PMID- 30144395
OWN - NLM
STAT- MEDLINE
DCOM- 20190313
LR  - 20190313
IS  - 1365-2710 (Electronic)
IS  - 0269-4727 (Linking)
VI  - 44
IP  - 1
DP  - 2019 Feb
TI  - Discovery of "folded DNA" structures in human cells: Potential drug targets.
PG  - 125-128
LID - 10.1111/jcpt.12758 [doi]
AB  - WHAT IS KNOWN AND OBJECTIVE: The double-helical conformation of human DNA (hDNA) 
      is so axiomatic that it is called the "canonical" form. Recently, though, 
      intrastrand folds ("I-motifs" and "G-quadruplexes") have been identified in hDNA. 
      These could be targets for novel drug discovery. COMMENT: Any interruption of the 
      canonical form of hDNA fundamentally impacts the normal progression of 
      transduction and translation. In particular, the synthesis of receptors and 
      cognate protein ligands would be affected, as well as their affinity for-and 
      signal transduction of-pharmacotherapeutic agents. Recent studies have identified 
      normally occurring, folded structures superimposed on the usual double-helix 
      motif of hDNA. WHAT IS NEW AND CONCLUSION: The newly identified "folded DNA" 
      structures ("I-motifs" and "G-quadruplexes") could represent novel drug-discovery 
      targets, most likely for cancer.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Raffa, Robert B
AU  - Raffa RB
AUID- ORCID: 0000-0002-1456-4451
AD  - University of Arizona College of Pharmacy, Tucson, Arizona.
AD  - Temple University School of Pharmacy, Philadelphia, Pennsylvania.
AD  - Neumentum, Inc., Palo Alto, California.
FAU - Pergolizzi, Joseph V Jr
AU  - Pergolizzi JV Jr
AD  - Neumentum, Inc., Palo Alto, California.
AD  - NEMA Research, Inc., Naples, Florida.
FAU - Taylor, Robert Jr
AU  - Taylor R Jr
AD  - NEMA Research, Inc., Naples, Florida.
FAU - Ossipov, Michael H
AU  - Ossipov MH
AD  - University of Arizona College of Medicine, Tucson, Arizona.
CN  - NEMA Research Group
LA  - eng
PT  - Journal Article
DEP - 20180825
PL  - England
TA  - J Clin Pharm Ther
JT  - Journal of clinical pharmacy and therapeutics
JID - 8704308
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Ligands)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - DNA/*chemistry
MH  - Drug Discovery/*methods
MH  - G-Quadruplexes
MH  - Humans
MH  - Ligands
MH  - Neoplasms/drug therapy/genetics
OTO - NOTNLM
OT  - G-quadruplex
OT  - I-motif
OT  - cancer
OT  - drug target
OT  - folded DNA
EDAT- 2018/08/26 06:00
MHDA- 2019/03/14 06:00
CRDT- 2018/08/26 06:00
PHST- 2018/06/06 00:00 [received]
PHST- 2018/08/01 00:00 [accepted]
PHST- 2018/08/26 06:00 [pubmed]
PHST- 2019/03/14 06:00 [medline]
PHST- 2018/08/26 06:00 [entrez]
AID - 10.1111/jcpt.12758 [doi]
PST - ppublish
SO  - J Clin Pharm Ther. 2019 Feb;44(1):125-128. doi: 10.1111/jcpt.12758. Epub 2018 Aug 
      25.