PMID- 30145331
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20181102
IS  - 1873-6971 (Electronic)
IS  - 0367-326X (Linking)
VI  - 130
DP  - 2018 Oct
TI  - Hydroquinone and terpene glucosides from Leontopodium leontopodioides and their 
      lipase inhibitory activity.
PG  - 89-93
LID - S0367-326X(18)31152-3 [pii]
LID - 10.1016/j.fitote.2018.08.010 [doi]
AB  - Three new glucosides of hydroquinone, monoterpene, and megastigmane, benzyl 
      2,5-dihydroxybenzoate 5-O-beta-d-glucopyranoside (isotrichocarpin, 1), 
      (2S,3R)-3,7-dimethyl-6-octene-1,2,3-triol 2-O-beta-d-glucopyranoside 
      (leontopodioside D, 4), and 
      (6R,7R,8R,9S)-6,9-epoxy-7,8-dihydroxymegastigman-4-en-3-one 
      8-O-beta-d-glucopyranoside (leontopodioside E, 7) were isolated from the whole herbs 
      of Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae), along with 
      nebrodenside A (2), pungenin (3), betulalbuside A (5), geranyl 
      O-beta-d-glucopyranoside (6), and 3beta-hydroxy-beta-ionone 3-O-beta-d-glucopyranoside (8). 
      Their structure were determined by spectroscopic and chemical methods. All the 
      known compounds were reported from this species for the first time. Compounds 2-6 
      showed potent in vitro pancreatic lipase inhibitory activity, suggesting their 
      participation in the reductive effect of the herbs on triglyceride absorption.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Gou, Ping
AU  - Gou P
AD  - College of Life Science and Technology, Xinjiang University, Urumqi 830046, 
      China. Electronic address: gou_ping@sina.com.
FAU - Xiao, Yangyang
AU  - Xiao Y
AD  - Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic 
      Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China 
      Botanical Garden, Chinese Academy of Sciences, Guangzhou, China; University of 
      Chinese Academy of Sciences, Beijing 100049, China.
FAU - Lv, Ling
AU  - Lv L
AD  - Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic 
      Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China 
      Botanical Garden, Chinese Academy of Sciences, Guangzhou, China; University of 
      Chinese Academy of Sciences, Beijing 100049, China.
FAU - Xie, Haihui
AU  - Xie H
AD  - Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic 
      Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China 
      Botanical Garden, Chinese Academy of Sciences, Guangzhou, China; University of 
      Chinese Academy of Sciences, Beijing 100049, China. Electronic address: 
      xiehaih@scbg.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20180823
PL  - Netherlands
TA  - Fitoterapia
JT  - Fitoterapia
JID - 16930290R
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Glucosides)
RN  - 0 (Hydroquinones)
RN  - 0 (Phytochemicals)
RN  - 0 (Terpenes)
RN  - EC 3.1.1.3 (Lipase)
SB  - IM
MH  - Asteraceae/*chemistry
MH  - China
MH  - Enzyme Inhibitors/isolation & purification
MH  - Glucosides/*isolation & purification
MH  - Hydroquinones/*isolation & purification
MH  - Lipase/*antagonists & inhibitors
MH  - Molecular Structure
MH  - Phytochemicals/isolation & purification
MH  - Terpenes/*isolation & purification
OTO - NOTNLM
OT  - Hydroquinone glucoside
OT  - Leontopodium leontopodioides
OT  - Megastigmane glucoside
OT  - Monoterpene glucoside
OT  - Pancreatic lipase inhibition
EDAT- 2018/08/27 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/08/27 06:00
PHST- 2018/07/15 00:00 [received]
PHST- 2018/08/18 00:00 [revised]
PHST- 2018/08/22 00:00 [accepted]
PHST- 2018/08/27 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/08/27 06:00 [entrez]
AID - S0367-326X(18)31152-3 [pii]
AID - 10.1016/j.fitote.2018.08.010 [doi]
PST - ppublish
SO  - Fitoterapia. 2018 Oct;130:89-93. doi: 10.1016/j.fitote.2018.08.010. Epub 2018 Aug 
      23.