PMID- 30148393
OWN - NLM
STAT- MEDLINE
DCOM- 20181113
LR  - 20181113
IS  - 1939-0599 (Electronic)
IS  - 0012-1649 (Linking)
VI  - 54
IP  - 9
DP  - 2018 Sep
TI  - Unraveling current and future adolescent depressive symptoms: The role of stress 
      reactivity across physiological systems.
PG  - 1650-1660
LID - 10.1037/dev0000530 [doi]
AB  - Neurobiological processes are highlighted in animal and theoretical models of the 
      development of depression, but there is mixed empirical evidence about 
      associations between stress physiology and depressive symptoms. Adolescence has 
      been highlighted as a period during which coordination across physiological 
      stress response systems may be particularly important. However, most studies have 
      focused on depressive symptoms and physiological reactivity in isolated systems. 
      The goal of this study was to examine associations of 
      hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS; 
      i.e., sympathetic and parasympathetic nervous system [SNS and PNS, respectively]) 
      reactivity with depressive systems, as well as the interrelatedness of reactivity 
      across systems. Participants were adolescents (n = 153, 10-17 years) from diverse 
      backgrounds, recruited from the community. Adolescents experienced a stressor, 
      during which cortisol (HPA axis), skin conductance level (SCL; SNS), and 
      respiratory sinus arrhythmia (RSA; PNS) were measured; youth also reported 
      depressive symptoms. Some youth (n = 60) reported depressive symptoms again 1 
      year later as part of another study. Results from latent growth analysis embedded 
      in a structural equation model (SEM) indicated that concurrent depressive 
      symptoms were predicted by an interaction between cortisol reactivity and 
      baseline RSA levels, with fewer symptoms for adolescents who had lower baseline 
      RSA and greater cortisol reactivity. Controlling for concurrent depressive 
      symptoms, prolonged cortisol recovery (above and beyond cortisol or ANS 
      reactivity), was related to prospective depressive symptoms. Results support and 
      extend theoretical arguments about the role of dysregulated stress physiology in 
      the development of depressive symptoms, and the importance of multisystem 
      approaches to understanding the role of stress physiology in risk and resilience. 
      (PsycINFO Database Record
CI  - (c) 2018 APA, all rights reserved).
FAU - Lucas-Thompson, Rachel G
AU  - Lucas-Thompson RG
AUID- ORCID: 0000-0001-7558-2285
AD  - Department of Human Development and Family Studies, Colorado State University.
FAU - McKernan, Charlotte J
AU  - McKernan CJ
AD  - Department of Human Development and Family Studies, Colorado State University.
FAU - Henry, Kimberly L
AU  - Henry KL
AD  - Department of Psychology, Colorado State University.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dev Psychol
JT  - Developmental psychology
JID - 0260564
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Depression/diagnosis/*physiopathology
MH  - Disease Progression
MH  - Female
MH  - Galvanic Skin Response
MH  - Humans
MH  - Hydrocortisone/metabolism
MH  - Male
MH  - Prognosis
MH  - Respiratory Sinus Arrhythmia
MH  - Stress, Psychological/diagnosis/*physiopathology
EDAT- 2018/08/28 06:00
MHDA- 2018/11/14 06:00
CRDT- 2018/08/28 06:00
PHST- 2018/08/28 06:00 [entrez]
PHST- 2018/08/28 06:00 [pubmed]
PHST- 2018/11/14 06:00 [medline]
AID - 2018-41343-005 [pii]
AID - 10.1037/dev0000530 [doi]
PST - ppublish
SO  - Dev Psychol. 2018 Sep;54(9):1650-1660. doi: 10.1037/dev0000530.