PMID- 30144948
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20220408
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 223
IP  - 12
DP  - 2018 Dec
TI  - Assessment of circulating FCepsilonRIa in Chronic Spontaneous Urticaria patients and 
      its correlation with clinical and immunological variables.
PG  - 807-811
LID - S0171-2985(18)30094-9 [pii]
LID - 10.1016/j.imbio.2018.08.009 [doi]
AB  - Chronic spontaneous urticaria (CSU) is a chronic type characterized by episodes 
      of wheals with or without angioedema. Autoantibody against the alpha subunit of 
      Fc epsilon receptor (FcepsilonRIa) was detected in CSU patients' sera. The study aims 
      to evaluate the clinical utility of skin tests in CSU patients. In addition, it 
      assesses the presence of circulating FcepsilonRIa in CSU patients and their correlation 
      with other clinical and immunological variables. The study includes 40 healthy 
      controls and 40 CSU patients who had urticaria symptoms for at least 8 weeks. All 
      subjects underwent the following tests: autologous serum skin test (ASST), 
      autologous plasma skin test (APST), immunoglobulin E (IgE), antinuclear 
      antibodies (ANA), antithyroid antibodies (ATA). An in-house enzyme-linked 
      immunosorbent assay was used for FcepsilonRIa detection. The prevalence of ANA and ATA 
      in CSU was 7.5% and 20% respectively. Total IgE was significantly higher in CSU 
      than in controls (p < 0.0001). The study detected circulating antibody to FcepsilonRIalpha 
      in 2.5% of controls and 52.5% of CSU patients (p < 0.0001). The prevalence of 
      antibody to FcepsilonRIa was 27.3% and 83.3% of ASST negative and positive patients 
      respectively (p = 0.0004). But the prevalence was 17.6% and 78.3% of APST 
      negative and positive patients respectively (p = 0.0002). In conclusion, 
      Circulating antibody to FcepsilonRIa has a role in the pathogenic mechanisms of CSU.
CI  - Copyright (c) 2018 Elsevier GmbH. All rights reserved.
FAU - Baioumy, Shereen A
AU  - Baioumy SA
AD  - Department of Microbiology and Immunology, Faculty of Human Medicine, Zagazig 
      University, Egypt.
FAU - Esawy, Marwa M
AU  - Esawy MM
AD  - Department of Clinical Pathology, Faculty of Human Medicine, Zagazig University, 
      Egypt. Electronic address: MMAtya@medicine.zu.edu.eg.
FAU - Shabana, Marwa A
AU  - Shabana MA
AD  - Department of Clinical Pathology, Faculty of Human Medicine, Zagazig University, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20180820
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (FcepsilonRI alpha-chain, human)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, IgE)
SB  - IM
MH  - Adult
MH  - Autoantibodies/blood/pharmacology
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - *Immunity
MH  - Immunoglobulin G/blood/pharmacology
MH  - Male
MH  - Middle Aged
MH  - Receptors, IgE/*blood
MH  - Urticaria/*blood/diagnosis/*immunology
OTO - NOTNLM
OT  - APST
OT  - ASST
OT  - Autoantibody
OT  - Fc receptor
OT  - Urticaria
EDAT- 2018/08/27 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/08/27 06:00
PHST- 2018/05/16 00:00 [received]
PHST- 2018/08/14 00:00 [revised]
PHST- 2018/08/19 00:00 [accepted]
PHST- 2018/08/27 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/08/27 06:00 [entrez]
AID - S0171-2985(18)30094-9 [pii]
AID - 10.1016/j.imbio.2018.08.009 [doi]
PST - ppublish
SO  - Immunobiology. 2018 Dec;223(12):807-811. doi: 10.1016/j.imbio.2018.08.009. Epub 
      2018 Aug 20.