PMID- 30143695
OWN - NLM
STAT- MEDLINE
DCOM- 20191030
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Aug 24
TI  - Associations between Variants in BDNF/BDNFOS Gene and Lumbar Disc Herniation Risk 
      among Han Chinese People.
PG  - 12782
LID - 10.1038/s41598-018-31146-6 [doi]
LID - 12782
AB  - Lumbar disc herniation (LDH) is a low back pain disorder and associated with 
      several single nucleotide polymorphisms (SNPs). However, the role of 
      brain-derived neurotrophic factor (BDNF) and BDNFOS gene in LDH susceptibility 
      remains unknown. To examine whether the variants contribute to LDH, 7 SNPs were 
      genotyped in 380 patients and 692 healthy controls among Han Chinese population. 
      Multiple genetic models, stratification by age/gender and haploview analysis was 
      used by calculating odds ratio (OR) and 95% confidence intervals (CIs). 
      Rs11030064 in BDNFOS gene was associated with modified susceptibility for LDH at 
      age </=50 years but three loci (rs6265, rs11030104 and rs10767664) of BDNF gene 
      increased LDH risk at age >50 years. Further, rs11030096 polymorphism in BDNFOS 
      gene was associated with LDH the increased susceptibility of LDH in females. 
      Haplotype analysis shown that haplotype "GCC" in the block (rs988712, rs7481311, 
      and rs11030064) increased LDH risk (OR = 1.49, 95% CI = 1.06-2.10, p = 0.022) at 
      age </=50 years. However, there was no significant association between BDNF/BDNFOS 
      gene and LDH risk in the overall before stratified analysis. For the first time, 
      our results provide evidence on polymorphism of BDNF / BDNFOS gene associated 
      with LDH risk in Chinese Han population.
FAU - Zhu, Yong
AU  - Zhu Y
AD  - The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 
      010030, China.
FAU - Jia, Haiyu
AU  - Jia H
AD  - The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, 
      China.
FAU - Li, Jiabin
AU  - Li J
AD  - Inner Mongolia Medical University, Hohhot, 010050, China.
FAU - Ren, Shaodong
AU  - Ren S
AD  - Inner Mongolia Medical University, Hohhot, 010050, China.
FAU - Huang, Zhi
AU  - Huang Z
AD  - The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 
      010030, China.
FAU - Li, Feng
AU  - Li F
AD  - The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 
      010030, China.
FAU - Xing, Wenhua
AU  - Xing W
AD  - The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 
      010030, China.
FAU - Li, Shunan
AU  - Li S
AD  - The Hohhot First Hospital, Hohhot, 010020, China. 522641997@qq.com.
FAU - Yang, Xuejun
AU  - Yang X
AD  - The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 
      010030, China. Yangxuejun2004@126.com.
LA  - eng
PT  - Journal Article
DEP - 20180824
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Asian People/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Humans
MH  - Intervertebral Disc Displacement/*genetics
MH  - Lumbar Vertebrae/*pathology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Assessment
MH  - Risk Factors
PMC - PMC6109184
COIS- The authors declare no competing interests.
EDAT- 2018/08/26 06:00
MHDA- 2019/10/31 06:00
PMCR- 2018/08/24
CRDT- 2018/08/26 06:00
PHST- 2018/03/12 00:00 [received]
PHST- 2018/08/07 00:00 [accepted]
PHST- 2018/08/26 06:00 [entrez]
PHST- 2018/08/26 06:00 [pubmed]
PHST- 2019/10/31 06:00 [medline]
PHST- 2018/08/24 00:00 [pmc-release]
AID - 10.1038/s41598-018-31146-6 [pii]
AID - 31146 [pii]
AID - 10.1038/s41598-018-31146-6 [doi]
PST - epublish
SO  - Sci Rep. 2018 Aug 24;8(1):12782. doi: 10.1038/s41598-018-31146-6.