PMID- 30150393
OWN - NLM
STAT- MEDLINE
DCOM- 20181005
LR  - 20181114
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 115
IP  - 37
DP  - 2018 Sep 11
TI  - Default mode network can support the level of detail in experience during active 
      task states.
PG  - 9318-9323
LID - 10.1073/pnas.1721259115 [doi]
AB  - Regions of transmodal cortex, in particular the default mode network (DMN), have 
      historically been argued to serve functions unrelated to task performance, in 
      part because of associations with naturally occurring periods of off-task 
      thought. In contrast, contemporary views of the DMN suggest it plays an 
      integrative role in cognition that emerges from its location at the top of a 
      cortical hierarchy and its relative isolation from systems directly involved in 
      perception and action. The combination of these topographical features may allow 
      the DMN to support abstract representations derived from lower levels in the 
      hierarchy and so reflect the broader cognitive landscape. To investigate these 
      contrasting views of DMN function, we sampled experience as participants 
      performed tasks varying in their working-memory load while inside an fMRI 
      scanner. We used self-report data to establish dimensions of thought that 
      describe levels of detail, the relationship to a task, the modality of thought, 
      and its emotional qualities. We used representational similarity analysis to 
      examine correspondences between patterns of neural activity and each dimension of 
      thought. Our results were inconsistent with a task-negative view of DMN function. 
      Distinctions between on- and off-task thought were associated with patterns of 
      consistent neural activity in regions adjacent to unimodal cortex, including 
      motor and premotor cortex. Detail in ongoing thought was associated with patterns 
      of activity within the DMN during periods of working-memory maintenance. These 
      results demonstrate a contribution of the DMN to ongoing cognition extending 
      beyond task-unrelated processing that can include detailed experiences occurring 
      under active task conditions.
CI  - Copyright (c) 2018 the Author(s). Published by PNAS.
FAU - Sormaz, Mladen
AU  - Sormaz M
AUID- ORCID: 0000-0002-3334-7102
AD  - Department of Psychology, University of York, Heslington, York YO10 5DD, United 
      Kingdom; mladen.sormaz@york.ac.uk smallwoodjm@gmail.com.
FAU - Murphy, Charlotte
AU  - Murphy C
AD  - Department of Psychology, University of York, Heslington, York YO10 5DD, United 
      Kingdom.
FAU - Wang, Hao-Ting
AU  - Wang HT
AD  - Department of Psychology, University of York, Heslington, York YO10 5DD, United 
      Kingdom.
FAU - Hymers, Mark
AU  - Hymers M
AD  - Department of Psychology, University of York, Heslington, York YO10 5DD, United 
      Kingdom.
FAU - Karapanagiotidis, Theodoros
AU  - Karapanagiotidis T
AD  - Department of Psychology, University of York, Heslington, York YO10 5DD, United 
      Kingdom.
FAU - Poerio, Giulia
AU  - Poerio G
AD  - Department of Psychology, The University of Sheffield, Western Bank, Sheffield 
      S10 2TN, United Kingdom.
FAU - Margulies, Daniel S
AU  - Margulies DS
AD  - Centre National de la Recherche Scientifique (CNRS) UMR 7225, Frontlab, Institut 
      du Cerveau et de la Moelle Epiniere, Paris, France.
FAU - Jefferies, Elizabeth
AU  - Jefferies E
AD  - Department of Psychology, University of York, Heslington, York YO10 5DD, United 
      Kingdom.
FAU - Smallwood, Jonathan
AU  - Smallwood J
AD  - Department of Psychology, University of York, Heslington, York YO10 5DD, United 
      Kingdom; mladen.sormaz@york.ac.uk smallwoodjm@gmail.com.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180827
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
EIN - Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11198. PMID: 30420509
MH  - Adolescent
MH  - Adult
MH  - Cognition/*physiology
MH  - Emotions/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Motor Cortex/*physiology
MH  - Nerve Net/*physiology
PMC - PMC6140531
OTO - NOTNLM
OT  - default model network
OT  - mind wandering
OT  - principal gradient
OT  - representational similarity analysis
COIS- The authors declare no conflict of interest.
EDAT- 2018/08/29 06:00
MHDA- 2018/10/06 06:00
PMCR- 2018/08/27
CRDT- 2018/08/29 06:00
PHST- 2018/08/29 06:00 [pubmed]
PHST- 2018/10/06 06:00 [medline]
PHST- 2018/08/29 06:00 [entrez]
PHST- 2018/08/27 00:00 [pmc-release]
AID - 1721259115 [pii]
AID - 201721259 [pii]
AID - 10.1073/pnas.1721259115 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9318-9323. doi: 
      10.1073/pnas.1721259115. Epub 2018 Aug 27.