PMID- 30142554
OWN - NLM
STAT- MEDLINE
DCOM- 20190305
LR  - 20190305
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 268
DP  - 2018 Oct
TI  - Altered levels of brain-derived neurotrophic factor, proBDNF and tissue 
      plasminogen activator in children with posttraumatic stress disorder.
PG  - 478-483
LID - S0165-1781(18)30077-5 [pii]
LID - 10.1016/j.psychres.2018.07.013 [doi]
AB  - The current study aims to compare the serum brain-derived neurotrophic factor 
      (BDNF), proBDNF and tissue plasminogen activator (tPA) levels in cases that have 
      developed posttraumatic stress disorder (PTSD) in consequence of sexual abuse 
      with those in healthy control subjects. Thirty-one female patients between 8 and 
      18 years of age who have been diagnosed with PTSD due to sexual abuse and 
      thirty-one healthy female volunteer controls were included in the study. 
      Frequency, intensity and severity of PTSD symptoms were assessed on the basis of 
      Clinician-Administered Post-Traumatic Stress Disorder Scale for Children and 
      Adolescents (CAPS-CA). Serum BDNF, proBDNF and tPA levels were measured by 
      Enzyme-Linked Immunosorbent Assay (ELISA) method. Results of the present study 
      revealed that serum levels of BDNF and proBDNF in PTSD group were significantly 
      lower but tPA level was significantly higher as compared to healthy control 
      subjects. There were no correlations between CAPS-CA scores and BDNF, proBDNF and 
      tPA levels. Decreased levels of BDNF, as suggested to have a role in the 
      etiopathogenesis of PTSD, appear to be a result of the reduction in proBDNF 
      production. The increased tPA levels in such cases, on the other hand, can be a 
      compensatory mechanism serving to increase the BDNF levels.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Aksu, Sehra
AU  - Aksu S
AD  - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale 
      University, Denizli, Turkey.
FAU - Unlu, Gulsen
AU  - Unlu G
AD  - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale 
      University, Denizli, Turkey. Electronic address: gulsenu@pau.edu.tr.
FAU - Kardesler, Aysen Cetin
AU  - Kardesler AC
AD  - Department of Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, 
      Turkey.
FAU - Cakaloz, Burcu
AU  - Cakaloz B
AD  - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale 
      University, Denizli, Turkey.
FAU - Aybek, Hulya
AU  - Aybek H
AD  - Department of Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, 
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180726
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 3.4.21.68 (PLAT protein, human)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Adolescent
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Child
MH  - Child Abuse, Sexual/*psychology
MH  - Female
MH  - Humans
MH  - Stress Disorders, Post-Traumatic/*blood/psychology
MH  - Tissue Plasminogen Activator/*blood
EDAT- 2018/08/25 06:00
MHDA- 2019/03/06 06:00
CRDT- 2018/08/25 06:00
PHST- 2018/01/13 00:00 [received]
PHST- 2018/06/05 00:00 [revised]
PHST- 2018/07/06 00:00 [accepted]
PHST- 2018/08/25 06:00 [pubmed]
PHST- 2019/03/06 06:00 [medline]
PHST- 2018/08/25 06:00 [entrez]
AID - S0165-1781(18)30077-5 [pii]
AID - 10.1016/j.psychres.2018.07.013 [doi]
PST - ppublish
SO  - Psychiatry Res. 2018 Oct;268:478-483. doi: 10.1016/j.psychres.2018.07.013. Epub 
      2018 Jul 26.