PMID- 30138829 OWN - NLM STAT- MEDLINE DCOM- 20181114 LR - 20181114 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 242 IP - Pt B DP - 2018 Nov TI - Long-term exposure to fine particulate matter and tachycardia and heart rate: Results from 10 million reproductive-age adults in China. PG - 1371-1378 LID - S0269-7491(18)31611-7 [pii] LID - 10.1016/j.envpol.2018.08.022 [doi] AB - BACKGROUND: Epidemiological evidence of the association of long-term ambient fine particulate matter (aerodynamic diameter 80 beats per minute (bpm). The annual average ambient PM(2.5) concentrations were obtained from a hybrid satellite-based geophysical statistical model. Linear mixed models and mixed effects logistic regressions adjusted for potential confounding were performed to explore the associations of PM(2.5) with resting heart rate and PM(2.5) with tachycardia, respectively. The effect modifiers by sex, age, body mass index, urbanity, race, region, smoking status, and drinking status were also assessed. Attributable cases and population fraction were estimated according to the PM(2.5)- tachycardia relationship. RESULTS: The mean age was 28 years, and 16.3% of the participants had tachycardia. The odds ratio for tachycardia was 1.018 (95% confidence intervals [CI]: 1.017, 1.020) per 10 mug/m(3) increase in the 3-year average PM(2.5) exposure. A 10 mug/m(3) increase in the 3-year average ambient PM(2.5) level was associated with a 0.076 (95% CI: 0.073, 0.079) bpm elevation in the resting heart rate. Of the tachycardia burden, 4.0% (95% CI: 3.8%, 4.3%) could be attributed to ambient PM(2.5) exposure in Chinese reproductive-age adults. CONCLUSIONS: Exposures to ambient PM(2.5) were associated with elevated resting heart rate. It might be possible to decrease China's avoidable tachycardia burden in reproductive-age adults through decreasing PM(2.5) levels. CI - Copyright (c) 2018 Elsevier Ltd. All rights reserved. FAU - Xie, Xiaoxu AU - Xie X AD - National Research Institute for Health and Family Planning, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China. FAU - Wang, Yuanyuan AU - Wang Y AD - National Research Institute for Health and Family Planning, Beijing, China. FAU - Yang, Ying AU - Yang Y AD - National Research Institute for Health and Family Planning, Beijing, China. FAU - Xu, Jihong AU - Xu J AD - National Research Institute for Health and Family Planning, Beijing, China. FAU - Zhang, Ya AU - Zhang Y AD - National Research Institute for Health and Family Planning, Beijing, China. FAU - Tang, Wenbin AU - Tang W AD - National Research Institute for Health and Family Planning, Beijing, China. FAU - Guo, Tongjun AU - Guo T AD - National Research Institute for Health and Family Planning, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China. FAU - Wang, Qiaomei AU - Wang Q AD - Department of Maternal and Child Health, National Health and Family Planning Commission, Beijing, China. FAU - Shen, Haiping AU - Shen H AD - Department of Maternal and Child Health, National Health and Family Planning Commission, Beijing, China. FAU - Zhang, Yiping AU - Zhang Y AD - Department of Maternal and Child Health, National Health and Family Planning Commission, Beijing, China. FAU - Yan, Donghai AU - Yan D AD - Department of Maternal and Child Health, National Health and Family Planning Commission, Beijing, China. FAU - Peng, Zuoqi AU - Peng Z AD - National Research Institute for Health and Family Planning, Beijing, China. FAU - Chen, Yixin AU - Chen Y AD - National Research Institute for Health and Family Planning, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China; Department of Computer Science and Engineering, Washington University in St. Louis, MO, 63130, USA. FAU - He, Yuan AU - He Y AD - National Research Institute for Health and Family Planning, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China; Research Center for Population Health and Risk Assessment, National Human Genetic Resources Center, Beijing, China. Electronic address: heyuan8506@126.com. FAU - Ma, Xu AU - Ma X AD - National Research Institute for Health and Family Planning, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China; Research Center for Population Health and Risk Assessment, National Human Genetic Resources Center, Beijing, China. Electronic address: xmgenetic@126.com. LA - eng PT - Journal Article DEP - 20180811 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Air Pollutants) RN - 0 (Particulate Matter) SB - IM MH - Adult MH - Air Pollutants/analysis/*toxicity MH - Air Pollution/adverse effects/analysis MH - China/epidemiology MH - Cross-Sectional Studies MH - Female MH - Heart Rate/*drug effects MH - Humans MH - Logistic Models MH - Male MH - Middle Aged MH - Models, Statistical MH - Particle Size MH - Particulate Matter/analysis/*toxicity MH - Tachycardia/*chemically induced/epidemiology MH - Young Adult OTO - NOTNLM OT - Air pollution OT - China OT - Fine particulate matter OT - Heart rate OT - Tachycardia EDAT- 2018/08/24 06:00 MHDA- 2018/11/15 06:00 CRDT- 2018/08/24 06:00 PHST- 2018/04/10 00:00 [received] PHST- 2018/08/04 00:00 [revised] PHST- 2018/08/06 00:00 [accepted] PHST- 2018/08/24 06:00 [pubmed] PHST- 2018/11/15 06:00 [medline] PHST- 2018/08/24 06:00 [entrez] AID - S0269-7491(18)31611-7 [pii] AID - 10.1016/j.envpol.2018.08.022 [doi] PST - ppublish SO - Environ Pollut. 2018 Nov;242(Pt B):1371-1378. doi: 10.1016/j.envpol.2018.08.022. Epub 2018 Aug 11.