PMID- 30148412
OWN - NLM
STAT- MEDLINE
DCOM- 20190913
LR  - 20200309
IS  - 1555-8592 (Electronic)
IS  - 1547-6278 (Print)
IS  - 1547-6278 (Linking)
VI  - 14
IP  - 3
DP  - 2018
TI  - Application of drug delivery systems for the controlled delivery of growth 
      factors to treat nervous system injury.
PG  - 123-128
LID - 10.1080/15476278.2018.1491183 [doi]
AB  - Nervous system injury represent the most common injury and was unique clinical 
      challenge. Using of growth factors (GFs) for the treatment of nervous system 
      injury showed effectiveness in halting its process. However, simple application 
      of GFs could not achieve high efficacy because of its rapid diffusion into body 
      fluids and lost from the lesion site. The drug delivery systems (DDSs) 
      construction used to deliver GFs were investigated so that they could surmount 
      its rapid diffusion and retain at the injury site. This study summarizes commonly 
      used DDSs for sustained release of GFs that provide neuroprotection or 
      restoration effects for nervous system injury.
FAU - Ma, Fukai
AU  - Ma F
AUID- ORCID: 0000-0003-0997-2626
AD  - a Department of Neurosurgery , Fudan University Huashan Hospital and National Key 
      Laboratory of Medical Neurobiology, the Institutes of Brain Science, Shanghai 
      Medical College, Fudan University , Shanghai , China.
FAU - Wang, Fan
AU  - Wang F
AD  - a Department of Neurosurgery , Fudan University Huashan Hospital and National Key 
      Laboratory of Medical Neurobiology, the Institutes of Brain Science, Shanghai 
      Medical College, Fudan University , Shanghai , China.
AD  - b Department of Neurology , Guizhou Provincial People's Hospital , Guiyang , 
      China.
FAU - Li, Ronggang
AU  - Li R
AD  - a Department of Neurosurgery , Fudan University Huashan Hospital and National Key 
      Laboratory of Medical Neurobiology, the Institutes of Brain Science, Shanghai 
      Medical College, Fudan University , Shanghai , China.
AD  - c Department of Neurosurgery , Shanghai Public Health Clinical Center, Fudan 
      University , Shanghai , China.
FAU - Zhu, Jianhong
AU  - Zhu J
AD  - a Department of Neurosurgery , Fudan University Huashan Hospital and National Key 
      Laboratory of Medical Neurobiology, the Institutes of Brain Science, Shanghai 
      Medical College, Fudan University , Shanghai , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180827
PL  - United States
TA  - Organogenesis
JT  - Organogenesis
JID - 101253266
RN  - 0 (Biocompatible Materials)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Immobilized Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials
MH  - Delayed-Action Preparations/administration & dosage/therapeutic use
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Immobilized Proteins/administration & dosage/therapeutic use
MH  - Intercellular Signaling Peptides and Proteins/*administration & 
      dosage/*therapeutic use
MH  - Trauma, Nervous System/*drug therapy
PMC - PMC6300096
OTO - NOTNLM
OT  - drug delivery systems
OT  - growth factors
OT  - nervous system injury
OT  - neurogenesis
EDAT- 2018/08/28 06:00
MHDA- 2019/09/14 06:00
PMCR- 2019/08/27
CRDT- 2018/08/28 06:00
PHST- 2018/08/28 06:00 [pubmed]
PHST- 2019/09/14 06:00 [medline]
PHST- 2018/08/28 06:00 [entrez]
PHST- 2019/08/27 00:00 [pmc-release]
AID - 1491183 [pii]
AID - 10.1080/15476278.2018.1491183 [doi]
PST - ppublish
SO  - Organogenesis. 2018;14(3):123-128. doi: 10.1080/15476278.2018.1491183. Epub 2018 
      Aug 27.