PMID- 30143224
OWN - NLM
STAT- MEDLINE
DCOM- 20181029
LR  - 20191210
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 1032
DP  - 2018 Nov 22
TI  - Rapid and on-site analysis of amphetamine-type illicit drugs in whole blood and 
      raw urine by slug-flow microextraction coupled with paper spray mass 
      spectrometry.
PG  - 75-82
LID - S0003-2670(18)30748-7 [pii]
LID - 10.1016/j.aca.2018.06.006 [doi]
AB  - In this study, a slug-flow microextraction (SFME) coupled with paper spray mass 
      spectrometry (PS-MS) method was developed for rapid and on-site analysis of trace 
      amphetamine-type illicit drugs including amphetamine (AM), methamphetamine (MA) 
      and 3,4-methylenedioxy-N-methylamphetamine (MDMA) in complex biological samples 
      such as whole blood and raw urine. The method involved the application of SFME 
      for rapid extraction of trace amphetamine-type illicit drugs from whole blood and 
      raw urine samples, followed by PS for direct MS analysis under ambient and 
      open-air conditions. The experimental parameters including extraction solvent, 
      extraction cycle, high voltage, and spray solvent, etc., were all investigated, 
      and the optimized conditions showed an enhanced sensitivity of 1-2 order of 
      magnitudes compared with PS-MS. The method showed good linearity, with 
      correlation coefficient values (r) of no less than 0.9979 for analysis of AM, MA, 
      and MDMA in human whole blood and raw urine without additional sample 
      pretreatments. The limits of detection and quantification were 0.01-0.05 ng/mL 
      and 0.05-0.2 ng/mL, respectively. Satisfactory recoveries were also obtained, 
      with 74.2-94.9% for whole blood and 80.2-103.6% for raw urine, respectively. All 
      of our experimental results demonstrated that SFME-PS-MS showed great potential 
      for rapid, on-site, in situ, and high-throughput screening of amphetamine-type 
      illicit drugs in various biological samples.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Yang, Yunyun
AU  - Yang Y
AD  - Guangdong Engineering and Technology Research Center for Ambient Mass 
      Spectrometry, Guangdong Provincial Key Laboratory of Emergency Test for Dangerous 
      Chemicals, Guangdong Institute of Analysis (China National Analytical Center 
      Guangzhou), 100 Xianlie Middle Road, Guangzhou, 510070, China. Electronic 
      address: yy_yang@vip.126.com.
FAU - Wu, Junhui
AU  - Wu J
AD  - State Key Laboratory of Biocontrol, South China Sea Bio-Resource Exploitation and 
      Utilization Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen 
      University, 135 Xingangxi Road, Guangzhou, 510275, China.
FAU - Deng, Jiewei
AU  - Deng J
AD  - State Key Laboratory of Biocontrol, South China Sea Bio-Resource Exploitation and 
      Utilization Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen 
      University, 135 Xingangxi Road, Guangzhou, 510275, China. Electronic address: 
      jwdeng@126.com.
FAU - Yuan, Ke
AU  - Yuan K
AD  - Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, 
      School of Marine Sciences, Sun Yat-Sen University, 135 Xingangxi Road, Guangzhou, 
      510275, China.
FAU - Chen, Xi
AU  - Chen X
AD  - Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, 
      School of Marine Sciences, Sun Yat-Sen University, 135 Xingangxi Road, Guangzhou, 
      510275, China.
FAU - Liu, Ning
AU  - Liu N
AD  - Guangdong Engineering and Technology Research Center for Ambient Mass 
      Spectrometry, Guangdong Provincial Key Laboratory of Emergency Test for Dangerous 
      Chemicals, Guangdong Institute of Analysis (China National Analytical Center 
      Guangzhou), 100 Xianlie Middle Road, Guangzhou, 510070, China.
FAU - Wang, Xiaowei
AU  - Wang X
AD  - Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, 
      School of Marine Sciences, Sun Yat-Sen University, 135 Xingangxi Road, Guangzhou, 
      510275, China.
FAU - Luan, Tiangang
AU  - Luan T
AD  - State Key Laboratory of Biocontrol, South China Sea Bio-Resource Exploitation and 
      Utilization Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen 
      University, 135 Xingangxi Road, Guangzhou, 510275, China. Electronic address: 
      cesltg@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180605
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Illicit Drugs)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*analysis
MH  - Humans
MH  - Illicit Drugs/*analysis
MH  - *Liquid Phase Microextraction
MH  - Mass Spectrometry
MH  - *Paper
MH  - *Substance Abuse Detection
OTO - NOTNLM
OT  - Amphetamine-type illicit drugs
OT  - Paper spray-mass spectrometry
OT  - Raw urine
OT  - Slug-flow microextraction
OT  - Whole blood
EDAT- 2018/08/26 06:00
MHDA- 2018/10/30 06:00
CRDT- 2018/08/26 06:00
PHST- 2018/04/07 00:00 [received]
PHST- 2018/06/01 00:00 [revised]
PHST- 2018/06/02 00:00 [accepted]
PHST- 2018/08/26 06:00 [entrez]
PHST- 2018/08/26 06:00 [pubmed]
PHST- 2018/10/30 06:00 [medline]
AID - S0003-2670(18)30748-7 [pii]
AID - 10.1016/j.aca.2018.06.006 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2018 Nov 22;1032:75-82. doi: 10.1016/j.aca.2018.06.006. Epub 2018 
      Jun 5.