PMID- 30148360 OWN - NLM STAT- MEDLINE DCOM- 20181015 LR - 20181015 IS - 1520-5118 (Electronic) IS - 0021-8561 (Linking) VI - 66 IP - 37 DP - 2018 Sep 19 TI - Determination of Nine Bisphenol-Diglycidyl Ethers in Human Breast Milk by Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry. PG - 9810-9818 LID - 10.1021/acs.jafc.8b03088 [doi] AB - Because of their widespread use, and the mutagenicity and teratogenicity observed in in vitro studies, bisphenol-diglycidyl ethers (BDGEs) were suspected of posing health risks to humans, especially to infants. Quantifying exposure of BDGEs from breast milk is essential in assessing the potential health risks of these ubiquitous compounds to infants. However, there is no reported analytical method for the determination of BDGEs in breast milk. In this context, we developed a rapid and sensitive method based on ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to measure nine BDGEs in breast milk. The analytes were extracted with acetonitrile and fat was removed by freezing under -20 degrees C. The extracts were further purified by PRiME HLB solid-phase extraction (SPE) cartridge. The limits of detection (LODs) and quantification (LOQs) for the analytes were 0.033-0.500 and 0.100-1.500 mug L(-1), respectively. The recoveries of BDGEs were ranged from 71.33% to 114.33%. Good method reproducibility regarding intra- and interday precision was observed, yielding relative standard deviations (RSDs) less than 11.81% and 10.83%, respectively. The proposed method was successfully applied to 20 breast milk samples. BADGE.2H(2)O, BADGE.HCl.H(2)O, BADGE.H(2)O, BADGE.HCl, BFDGE.2H(2)O, and BFDGE.2HCl were detected. BFDGE.2HCl was the dominant BDGE with detection rate of 65.0% and the concentration ranging from 0.4 to 1.0 mug L(-1). This is the first report describing the occurrence of BDGEs in breast milk. FAU - Yang, Runhui AU - Yang R AD - College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin 300457 , China. AD - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning , Beijing Center for Disease Prevention and Control , Beijing 100013 , China. FAU - Niu, Yumin AU - Niu Y AD - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning , Beijing Center for Disease Prevention and Control , Beijing 100013 , China. FAU - Wang, Bin AU - Wang B AD - College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin 300457 , China. FAU - Zhang, Jing AU - Zhang J AD - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning , Beijing Center for Disease Prevention and Control , Beijing 100013 , China. FAU - Shao, Bing AU - Shao B AUID- ORCID: 0000-0001-5631-6889 AD - College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin 300457 , China. AD - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning , Beijing Center for Disease Prevention and Control , Beijing 100013 , China. AD - Beijing Advanced Innovation Center for Food Nutrition and Human Health , China Agricultural University , Beijing 100193 , China. LA - eng PT - Journal Article DEP - 20180907 PL - United States TA - J Agric Food Chem JT - Journal of agricultural and food chemistry JID - 0374755 RN - 0 (Benzhydryl Compounds) RN - 0 (Epoxy Compounds) RN - F3XRM1NX4H (2,2-bis(4-glycidyloxyphenyl)propane) SB - IM MH - Benzhydryl Compounds/*chemistry MH - China MH - Chromatography, High Pressure Liquid/*methods MH - Epoxy Compounds/*chemistry MH - Female MH - Food Contamination/analysis MH - Humans MH - Milk, Human/*chemistry MH - Tandem Mass Spectrometry/*methods OTO - NOTNLM OT - UPLC-MS/MS OT - bisphenol-diglycidyl ether OT - breast milk OT - solid phase extraction EDAT- 2018/08/28 06:00 MHDA- 2018/10/16 06:00 CRDT- 2018/08/28 06:00 PHST- 2018/08/28 06:00 [pubmed] PHST- 2018/10/16 06:00 [medline] PHST- 2018/08/28 06:00 [entrez] AID - 10.1021/acs.jafc.8b03088 [doi] PST - ppublish SO - J Agric Food Chem. 2018 Sep 19;66(37):9810-9818. doi: 10.1021/acs.jafc.8b03088. Epub 2018 Sep 7.