PMID- 30136491
OWN - NLM
STAT- MEDLINE
DCOM- 20181017
LR  - 20181017
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 36
IP  - 5
DP  - 2018 May 8
TI  - [Simultaneous determination of 12 monohydroxylated polycyclic aromatic 
      hydrocarbon metabolites in human urine by ultra-performance liquid chromatography 
      coupled with triple quadrupole mass spectrometry].
PG  - 487-492
LID - 10.3724/SP.J.1123.2017.12029 [doi]
AB  - An efficient and accurate method was developed for the simultaneous determination 
      of 12 monohydroxylated polycyclic aromatic hydrocarbon metabolites in human 
      urine. A 10.0-mL urine sample was hydrolyzed by enzyme and extracted using solid 
      phase extraction. The metabolites were separated on an Acquity UPLC((R))HSS T3 
      column (100 mmx2.1 mm, 1.8 mum) with a mobile phase comprising methanol and water. 
      The analytes were detected by electrospray ionization (ESI)-MS/MS in negative 
      mode and multiple reaction monitoring (MRM) mode. The linear ranges of the 12 
      metabolites were 0.04-20.0 mug/L with correlation coefficients above 0.99. The 
      detection limits were in the range of 0.01-0.41 mug/L and the recoveries were 
      80.0%-105%. The intra-group relative standard deviations (RSDs) were less than 
      9.12% and the inter-group RSDs were less than 19.7%. This method was applied to 
      the analysis of 100 urine samples and the results showed that the method was 
      simple, sensitive and selective.
FAU - Fu, Hui
AU  - Fu H
AD  - National Institute of Environmental Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100021, China.
FAU - Hu, Xiaojian
AU  - Hu X
AD  - National Institute of Environmental Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100021, China.
FAU - Chen, Xi
AU  - Chen X
AD  - National Institute of Environmental Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100021, China.
FAU - Lin, Shaobin
AU  - Lin S
AD  - National Institute of Environmental Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100021, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
SB  - IM
MH  - *Chromatography, High Pressure Liquid
MH  - Humans
MH  - Limit of Detection
MH  - Polycyclic Aromatic Hydrocarbons/*urine
MH  - Solid Phase Extraction
MH  - *Tandem Mass Spectrometry
OTO - NOTNLM
OT  - monohydroxylated metabolites of polycyclic aromatic hydrocarbons
OT  - solid phase extraction (SPE)
OT  - ultra-performance liquid chromatography-triple quadrupole mass spectrometry 
      (UPLC-MS/MS)
OT  - urine
EDAT- 2018/08/24 06:00
MHDA- 2018/10/18 06:00
CRDT- 2018/08/24 06:00
PHST- 2018/08/24 06:00 [entrez]
PHST- 2018/08/24 06:00 [pubmed]
PHST- 2018/10/18 06:00 [medline]
AID - 10.3724/SP.J.1123.2017.12029 [doi]
PST - ppublish
SO  - Se Pu. 2018 May 8;36(5):487-492. doi: 10.3724/SP.J.1123.2017.12029.