PMID- 30136536
OWN - NLM
STAT- MEDLINE
DCOM- 20181018
LR  - 20181018
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 36
IP  - 7
DP  - 2018 Jul 8
TI  - [Rapid determination of 66 antibiotics in cosmetics using ultra high performance 
      liquid chromatography-linear ion trap/Orbitrap mass spectrometry].
PG  - 643-650
LID - 10.3724/SP.J.1123.2018.01041 [doi]
AB  - A rapid screening and determination method, in conjunction with a database for 
      confirmation, was established based on 66 antibiotic compounds using ultra-high 
      performance liquid chromatography-linear ion trap/Orbitrap high resolution mass 
      spectrometry (UPLC-LTQ/Orbitrap MS). The analytes were extracted with 
      acetonitrile using ultrasonic extraction. The separation was performed on a C18 
      column (100 mmx2.1 mm, 1.8 mum) with a gradient elution of 0.1% (v/v) formic acid 
      and acetonitrile. The retention time and accurate mass of the precursor ion were 
      used for rapid screening in positive ionization mode, with the fragment ions 
      obtained by higher energy collisional dissociation used for confirmation. The 
      results indicated that each compound showed good linearity with a correlation 
      coefficient of R(2)>0.99. The limits of detection (LODs) were in the range 2-4 
      mug/kg, and the limits of quantification (LOQs) were in the range 5-10 mug/kg. The 
      average recoveries at three levels (1LOQ, 10LOQ, and 30LOQ) were between 58.2% 
      and 119.1%, and the relative standard deviations (RSDs) were between 1.03% and 
      11.9%. The method is simple, rapid, reliable, and accurate, which is suitable for 
      rapid screening and determination of the 66 antibiotic compounds in cosmetics.
FAU - Li, Hongying
AU  - Li H
AD  - Hubei Institute for Drug Control, Wuhan 430075, China.
FAU - Shen, Huadan
AU  - Shen H
AD  - School of Pharmaceutical Science, Hubei University of Chinese Medicine, Wuhan 
      430065, China.
FAU - Fang, Jiangji
AU  - Fang J
AD  - School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of 
      Technology, Wuhan 430070, China.
FAU - Zhang, Jingya
AU  - Zhang J
AD  - Hubei Institute for Drug Control, Wuhan 430075, China.
FAU - Ding, Xiaoping
AU  - Ding X
AD  - Hubei Institute for Drug Control, Wuhan 430075, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cosmetics)
SB  - IM
MH  - Anti-Bacterial Agents/*analysis
MH  - *Chromatography, High Pressure Liquid
MH  - Cosmetics/*analysis
MH  - Limit of Detection
MH  - *Mass Spectrometry
OTO - NOTNLM
OT  - antibiotics
OT  - cosmetics
OT  - linear ion trap/Orbitrap high resolution mass spectrometry(LTQ/Orbitrap MS)
OT  - ultra-high performance liquid chromatography(UPLC)
EDAT- 2018/08/24 06:00
MHDA- 2018/10/20 06:00
CRDT- 2018/08/24 06:00
PHST- 2018/08/24 06:00 [entrez]
PHST- 2018/08/24 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
AID - 10.3724/SP.J.1123.2018.01041 [doi]
PST - ppublish
SO  - Se Pu. 2018 Jul 8;36(7):643-650. doi: 10.3724/SP.J.1123.2018.01041.