Respiratory Medicine, the Affiliated Wuxi No. 2 People's Hospital 
      of Nanjing Medical University, Wuxi, China.
FAU - Huang, Mao
AU  - Huang M
AD  - Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, Chinahuangmao2009@126.com.
LA  - eng
PT  - Journal Article
DEP - 20180822
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Interleukin-33)
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn146 microRNA, mouse)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Asthma/*genetics/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*genetics/immunology
MH  - Immunoglobulin E/blood
MH  - Inflammation/*genetics/immunology
MH  - Interleukin-33/metabolism
MH  - Lymphocytes/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - MicroRNAs/*genetics
MH  - Ovalbumin/immunology
MH  - Th2 Cells/immunology
OTO - NOTNLM
OT  - Airway hyperresponsiveness
OT  - Group 2 innate lymphoid cells
OT  - Interleukin 33
OT  - MicroRNA 146a
OT  - T helper 2 cell type cytokines
EDAT- 2018/08/23 06:00
MHDA- 2019/01/15 06:00
CRDT- 2018/08/23 06:00
PHST- 2018/04/08 00:00 [received]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/08/23 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/08/23 06:00 [entrez]
AID - 000491438 [pii]
AID - 10.1159/000491438 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2018;177(4):302-310. doi: 10.1159/000491438. Epub 2018 
      Aug 22.