PMID- 30149240
OWN - NLM
STAT- MEDLINE
DCOM- 20200121
LR  - 20200121
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 57
DP  - 2019 Jan
TI  - Nutritional status and cytokine concentration during chemotherapy in Mexican 
      children: A longitudinal analysis.
PG  - 46-51
LID - S0899-9007(18)30601-4 [pii]
LID - 10.1016/j.nut.2018.05.032 [doi]
AB  - OBJECTIVE: The aim of this study was to assess whether the nutritional status of 
      children with cancer is influenced by variations in cytokine concentrations 
      observed during chemotherapy. We also evaluated whether this relationship could 
      be modified by nutritional status at diagnosis and type of cancer. METHODS: 
      Mexican children with lymphoma or solid tumors were evaluated at diagnosis and at 
      2- and 6-mo follow-up visits. Blood samples were obtained to determine serum 
      prealbumin, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, leptin 
      concentrations, and hemoglobin. Children were classified as undernourished (UN) 
      or well nourished (WN), according to prealbumin concentration. The influence of 
      each cytokine on prealbumin concentration was analyzed by time-series regression 
      model. RESULTS: Fifty patients (ages 2-17 y) were enrolled. There were 17 
      children with lymphomas and 33 with solid tumors. At baseline, 56% were UN and 
      26% presented anemia; the frequencies of UN children were higher for those with 
      lymphoma than for those with a solid tumor (P = 0.003). By nutritional status, UN 
      children presented lower leptin (P = 0.002) but higher IL-6 concentrations 
      (P = 0.009) than the WN group. Children with lymphoma presented lower prealbumin 
      (P = 0.003), but higher TNF-alpha (P = 0.001) and IL-6 (P = 0.011) concentrations 
      than those with solid tumors. At follow-up, the concentration of prealbumin 
      increased and IL-6 decreased in children with lymphoma. Multivariate analysis 
      demonstrated that decreases in prealbumin concentration at the end of follow-up 
      were associated with increases in IL-6 and TNF-alpha concentration during 
      chemotherapy. CONCLUSIONS: These results suggest that the cytokine responses 
      during chemotherapy are related to nutritional status at the end of 6 mo of 
      treatment regardless of the initial nutritional status and the type of cancer.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Barbosa-Cortes, Lourdes
AU  - Barbosa-Cortes L
AD  - Medical Unit of Nutrition Research, Pediatric Hospital, Mexican Institute of 
      Social Security, Mexico City, Mexico. Electronic address: bcmariade@hotmail.com.
FAU - Klunder-Klunder, Miguel
AU  - Klunder-Klunder M
AD  - Department of Community Health Research, Federico Gomez Children's, Mexico 
      Secretary of Health, Mexico City, Mexico.
FAU - Lopez-Alarcon, Mardia
AU  - Lopez-Alarcon M
AD  - Medical Unit of Nutrition Research, Pediatric Hospital, Mexican Institute of 
      Social Security, Mexico City, Mexico.
FAU - Marquez, Hugo Rivera-
AU  - Marquez HR
AD  - Department of Hemato-Oncology, General Hospital of Mexico, Mexican Secretary of 
      Health, Mexico City, Mexico.
FAU - Lopez-Aguilar, Enrique
AU  - Lopez-Aguilar E
AD  - Department of Oncology, Pediatric Hospital, Mexican Institute of Social Security, 
      Mexico City, Mexico.
FAU - Tapia-Marcial, Andrea
AU  - Tapia-Marcial A
AD  - Clinical Laboratory, Pediatric Hospital, Mexican Institute of Social Security, 
      Mexico City, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180711
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Cytokines)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child Nutrition Disorders/*blood/*complications
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Mexico
MH  - Neoplasms/*blood/complications/*drug therapy
MH  - *Nutritional Status
OTO - NOTNLM
OT  - Cytokines
OT  - IL-6
OT  - Lymphomas
OT  - Solid tumors
OT  - TNF-alpha
OT  - Undernutrition
EDAT- 2018/08/28 06:00
MHDA- 2020/01/22 06:00
CRDT- 2018/08/28 06:00
PHST- 2017/11/10 00:00 [received]
PHST- 2018/05/07 00:00 [revised]
PHST- 2018/05/13 00:00 [accepted]
PHST- 2018/08/28 06:00 [pubmed]
PHST- 2020/01/22 06:00 [medline]
PHST- 2018/08/28 06:00 [entrez]
AID - S0899-9007(18)30601-4 [pii]
AID - 10.1016/j.nut.2018.05.032 [doi]
PST - ppublish
SO  - Nutrition. 2019 Jan;57:46-51. doi: 10.1016/j.nut.2018.05.032. Epub 2018 Jul 11.