PMID- 30142753
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 34
DP  - 2018 Aug
TI  - Pain during the acute phase of Guillain-Barre syndrome.
PG  - e11595
LID - 10.1097/MD.0000000000011595 [doi]
LID - e11595
AB  - In this study, we tried to describe the characteristics of pain and explore the 
      association between the incidence of pain and abnormal laboratory test results in 
      patients during the acute phase of Guillain-Barre syndrome (GBS).This 
      retrospective cohort study enrolled 252 patients with GBS who were in the acute 
      phase of the disease. We collected data regarding the location and type of pain, 
      the onset time, clinical variables and laboratory tests, including the levels of 
      uric acid (UA), albumin, cerebrospinal fluid protein (CSFP), cerebrospinal fluid 
      glucose (CSFG), fasting glucose upon admission, and blood creatinine. The pain 
      descriptors were compared to the severity of disease and laboratory examination 
      results.Around 34.5% of the patients reported pain during the acute phase of GBS. 
      Pain was negatively correlated with the disease severity during the acute phase. 
      In total, 29 of the 87 (33.3%) patients reported pain during the 2 weeks 
      preceding the onset of weakness. The concentration of CSFP was positively 
      associated with the incidence of pain, while the concentrations of UA and albumin 
      were not correlated with the incidence of pain.We found that 33.3% of the GBS 
      patients experienced pain within 2 weeks of onset, and the pain was positively 
      associated with CSFP concentration but was not correlated with disease severity.
FAU - Yao, Shaoli
AU  - Yao S
AD  - Department of Neurology, West China Hospital, Sichuan University Department of 
      Internal Medicine, Hospital of Chengdu Office of People's Govermment of Tibetan 
      Autonomous Region Department of Neurology, West China Hospital, Sichuan 
      University, China.
FAU - Chen, Hongxi
AU  - Chen H
FAU - Zhang, Qin
AU  - Zhang Q
FAU - Shi, Ziyan
AU  - Shi Z
FAU - Liu, Ju
AU  - Liu J
FAU - Lian, Zhiyun
AU  - Lian Z
FAU - Feng, Huiru
AU  - Feng H
FAU - Du, Qin
AU  - Du Q
FAU - Xie, Jinlu
AU  - Xie J
FAU - Ge, Weihong
AU  - Ge W
FAU - Zhou, Hongyu
AU  - Zhou H
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (Cerebrospinal Fluid Proteins)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Cerebrospinal Fluid Proteins/metabolism
MH  - Female
MH  - Guillain-Barre Syndrome/*complications/metabolism
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Pain/*epidemiology
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC6113041
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/08/26 06:00
MHDA- 2018/09/05 06:00
PMCR- 2018/08/24
CRDT- 2018/08/26 06:00
PHST- 2018/08/26 06:00 [entrez]
PHST- 2018/08/26 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2018/08/24 00:00 [pmc-release]
AID - 00005792-201808240-00005 [pii]
AID - MD-D-17-07808 [pii]
AID - 10.1097/MD.0000000000011595 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Aug;97(34):e11595. doi: 10.1097/MD.0000000000011595.