PMID- 30135925
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2451-8301 (Electronic)
IS  - 2451-8301 (Linking)
VI  - 1
DP  - 2016 Dec
TI  - BDNF trafficking and signaling impairment during early neurodegeneration is 
      prevented by moderate physical activity.
PG  - 19-31
LID - 10.1016/j.ibror.2016.08.001 [doi]
AB  - Physical exercise can attenuate the effects of aging on the central nervous 
      system by increasing the expression of neurotrophins such as brain-derived 
      neurotrophic factor (BDNF), which promotes dendritic branching and enhances 
      synaptic machinery, through interaction with its receptor TrkB. TrkB receptors 
      are synthesized in the cell body and are transported to the axonal terminals and 
      anchored to plasma membrane, through SLP1, CRMP2 and Rab27B, associated with 
      KIF1B. Retrograde trafficking is made by EDH-4 together with dynactin and dynein 
      molecular motors. In the present study it was found that early neurodegeneration 
      is accompanied by decrease in BDNF signaling, in the absence of 
      hyperphosphorylated tau aggregation, in hippocampus of 11 months old Lewis rats 
      exposed to rotenone. It was also demonstrated that moderate physical activity 
      (treadmill running, during 6 weeks, concomitant to rotenone exposure) prevents 
      the impairment of BDNF system in aged rats, which may contribute to delay 
      neurodegeneration. In conclusion, decrease in BDNF and TrkB vesicles occurs 
      before large aggregate-like p-Tau are formed and physical activity applied during 
      early neurodegeneration may be of relevance to prevent BDNF system decay.
FAU - Almeida, Michael F
AU  - Almeida MF
AD  - Department of Genetics and Evolutionary Biology, Institute for Biosciences, 
      University of Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Chaves, Rodrigo S
AU  - Chaves RS
AD  - Department of Genetics and Evolutionary Biology, Institute for Biosciences, 
      University of Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Silva, Carolliny M
AU  - Silva CM
AD  - Department of Genetics and Evolutionary Biology, Institute for Biosciences, 
      University of Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Chaves, Juliana C S
AU  - Chaves JCS
AD  - Department of Genetics and Evolutionary Biology, Institute for Biosciences, 
      University of Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Melo, Karla P
AU  - Melo KP
AD  - Department of Genetics and Evolutionary Biology, Institute for Biosciences, 
      University of Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Ferrari, Merari F R
AU  - Ferrari MFR
AD  - Department of Genetics and Evolutionary Biology, Institute for Biosciences, 
      University of Sao Paulo, Sao Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160830
PL  - England
TA  - IBRO Rep
JT  - IBRO reports
JID - 101691215
PMC - PMC6084862
OTO - NOTNLM
OT  - Aging
OT  - Early neurodegeneration
OT  - Hippocampus
OT  - Hyperphosphorylated Tau
OT  - Treadmill running
OT  - TrkB receptor
EDAT- 2016/08/30 00:00
MHDA- 2016/08/30 00:01
PMCR- 2016/08/30
CRDT- 2018/08/24 06:00
PHST- 2016/04/17 00:00 [received]
PHST- 2016/08/18 00:00 [revised]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2018/08/24 06:00 [entrez]
PHST- 2016/08/30 00:00 [pubmed]
PHST- 2016/08/30 00:01 [medline]
PHST- 2016/08/30 00:00 [pmc-release]
AID - S2451-8301(16)30003-6 [pii]
AID - 10.1016/j.ibror.2016.08.001 [doi]
PST - epublish
SO  - IBRO Rep. 2016 Aug 30;1:19-31. doi: 10.1016/j.ibror.2016.08.001. eCollection 2016 
      Dec.