PMID- 30136518
OWN - NLM
STAT- MEDLINE
DCOM- 20181017
LR  - 20181017
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 36
IP  - 4
DP  - 2018 Apr 8
TI  - [Determination of 42 glucocorticoids in infant eczema products by auto-solid 
      phase extraction-ultra high performance liquid chromatography-tandem mass 
      spectrometry].
PG  - 356-361
LID - 10.3724/SP.J.1123.2017.10035 [doi]
AB  - A method was developed for the determination of 42 glucocorticoids in infant 
      eczema products by auto-solid phase extraction-high performance liquid 
      chromatography-tandem mass spectrometry (ASPE-UHPLC-MS/MS).The analytes were 
      extracted by acetonitrile after dispersing in saturated sodium chloride 
      solution.Macromolecules matrix were precipitated by adding potassium and zinc 
      acetate, and then purified by HLB SPE column.The chromatographic separations were 
      performed on a DIKMA Endeavorsil(TM) C18 column (100 mmx2.1 mm, 1.7 
      mum).Acetonitrile and 0.1%(v/v) formic acid aqueous solution were used as the 
      mobile phases.Electrospray ionization (ESI) source was operated in the positive 
      mode using multiple reaction monitoring (MRM) scanning mode.The results were 
      quantified by external standard method.The correlation coefficients of linear 
      calibration curves were greater than 0.998 in the corresponding mass 
      concentration ranges.The average recoveries at three spiked levels ranged from 
      78.7% to 101.5%, and the relative standard deviations (RSDs) were 
      2.0%-8.8%(n=6).The LODs (S/N >/= 3) and LOQs were 0.002-0.031 mg/kg and 
      0.0007-0.103 mg/kg, respectively.The method is simple, rapid, sensitive, and 
      reliable, and can be used for the detection of glucocorticoids in infant eczema 
      products.
FAU - Pan, Xiaohong
AU  - Pan X
AD  - Hunan Institute for Food and Drug Control, Changsha 410001, China. ##Email#.
FAU - Yin, Shuai
AU  - Yin S
AD  - Hunan Institute for Food and Drug Control, Changsha 410001, China. ##Email#.
FAU - Liu, Yuling
AU  - Liu Y
AD  - Hunan Institute for Food and Drug Control, Changsha 410001, China. ##Email#.
FAU - Long, Lingyun
AU  - Long L
AD  - Hunan Institute for Food and Drug Control, Changsha 410001, China. ##Email#.
FAU - Zhao, Wei
AU  - Zhao W
AD  - Hunan Institute for Food and Drug Control, Changsha 410001, China. ##Email#.
FAU - Meng, Qingyu
AU  - Meng Q
AD  - Hunan Institute for Food and Drug Control, Changsha 410001, China. ##Email#.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Eczema/drug therapy
MH  - Glucocorticoids/*analysis
MH  - Limit of Detection
MH  - Skin Cream/*analysis
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - auto-solid phase extraction (ASPE)
OT  - glucocorticoid
OT  - infant eczema products
OT  - ultra high performance liquid chromatography-tandem mass spectrometry 
      (UHPLC-MS-MS)
EDAT- 2018/08/24 06:00
MHDA- 2018/10/18 06:00
CRDT- 2018/08/24 06:00
PHST- 2018/08/24 06:00 [entrez]
PHST- 2018/08/24 06:00 [pubmed]
PHST- 2018/10/18 06:00 [medline]
AID - 10.3724/SP.J.1123.2017.10035 [doi]
PST - ppublish
SO  - Se Pu. 2018 Apr 8;36(4):356-361. doi: 10.3724/SP.J.1123.2017.10035.