PMID- 30139626
OWN - NLM
STAT- MEDLINE
DCOM- 20190122
LR  - 20240331
IS  - 2352-3964 (Electronic)
IS  - 2352-3964 (Linking)
VI  - 35
DP  - 2018 Sep
TI  - The effects of human leukocyte antigen DRB1*13 and apolipoprotein E on 
      age-related variability of synchronous neural interactions in healthy women.
PG  - 288-294
LID - S2352-3964(18)30313-X [pii]
LID - 10.1016/j.ebiom.2018.08.026 [doi]
AB  - BACKGROUND: Age-related brain changes are well-documented and influenced by 
      genetics. Extensive research links apolipoprotein E (apoE) to brain function, 
      with the E4 allele serving as a risk factor for brain disease, including 
      Alzheimer's disease, and the E2 allele conferring protection. Recent evidence 
      also supports protective effects of another gene, human leukocyte antigen (HLA) 
      DRB1*13, on brain disease and age-related brain atrophy in cognitively healthy 
      adults. Here we investigated the effects of apoE and HLA DRB1*13 on brain 
      function by examining changes in neural network properties with age in healthy 
      adults. METHODS: One hundred seventy-eight cognitively healthy women (28-99 y 
      old) underwent a magnetoencephalography scan and provided a blood sample for 
      genetic analysis. Age-related changes in neural network variability in genetic 
      subgroups of DRB1*13 x apoE genotype combinations were assessed using linear 
      regression of network variability against age. FINDINGS: For individuals lacking 
      a DRB1*13 allele and/or carrying an apoE4 allele, network variability increased 
      significantly with age. In contrast, no such increase was observed in the 
      presence of DRB1*13 and/or apoE2. INTERPRETATION: These findings extend previous 
      research documenting the protective effect of DRB1*13 on brain structure to 
      include protection against age-related changes in brain function, and demonstrate 
      similar protective effects on neural network variability for either DRB1*13 or 
      apoE2. These protective effects could be due to reduction or elimination of 
      factors known to disrupt brain function, including neuroinflammation and amyloid 
      beta protein. FUNDING: U.S. Department of Veterans Affairs, and University of 
      Minnesota.
CI  - Published by Elsevier B.V.
FAU - James, Lisa M
AU  - James LM
AD  - Brain Sciences Center, Department of Veterans Affairs Health Care System, 
      Minneapolis, MN 5541, USA; Department of Neuroscience, University of Minnesota 
      Medical School, Minneapolis, MN 55455, USA; Department of Psychiatry, University 
      of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Cognitive 
      Sciences, University of Minnesota, Minneapolis, MN 55455, USA. Electronic 
      address: lmjames@umn.edu.
FAU - Dolan, Stacy
AU  - Dolan S
AD  - Brain Sciences Center, Department of Veterans Affairs Health Care System, 
      Minneapolis, MN 5541, USA.
FAU - Leuthold, Arthur C
AU  - Leuthold AC
AD  - Brain Sciences Center, Department of Veterans Affairs Health Care System, 
      Minneapolis, MN 5541, USA; Department of Neuroscience, University of Minnesota 
      Medical School, Minneapolis, MN 55455, USA.
FAU - Engdahl, Brian E
AU  - Engdahl BE
AD  - Brain Sciences Center, Department of Veterans Affairs Health Care System, 
      Minneapolis, MN 5541, USA; Department of Neuroscience, University of Minnesota 
      Medical School, Minneapolis, MN 55455, USA; Center for Cognitive Sciences, 
      University of Minnesota, Minneapolis, MN 55455, USA; Department of Psychology, 
      University of Minnesota, Minneapolis, MN 55455, USA.
FAU - Georgopoulos, Angeliki
AU  - Georgopoulos A
AD  - Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 
      55455, USA.
FAU - Georgopoulos, Apostolos P
AU  - Georgopoulos AP
AD  - Brain Sciences Center, Department of Veterans Affairs Health Care System, 
      Minneapolis, MN 5541, USA; Department of Neuroscience, University of Minnesota 
      Medical School, Minneapolis, MN 55455, USA; Department of Psychiatry, University 
      of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Cognitive 
      Sciences, University of Minnesota, Minneapolis, MN 55455, USA; Department of 
      Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
LA  - eng
PT  - Journal Article
DEP - 20180820
PL  - Netherlands
TA  - EBioMedicine
JT  - EBioMedicine
JID - 101647039
RN  - 0 (Apolipoproteins E)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Apolipoproteins E/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - HLA-DRB1 Chains/*metabolism
MH  - Humans
MH  - Middle Aged
MH  - Nerve Net/*metabolism
PMC - PMC6161538
OTO - NOTNLM
OT  - Apolipoprotein E
OT  - DRB1*13
OT  - Healthy brain aging
OT  - Human leukocyte antigen
OT  - Magnetoencephalography
OT  - Neural network
EDAT- 2018/08/25 06:00
MHDA- 2019/01/23 06:00
PMCR- 2018/08/20
CRDT- 2018/08/25 06:00
PHST- 2018/06/06 00:00 [received]
PHST- 2018/08/02 00:00 [revised]
PHST- 2018/08/10 00:00 [accepted]
PHST- 2018/08/25 06:00 [pubmed]
PHST- 2019/01/23 06:00 [medline]
PHST- 2018/08/25 06:00 [entrez]
PHST- 2018/08/20 00:00 [pmc-release]
AID - S2352-3964(18)30313-X [pii]
AID - 10.1016/j.ebiom.2018.08.026 [doi]
PST - ppublish
SO  - EBioMedicine. 2018 Sep;35:288-294. doi: 10.1016/j.ebiom.2018.08.026. Epub 2018 
      Aug 20.