PMID- 30149456
OWN - NLM
STAT- MEDLINE
DCOM- 20190826
LR  - 20200623
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 65
IP  - 4
DP  - 2018
TI  - The Influence of the Val66Met Polymorphism of Brain-Derived Neurotrophic Factor 
      on Neurological Function after Traumatic Brain Injury.
PG  - 1055-1064
LID - 10.3233/JAD-180585 [doi]
AB  - Functional outcomes after traumatic brain injury (TBI) vary widely across 
      patients with apparently similar injuries. This variability hinders prognosis, 
      therapy, and clinical innovation. Recently, single nucleotide polymorphism (SNPs) 
      that influence outcome after TBI have been identified. These discoveries create 
      opportunities to personalize therapy and stratify clinical trials. Both of these 
      changes would propel clinical innovation in the field. This review focuses on one 
      of most well-characterized of these SNPs, the Val66Met SNP in the brain-derived 
      neurotrophic factor (BDNF) gene. This SNP influences neurological function in 
      healthy subjects as well as TBI patients and patients with similar acute insults 
      to the central nervous system. A host of other patient-specific factors including 
      ethnicity, age, gender, injury severity, and post-injury time point modulate this 
      influence. These interactions confound efforts to define a simple relationship 
      between this SNP and TBI outcomes. The opportunities and challenges associated 
      with personalizing TBI therapy around this SNP and other similar SNPs are 
      discussed in light of these results.
FAU - Finan, John D
AU  - Finan JD
AD  - Department of Neurosurgery, NorthShore University Health System, Evanston, IL, 
      USA.
FAU - Udani, Shreya V
AU  - Udani SV
AD  - Department of Neurosurgery, NorthShore University Health System, Evanston, IL, 
      USA.
FAU - Patel, Vimal
AU  - Patel V
AD  - Department of Neurosurgery, NorthShore University Health System, Evanston, IL, 
      USA.
FAU - Bailes, Julian E
AU  - Bailes JE
AD  - Department of Neurosurgery, NorthShore University Health System, Evanston, IL, 
      USA.
LA  - eng
GR  - R21 NS098129/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
MH  - Brain Injuries, Traumatic/*complications/therapy
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Humans
MH  - Nervous System Diseases/*etiology/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Precision Medicine/methods
PMC - PMC6348870
MID - NIHMS992408
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - precision medicine
OT  - single nucleotide polymorphism
OT  - traumatic brain injury
EDAT- 2018/08/29 06:00
MHDA- 2019/08/27 06:00
PMCR- 2019/01/28
CRDT- 2018/08/29 06:00
PHST- 2018/08/29 06:00 [pubmed]
PHST- 2019/08/27 06:00 [medline]
PHST- 2018/08/29 06:00 [entrez]
PHST- 2019/01/28 00:00 [pmc-release]
AID - JAD180585 [pii]
AID - 10.3233/JAD-180585 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2018;65(4):1055-1064. doi: 10.3233/JAD-180585.