PMID- 30144780
OWN - NLM
STAT- MEDLINE
DCOM- 20190508
LR  - 20211204
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Print)
IS  - 0306-4530 (Linking)
VI  - 98
DP  - 2018 Dec
TI  - Discrimination exposure and DNA methylation of stress-related genes in Latina 
      mothers.
PG  - 131-138
LID - S0306-4530(18)30386-X [pii]
LID - 10.1016/j.psyneuen.2018.08.014 [doi]
AB  - Latina mothers, who have the highest fertility rate among all ethnic groups in 
      the US, are often exposed to discrimination. The epigenetic changes related to 
      this discrimination are largely unknown. This study is the first to explore the 
      relationship between discrimination and DNA methylation of stress regulatory 
      genes in Latinas. Our sample was Latina women (n = 147) with a mean age of 27.6 
      years who were assessed at 24-32 weeks' gestation (T1) and 4-6 weeks postpartum 
      (T2) and reside in the U.S. Blood was collected at T1, and the Everyday 
      Discrimination Scale (EDS) was administered at T1 and T2. DNA Methylation at 
      candidate gene regions was determined by bisulphite pyrosequencing. Associations 
      between EDS and DNA methylation were assessed via zero-inflated Poisson models, 
      adjusting for covariates and multiple-test comparisons. Discrimination was 
      negatively associated with methylation at CpG sites within the glucocorticoid 
      receptor (NR3C1) and brain-derived neurotrophic factor (BDNF) genes that were 
      consistent over time. In addition, discrimination was negatively associated with 
      methylation of a CpG in the glucocorticoid binding protein (FKBP5) at T1 but not 
      at T2. This study underscores associations between discrimination and epigenetic 
      markers of DNA methylation in Latinas that warrant further investigation to 
      better understand the biological pathways and psychopathological effects of 
      discrimination on Latina mothers and their families.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Santos, Hudson P Jr
AU  - Santos HP Jr
AD  - School of Nursing, University of North Carolina at Chapel Hill, North Carolina, 
      United States. Electronic address: hsantos@unc.edu.
FAU - Nephew, Benjamin C
AU  - Nephew BC
AD  - Department of Biology and Biotechnology, Worcester Polytechnic Institute, 
      Worcester, MA, United States.
FAU - Bhattacharya, Arjun
AU  - Bhattacharya A
AD  - Department of Biostatistics, Gillings School of Global Public Health, University 
      of North Carolina at Chapel Hill, North Carolina, United States.
FAU - Tan, Xianming
AU  - Tan X
AD  - Department of Biostatistics, Gillings School of Global Public Health, University 
      of North Carolina at Chapel Hill, North Carolina, United States.
FAU - Smith, Laura
AU  - Smith L
AD  - School of Healthcare Science, Manchester Metropolitan University, Manchester, 
      United Kingdom.
FAU - Alyamani, Reema Abdulrahman S
AU  - Alyamani RAS
AD  - School of Healthcare Science, Manchester Metropolitan University, Manchester, 
      United Kingdom.
FAU - Martin, Elizabeth M
AU  - Martin EM
AD  - Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental 
      Health Sciences, Research Triangle Park, North Carolina, United States.
FAU - Perreira, Krista
AU  - Perreira K
AD  - Department of Social Medicine, School of Medicine, University of North Carolina 
      at Chapel Hill, North Carolina, United States.
FAU - Fry, Rebecca C
AU  - Fry RC
AD  - Department of Environmental Sciences and Engineering, Curriculum in Toxicology, 
      Gillings School of Global Public Health, University of North Carolina at Chapel 
      Hill, North Carolina, United States.
FAU - Murgatroyd, Christopher
AU  - Murgatroyd C
AD  - School of Healthcare Science, Manchester Metropolitan University, Manchester, 
      United Kingdom.
LA  - eng
GR  - P2C HD050924/HD/NICHD NIH HHS/United States
GR  - TL1 TR001110/TR/NCATS NIH HHS/United States
GR  - UL1 TR001111/TR/NCATS NIH HHS/United States
GR  - UL1 TR002489/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180816
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NR3C1 protein, human)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 5.2.1.- (Tacrolimus Binding Proteins)
RN  - EC 5.2.1.8 (tacrolimus binding protein 5)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - CpG Islands/genetics
MH  - DNA Methylation/genetics
MH  - Epigenesis, Genetic/genetics
MH  - Female
MH  - Hispanic or Latino/*genetics/psychology
MH  - Humans
MH  - Hydrocortisone
MH  - Mothers
MH  - Neuronal Plasticity
MH  - Pregnancy
MH  - Promoter Regions, Genetic/genetics
MH  - Receptors, Glucocorticoid/genetics/metabolism
MH  - Social Discrimination/*psychology
MH  - Stress, Psychological/*genetics/metabolism
MH  - Tacrolimus Binding Proteins/genetics/metabolism
PMC - PMC6204298
MID - NIHMS1504922
OTO - NOTNLM
OT  - DNA methylation
OT  - Discrimination
OT  - Epigenetics
OT  - Hispanic/Latina
OT  - Stress
OT  - Women's health
COIS- Conflict of interest: None.
EDAT- 2018/08/26 06:00
MHDA- 2019/05/09 06:00
PMCR- 2019/12/01
CRDT- 2018/08/26 06:00
PHST- 2018/04/20 00:00 [received]
PHST- 2018/08/08 00:00 [revised]
PHST- 2018/08/08 00:00 [accepted]
PHST- 2018/08/26 06:00 [pubmed]
PHST- 2019/05/09 06:00 [medline]
PHST- 2018/08/26 06:00 [entrez]
PHST- 2019/12/01 00:00 [pmc-release]
AID - S0306-4530(18)30386-X [pii]
AID - 10.1016/j.psyneuen.2018.08.014 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2018 Dec;98:131-138. doi: 
      10.1016/j.psyneuen.2018.08.014. Epub 2018 Aug 16.