PMID- 30140696
OWN - NLM
STAT- MEDLINE
DCOM- 20190107
LR  - 20190107
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2018
DP  - 2018
TI  - Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents.
PG  - 3984068
LID - 10.1155/2018/3984068 [doi]
LID - 3984068
AB  - The therapeutic potential of stigmasterol, a natural steroid alcohol with 
      established immune-modulatory properties, was assessed on allergic cutaneous 
      responses. We examined its suppressive effect on immunoglobulin E (IgE)-mediated 
      active cutaneous anaphylaxis (ACA), compound 48/80 (C48/80)-induced pruritus, and 
      irritant dermatitis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 
      Stigmasterol at 10-100 mg/kg significantly inhibited ACA with reduction in 
      reaction area and concentration of the extravasated Evans blue dye. Given at 50 
      and 100 mg/kg, stigmasterol significantly inhibited C48/80-induced scratching 
      behaviour when compared to saline-treated C48/80-injected control. Skin 
      histopathology of injected sites confirmed that stigmasterol reduced mast cell 
      trafficking and degranulation associated with C48/80-induced pruritus. 
      Stigmasterol controlled inflammatory features such as ear skin oedema and 
      neutrophilia and also reduced serum levels of TNFalpha induced by topical application 
      of TPA. Epidermal layer thickening and inflammatory cell infiltration of ear skin 
      tissue were significantly reduced by stigmasterol. Taken together, stigmasterol 
      demonstrates significant potential as a molecule of interest in allergic skin 
      disease therapy.
FAU - Antwi, Aaron O
AU  - Antwi AO
AUID- ORCID: 0000-0001-9713-9487
AD  - Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, 
      College of Health Sciences, Kwame Nkrumah University of Science & Technology 
      (KNUST), Kumasi, Ghana.
FAU - Obiri, David D
AU  - Obiri DD
AUID- ORCID: 0000-0001-7906-9534
AD  - Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, 
      College of Health Sciences, Kwame Nkrumah University of Science & Technology 
      (KNUST), Kumasi, Ghana.
FAU - Osafo, Newman
AU  - Osafo N
AUID- ORCID: 0000-0001-8142-2368
AD  - Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, 
      College of Health Sciences, Kwame Nkrumah University of Science & Technology 
      (KNUST), Kumasi, Ghana.
FAU - Essel, Leslie B
AU  - Essel LB
AD  - Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, 
      College of Health Sciences, Kwame Nkrumah University of Science & Technology 
      (KNUST), Kumasi, Ghana.
FAU - Forkuo, Arnold D
AU  - Forkuo AD
AD  - Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, 
      College of Health Sciences, Kwame Nkrumah University of Science & Technology 
      (KNUST), Kumasi, Ghana.
FAU - Atobiga, Clement
AU  - Atobiga C
AD  - Department of Pathology, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.
LA  - eng
PT  - Journal Article
DEP - 20180724
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 99WUK5D0Y8 (Stigmasterol)
SB  - IM
MH  - Animals
MH  - Drug Eruptions/drug therapy
MH  - Ghana
MH  - Hypersensitivity/*drug therapy
MH  - Mast Cells
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Rats
MH  - Rats, Wistar
MH  - Rodentia
MH  - Skin/drug effects/*immunology
MH  - Stigmasterol/*pharmacology
PMC - PMC6081592
EDAT- 2018/08/25 06:00
MHDA- 2019/01/08 06:00
PMCR- 2018/07/24
CRDT- 2018/08/25 06:00
PHST- 2018/02/28 00:00 [received]
PHST- 2018/05/14 00:00 [revised]
PHST- 2018/06/25 00:00 [accepted]
PHST- 2018/08/25 06:00 [entrez]
PHST- 2018/08/25 06:00 [pubmed]
PHST- 2019/01/08 06:00 [medline]
PHST- 2018/07/24 00:00 [pmc-release]
AID - 10.1155/2018/3984068 [doi]
PST - epublish
SO  - Biomed Res Int. 2018 Jul 24;2018:3984068. doi: 10.1155/2018/3984068. eCollection 
      2018.