PMID- 30136473
OWN - NLM
STAT- MEDLINE
DCOM- 20181017
LR  - 20191210
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 36
IP  - 6
DP  - 2018 Jun 8
TI  - [Determination of deltamethrin and its toxicity biomarkers in rabbit urine by 
      high performance liquid chromatography-tandem mass spectrometry].
PG  - 523-530
LID - 10.3724/SP.J.1123.2018.03002 [doi]
AB  - A method was developed for the determination of biomarkers related to toxicity of 
      deltamethrin in rabbit urine by high performance liquid chromatography-tandem 
      mass spectrometry (HPLC-MS/MS). The target analytes in this method are as 
      follows:deltamethrin and its two metabolites 
      (1R-cis)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane carboxylic acid 
      (dibromochrysanthemic acid) and 3-phenoxybenzoic acid (3-PBA), and five toxic 
      biomarkers, viz. serotonin hydrochloride (5-HT), 5-hydroxyindole-3-acetic acid 
      (5-HIAA), 3-nitropropionic acid (3-NPA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), 
      and 6-methoxyguanine. Urine samples were cleaned by matrix solid-phase dispersion 
      extraction (MSPD) with diatomite; and protein was precipitated with 
      trichloroacetic acid; and then the sample solutions were purified with 
      hydrophilic-lipophilic balance (HLB) solid-phase extraction cartridges. The 
      biomarkers were analyzed with electrospray ionization (ESI) in a positive and 
      negative switching scan mode, in which the positive scan mode was used for 
      deltamethrin, 5-HT, 5-HIAA, 8-OHdG, and 6-methoxyguanine, and the negative scan 
      mode was used for (1R-cis)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane, 
      3-PBA, and 3-NPA. The target compounds were quantified with the external standard 
      using matrix calibration curves. The linear regression curves of the eight target 
      compounds were linear with correlation coefficients no less than 0.9914. The LOD 
      and LOQ of 5-HIAA were 20 mug/L and 50 mug/L, respectively, and the LODs and LOQs 
      of the other analytes were 0.2-5.0 mug/L and 0.5-10 mug/L, respectively. The 
      average recoveries of the analytes spiked in rabbit urine ranged from 74.2% to 
      98.7% at three levels, with relative standard deviations (RSDs) no more than 12%. 
      The method was simple, fast, accurate, sensitive, and suitable for the detection 
      for the exposure evaluation of deltamethrin.
FAU - Cao, Wenqing
AU  - Cao W
AD  - Technical Center of Inspection and Quarantine, Shandong Entry-Exit Inspection and 
      Quarantine Bureau, Qingdao 266002, China.
AD  - College of Chemistry and Chemical Engineering of Ocean University of China, 
      Qingdao 266100, China.
FAU - Wu, Zhenxing
AU  - Wu Z
AD  - Technical Center of Inspection and Quarantine, Shandong Entry-Exit Inspection and 
      Quarantine Bureau, Qingdao 266002, China.
FAU - Liang, Chengzhu
AU  - Liang C
AD  - Technical Center of Inspection and Quarantine, Shandong Entry-Exit Inspection and 
      Quarantine Bureau, Qingdao 266002, China.
FAU - Jing, Ping
AU  - Jing P
AD  - Technical Center of Inspection and Quarantine, Shandong Entry-Exit Inspection and 
      Quarantine Bureau, Qingdao 266002, China.
FAU - Cui, Shuhua
AU  - Cui S
AD  - Technical Center of Inspection and Quarantine, Shandong Entry-Exit Inspection and 
      Quarantine Bureau, Qingdao 266002, China.
FAU - Yang, Guipeng
AU  - Yang G
AD  - College of Chemistry and Chemical Engineering of Ocean University of China, 
      Qingdao 266100, China.
FAU - Lin, Liming
AU  - Lin L
AD  - Technical Center of Inspection and Quarantine, Shandong Entry-Exit Inspection and 
      Quarantine Bureau, Qingdao 266002, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Biomarkers)
RN  - 0 (Nitriles)
RN  - 0 (Nitro Compounds)
RN  - 0 (Propionates)
RN  - 0 (Pyrethrins)
RN  - 2JTS8R821G (decamethrin)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - G9481N71RO (Deoxyguanosine)
RN  - QY4L0FOX0D (3-nitropropionic acid)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Animals
MH  - Biomarkers/urine
MH  - Chromatography, High Pressure Liquid
MH  - Deoxyguanosine/analogs & derivatives/urine
MH  - Limit of Detection
MH  - Nitriles/*toxicity/*urine
MH  - Nitro Compounds/urine
MH  - Propionates/urine
MH  - Pyrethrins/*toxicity/*urine
MH  - Rabbits
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - (1R-cis)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane carboxylic acid 
      (dibromochrysanthemic acid)
OT  - 3-phenoxybenzoic acid
OT  - biomarkers
OT  - deltamethrin
OT  - high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
EDAT- 2018/08/24 06:00
MHDA- 2018/10/18 06:00
CRDT- 2018/08/24 06:00
PHST- 2018/08/24 06:00 [entrez]
PHST- 2018/08/24 06:00 [pubmed]
PHST- 2018/10/18 06:00 [medline]
AID - 10.3724/SP.J.1123.2018.03002 [doi]
PST - ppublish
SO  - Se Pu. 2018 Jun 8;36(6):523-530. doi: 10.3724/SP.J.1123.2018.03002.