PMID- 30149746 OWN - NLM STAT- MEDLINE DCOM- 20191209 LR - 20191217 IS - 1793-6462 (Electronic) IS - 0129-0657 (Linking) VI - 29 IP - 5 DP - 2019 Jun TI - Aberrant Prefrontal-Thalamic-Cerebellar Circuit in Schizophrenia and Depression: Evidence From a Possible Causal Connectivity. PG - 1850032 LID - 10.1142/S0129065718500326 [doi] AB - Neuroimaging studies have suggested the presence of abnormalities in the prefrontal-thalamic-cerebellar circuit in schizophrenia (SCH) and depression (DEP). However, the common and distinct structural and causal connectivity abnormalities in this circuit between the two disorders are still unclear. In the current study, structural and resting-state functional magnetic resonance imaging (fMRI) data were acquired from 20 patients with SCH, 20 depressive patients and 20 healthy controls (HC). Voxel-based morphometry analysis was first used to assess gray matter volume (GMV). Granger causality analysis, seeded at regions with altered GMVs, was subsequently conducted. To discover the differences between the groups, ANCOVA and post hoc tests were performed. Then, the relationships between the structural changes, causal connectivity and clinical variables were investigated. Finally, a leave-one-out resampling method was implemented to test the consistency. Statistical analyses showed the GMV and causal connectivity changes in the prefrontal-thalamic-cerebellar circuit. Compared with HC, both SCH and DEP exhibited decreased GMV in middle frontal gyrus (MFG), and a lower GMV in MFG and medial prefrontal cortex (MPFC) in SCH than DEP. Compared with HC, both patient groups showed increased causal flow from the right cerebellum to the MPFC (common causal connectivity abnormalities). And distinct causal connectivity abnormalities (increased causal connectivity from the left thalamus to the MPFC in SCH than HC and DEP, and increased causal connectivity from the right cerebellum to the left thalamus in DEP than HC and SCH). In addition, the structural deficits in the MPFC and its causal connectivity from the cerebellum were associated with the negative symptom severity in SCH. This study found common/distinct structural deficits and aberrant causal connectivity patterns in the prefrontal-thalamic-cerebellar circuit in SCH and DEP, which may provide a potential direction for understanding the convergent and divergent psychiatric pathological mechanisms between SCH and DEP. Furthermore, concomitant structural and causal connectivity deficits in the MPFC may jointly contribute to the negative symptoms of SCH. FAU - Jiang, Yuchao AU - Jiang Y AD - * The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China. FAU - Duan, Mingjun AU - Duan M AD - * The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China. AD - dagger Department of psychiatry, Chengdu Mental Health Center, Chengdu, P. R. China. FAU - Chen, Xi AU - Chen X AD - * The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China. FAU - Zhang, Xingxing AU - Zhang X AD - * The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China. FAU - Gong, Jinnan AU - Gong J AD - * The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China. FAU - Dong, Debo AU - Dong D AD - * The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China. FAU - Li, Hui AU - Li H AD - * The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China. AD - dagger Department of psychiatry, Chengdu Mental Health Center, Chengdu, P. R. China. FAU - Yi, Qizhong AU - Yi Q AD - double dagger Psychological Medicine Center, The First Affiliated Hospital of Xinjiang, Medical University, Urumqi, P. R. China. FAU - Wang, Shuya AU - Wang S AD - section sign Biology Department, Emory University, Atlanta, GA, USA. FAU - Wang, Jijun AU - Wang J AD - paragraph sign Department of EEG Source Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China. FAU - Luo, Cheng AU - Luo C AD - * The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China. FAU - Yao, Dezhong AU - Yao D AD - * The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu P. R. China. LA - eng PT - Journal Article DEP - 20180716 PL - Singapore TA - Int J Neural Syst JT - International journal of neural systems JID - 9100527 SB - IM MH - Adolescent MH - Adult MH - Case-Control Studies MH - Cerebellum/*physiopathology MH - Depression/pathology/*physiopathology MH - Female MH - Gray Matter/pathology MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Neural Pathways/physiopathology MH - Neuroimaging MH - Prefrontal Cortex/pathology/*physiopathology MH - Schizophrenia/pathology/*physiopathology MH - Severity of Illness Index MH - Thalamus/*physiopathology MH - Young Adult OTO - NOTNLM OT - Schizophrenia OT - causal connectivity OT - depression OT - gray matter OT - resting-state fMRI EDAT- 2018/08/29 06:00 MHDA- 2019/12/18 06:00 CRDT- 2018/08/29 06:00 PHST- 2018/08/29 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2018/08/29 06:00 [entrez] AID - 10.1142/S0129065718500326 [doi] PST - ppublish SO - Int J Neural Syst. 2019 Jun;29(5):1850032. doi: 10.1142/S0129065718500326. Epub 2018 Jul 16.