PMID- 30135606
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20190503
IS  - 1476-5489 (Electronic)
IS  - 0955-9930 (Linking)
VI  - 31
IP  - 1
DP  - 2019 Jan
TI  - Effect of testosterone replacement therapy on sexual function and glycemic 
      control among hypogonadal men with type 2 diabetes mellitus.
PG  - 25-30
LID - 10.1038/s41443-018-0065-z [doi]
AB  - We investigated the effect of testosterone replacement therapy (TRT) on glycemic 
      control and sexual function among hypogonadal men with type 2 diabetes mellitus 
      (T2DM). From the EARTH study, 86 patients (47 in the TRT and 39 in the non-TRT 
      groups) with a diagnosis of T2DM were extracted. We collected data on waist 
      circumference, body mass index, body fat volume, free testosterone, hemoglobin 
      (Hb), fasting blood sugar, and hemoglobin A1c (HbA1c) at baseline and after 12 
      months. Aging Male Symptoms (AMS) score and International Prostate Symptom Score 
      were obtained. Sexual function was assessed by questions 15 (sexual ability), 16 
      (morning erections), and 17 (sexual desire) of AMS subscores. The TRT group 
      received intramuscular testosterone enanthate (250 mg) injections every 4 weeks 
      for 12 months. Body fat percentage, Hb, and HbA1c were significantly improved in 
      the TRT group. In addition, sexual ability and frequency, and sexual desire 
      showed a significant improvement in the TRT group after 1 year TRT. On the other 
      hand, any parameters including glycemic control and sexual functions were not 
      significantly improved in non-TRT groups. One-year TRT can improve sexual 
      function and glycemic control among hypogonadal men with T2DM.
FAU - Shigehara, Kazuyoshi
AU  - Shigehara K
AD  - Department of Integrative Cancer Therapy and Urology, Kanazawa University 
      Graduate School of Medical Science, Kanazawa, Ishikawa, Japan. 
      kshigehara0415@yahoo.co.jp.
FAU - Konaka, Hiroyuki
AU  - Konaka H
AD  - Department of Urology, Kanazawa Red Cross Hospital, Kanazawa, Ishikawa, Japan.
FAU - Kato, Yuki
AU  - Kato Y
AD  - Department of Integrative Cancer Therapy and Urology, Kanazawa University 
      Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
FAU - Iijima, Masashi
AU  - Iijima M
AD  - Department of Integrative Cancer Therapy and Urology, Kanazawa University 
      Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
FAU - Nakashima, Kazufumi
AU  - Nakashima K
AD  - Department of Integrative Cancer Therapy and Urology, Kanazawa University 
      Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
FAU - Kawaguchi, Shohei
AU  - Kawaguchi S
AD  - Department of Integrative Cancer Therapy and Urology, Kanazawa University 
      Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
FAU - Nohara, Takahiro
AU  - Nohara T
AD  - Department of Integrative Cancer Therapy and Urology, Kanazawa University 
      Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
FAU - Izumi, Kouji
AU  - Izumi K
AD  - Department of Integrative Cancer Therapy and Urology, Kanazawa University 
      Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
FAU - Namiki, Mikio
AU  - Namiki M
AD  - Department of Urology, Hasegawa Hospital, Toyama, Japan.
FAU - Mizokami, Atsushi
AU  - Mizokami A
AD  - Department of Integrative Cancer Therapy and Urology, Kanazawa University 
      Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180822
PL  - England
TA  - Int J Impot Res
JT  - International journal of impotence research
JID - 9007383
RN  - 0 (Blood Glucose)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Aged
MH  - *Blood Glucose
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - *Hormone Replacement Therapy
MH  - Humans
MH  - Hypogonadism/blood/complications/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Sexual Dysfunction, Physiological/blood/complications/*drug therapy
MH  - Testosterone/*therapeutic use
MH  - Treatment Outcome
EDAT- 2018/08/24 06:00
MHDA- 2019/05/06 06:00
CRDT- 2018/08/24 06:00
PHST- 2018/05/08 00:00 [received]
PHST- 2018/08/06 00:00 [accepted]
PHST- 2018/06/11 00:00 [revised]
PHST- 2018/08/24 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2018/08/24 06:00 [entrez]
AID - 10.1038/s41443-018-0065-z [pii]
AID - 10.1038/s41443-018-0065-z [doi]
PST - ppublish
SO  - Int J Impot Res. 2019 Jan;31(1):25-30. doi: 10.1038/s41443-018-0065-z. Epub 2018 
      Aug 22.