PMID- 30150066
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 27
IP  - 11
DP  - 2018 Nov
TI  - Brain-Derived Neurotrophic Factor Levels are Lower in Chronic Stroke Patients: A 
      Relation with Manganese-dependent Superoxide Dismutase ALA16VAL Single Nucleotide 
      Polymorphism through Tumor Necrosis Factor-alpha and Caspases Pathways.
PG  - 3020-3029
LID - S1052-3057(18)30356-2 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2018.06.032 [doi]
AB  - The manganese-dependent superoxide dismutase (MnSOD) Ala16Val single nucleotide 
      polymorphism (SNP) has shown to be associated to risk factors of vascular 
      diseases. Brain-Derived Neurotrophic Factor (BDNF) plays an essential role in the 
      plasticity and neuronal regeneration of the brain after vascular injuries. 
      However, little is known about interaction between MnSOD Ala16Val SNP on stroke, 
      a frequent neurologic disease that involves various interacting pathways, such as 
      vascular dysfunctions, inflammation, and neurotrophic factors. In this sense, the 
      objective of this study was to investigate the relationship between MnSOD 
      Ala16Val SNP with BDNF levels on stroke and also its influence on nitrosative 
      stress, inflammatory, apoptotic, and DNA damage parameters. For this, 88 subjects 
      were investigated, 44 subjects poststroke and 44 healthy controls. Questionnaires 
      were applied to clinical characteristics and after laboratorial exams were 
      collected. We analyzed levels of oxidative/nitrosative stress, inflammatory, 
      apoptotic, and DNA damage markers. We showed a higher proportion of VV genotype 
      in poststroke as compared to healthy subjects. Nitrite/nitrate, Tumor Necrosis 
      Factor-alpha, Caspase 3 (CASP 3) and 8 (CASP 8) activation, Acethylcholinesterase 
      (AChE), and Picogreen levels were higher in VV poststroke group, as well as BDNF 
      and ACh levels were lower in VV and AV poststroke. We may suggest that V allele 
      carries a worse outcome profile after stroke, relating to nitrosative stress, 
      inflammatory, and apoptotic response. These events associated to a BDNF 
      reduction, probably, contribute to the appearance or reincidence of stroke.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Pascotini, Mr Eduardo Tanuri
AU  - Pascotini MET
AD  - Centro de Ciencias da Saude, Departamento de Neuropsiquiatria, Universidade 
      Federal de Santa Maria, RS; Centro de Ciencias Naturais e Exatas, Programa de 
      Pos-graduacao em Ciencias Biologicas: Bioquimica Toxicologica, Universidade 
      Federal de Santa Maria, RS.
FAU - Flores, Dr Ariane Ethur
AU  - Flores DAE
AD  - Centro de Ciencias da Saude, Departamento de Neuropsiquiatria, Universidade 
      Federal de Santa Maria, RS; Centro de Ciencias da Saude, Programa de 
      Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, RS.
FAU - Kegler, Mrs Aline
AU  - Kegler MA
AD  - Centro de Ciencias da Saude, Departamento de Neuropsiquiatria, Universidade 
      Federal de Santa Maria, RS; Centro de Ciencias Naturais e Exatas, Programa de 
      Pos-graduacao em Ciencias Biologicas: Bioquimica Toxicologica, Universidade 
      Federal de Santa Maria, RS.
FAU - Konzen, Mrs Vivana
AU  - Konzen MV
AD  - Centro de Ciencias da Saude, Departamento de Neuropsiquiatria, Universidade 
      Federal de Santa Maria, RS.
FAU - Fornari, Mrs Ana Leticia
AU  - Fornari MAL
AD  - Centro de Ciencias da Saude, Departamento de Neuropsiquiatria, Universidade 
      Federal de Santa Maria, RS.
FAU - Arend, Mrs Josi
AU  - Arend MJ
AD  - Centro de Ciencias da Saude, Departamento de Neuropsiquiatria, Universidade 
      Federal de Santa Maria, RS; Centro de Ciencias da Saude, Programa de 
      Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, RS.
FAU - Gabbi, Mrs Patricia
AU  - Gabbi MP
AD  - Centro de Ciencias da Saude, Programa de Pos-Graduacao em Farmacologia, 
      Universidade Federal de Santa Maria, RS.
FAU - Gobo, Mrs Luciana Assis
AU  - Gobo MLA
AD  - Centro de Ciencias da Saude, Departamento de Quimica, Universidade Federal de 
      Santa Maria, RS, Brazil.
FAU - Bochi, Dr Guilherme Vargas
AU  - Bochi DGV
AD  - Centro de Ciencias da Saude, Programa de Pos-Graduacao em Farmacologia, 
      Universidade Federal de Santa Maria, RS.
FAU - Prado, Dr Ana Lucia Cervi
AU  - Prado DALC
AD  - Servico de Fisioterapia, Hospital Universitario de Santa Maria, RS.
FAU - de Carvalho, Dr Leandro Machado
AU  - de Carvalho DLM
AD  - Centro de Ciencias da Saude, Departamento de Quimica, Universidade Federal de 
      Santa Maria, RS, Brazil.
FAU - Duarte, Dr Marta M M F
AU  - Duarte DMMMF
AD  - Centro de Ciencias da Saude, Programa de Pos-Graduacao em Farmacologia, 
      Universidade Federal de Santa Maria, RS.
FAU - da Cruz, Dr Ivana B M
AU  - da Cruz DIBM
AD  - Centro de Ciencias da Saude, Programa de Pos-Graduacao em Farmacologia, 
      Universidade Federal de Santa Maria, RS.
FAU - Moresco, Dr Rafael Noal
AU  - Moresco DRN
AD  - Centro de Ciencias da Saude, Programa de Pos-Graduacao em Farmacologia, 
      Universidade Federal de Santa Maria, RS.
FAU - Dos Santos, Dr Adair Roberto Soares
AU  - Dos Santos DARS
AD  - Centro de Ciencias da Saude, Programa de Pos-Graduacao em Farmacologia, 
      Universidade Federal de Santa Maria, RS.
FAU - Royes, Dr Luiz Fernando Freire
AU  - Royes DLFF
AD  - Centro de Ciencias Naturais e Exatas, Programa de Pos-graduacao em Ciencias 
      Biologicas: Bioquimica Toxicologica, Universidade Federal de Santa Maria, RS; 
      Centro de Educacao Fisica e Desportos, Laboratorio de Bioquimica do Exercicio 
      (BIOEX), Universidade Federal de Santa Maria, RS; Centro de Ciencias da Saude, 
      Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, 
      RS.
FAU - Fighera, Dr Michele Rechia
AU  - Fighera DMR
AD  - Centro de Ciencias da Saude, Departamento de Neuropsiquiatria, Universidade 
      Federal de Santa Maria, RS; Centro de Ciencias Naturais e Exatas, Programa de 
      Pos-graduacao em Ciencias Biologicas: Bioquimica Toxicologica, Universidade 
      Federal de Santa Maria, RS; Centro de Educacao Fisica e Desportos, Laboratorio de 
      Bioquimica do Exercicio (BIOEX), Universidade Federal de Santa Maria, RS; Centro 
      de Ciencias da Saude, Programa de Pos-Graduacao em Farmacologia, Universidade 
      Federal de Santa Maria, RS. Electronic address: mrfighera@yahoo.com.br.
LA  - eng
PT  - Journal Article
DEP - 20180825
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Nitrates)
RN  - 0 (Nitrites)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.15.1.1 (superoxide dismutase 2)
RN  - EC 3.1.1.7 (ACHE protein, human)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - EC 3.4.22.- (CASP3 protein, human)
RN  - EC 3.4.22.- (CASP8 protein, human)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspase 8)
SB  - IM
MH  - Acetylcholinesterase/blood
MH  - Aged
MH  - Apoptosis
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Caspase 3/*blood
MH  - Caspase 8/*blood
MH  - Chronic Disease
MH  - DNA Damage
MH  - Down-Regulation
MH  - Female
MH  - GPI-Linked Proteins/blood
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Middle Aged
MH  - Nitrates/blood
MH  - Nitrites/blood
MH  - Nitrosative Stress
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - Stroke/*blood/diagnosis/enzymology/*genetics
MH  - Superoxide Dismutase/*genetics
MH  - Tumor Necrosis Factor-alpha/*blood
OTO - NOTNLM
OT  - Apoptosis
OT  - BDNF
OT  - Inflammation
OT  - MsSOD Ala16Val polymorphism
OT  - Stroke
EDAT- 2018/08/29 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/08/29 06:00
PHST- 2018/02/23 00:00 [received]
PHST- 2018/06/03 00:00 [revised]
PHST- 2018/06/24 00:00 [accepted]
PHST- 2018/08/29 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/08/29 06:00 [entrez]
AID - S1052-3057(18)30356-2 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2018.06.032 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2018 Nov;27(11):3020-3029. doi: 
      10.1016/j.jstrokecerebrovasdis.2018.06.032. Epub 2018 Aug 25.