PMID- 30150940
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 9
DP  - 2018
TI  - The Effects of Progressive Resistance Exercise on Recovery Rate of Bone and 
      Muscle in a Rodent Model of Hindlimb Suspension.
PG  - 1085
LID - 10.3389/fphys.2018.01085 [doi]
LID - 1085
AB  - Purpose: This study aimed to examine the exercise-mediated musculoskeletal 
      recovery following hindlimb suspension (HS) in order to identify whether bone 
      modeling and muscle hypertrophy would eventuate in a synchronized manner during 
      recovery stage. Methods: To identify whether 2-week HS would be sufficient to 
      induce a significant reduction of physiological indices in both tibia and 
      adjacent hindlimb muscles, a total of 20 rats was randomized into 2-week HS (n = 
      10) and age-matched control group (n = 10, CON). Another batch of rats were 
      randomly assigned to three different groups to identify recovery intervention 
      effects following suspension: (1) 2-week HS followed by 4-week spontaneous 
      reloading recovery (HRE, n = 7). (2) 2-week HS followed by 4-week progressive 
      resistance ladder climbing exercise (HEX, n = 7). (3) Age-matched control (CON, n 
      = 7). DXA, micro-CT, and (18)F-sodium fluoride (NaF) imaging, and EIA analysis 
      were utilized to measure tibia bone indices. Hindlimb muscle wet weight and grip 
      strength were measured to evaluate muscle mass and strength, respectively. 
      Results: In study 1, bone quality values [bone volume/total volume (BV/TV): -27%, 
      areal bone mineral density (aBMD): -23%, mineral contents: -7.9%, mineral 
      density: -4.1%, and bone density: -38.9%] and skeletal muscle weight (soleus: 
      -46.8%, gastrocnemius: -19.6%, plantaris: -20.8%, TA: -22.8%, and EDL: -9.9%) 
      were significantly lower in HS group compared to CON group. In study 2, micro-CT 
      and DXA-based bone morphology (bone density, BT/TV, and aBMD) were fully 
      recovered in HRE or HEX group. However, suspension-induced dysregulation of bone 
      mineral metabolism was returned to age-matched control group in only HEX group, 
      but not in HRE group. A greater level of biomarkers of bone formation (P1NF) and 
      resorption (CTX-1) was observed in only HRE group compared to CON. The hindlimb 
      skeletal muscle mass was significantly lower in both HRE and HEX groups compared 
      to CON group. Hindlimb grip strength was the greatest in HEX group, followed by 
      CON and HRE groups. Conclusion: Following HS, progressive resistance exercise 
      promotes recovery rates of bone and skeletal muscle strength without a 
      significant increase in muscular mass, suggesting that exercise-induced 
      reacquisition of bone and muscle strength is independent of muscle hypertrophy 
      during early recovery stage.
FAU - Song, Hansol
AU  - Song H
AD  - Health and Exercise Science Laboratory, Institute of Sport Science, Seoul 
      National University, Seoul, South Korea.
FAU - Cho, Suhan
AU  - Cho S
AD  - Health and Exercise Science Laboratory, Institute of Sport Science, Seoul 
      National University, Seoul, South Korea.
FAU - Lee, Ho-Young
AU  - Lee HY
AD  - Department of Nuclear Medicine, Seoul National University Bundang Hospital, 
      Seongnam, South Korea.
FAU - Lee, Hojun
AU  - Lee H
AD  - Department of Rehabilitation Medicine, Seoul National University Bundang 
      Hospital, Seongnam, South Korea.
AD  - Department of Sports and Health Science, Kyungsung University, Busan, South 
      Korea.
FAU - Song, Wook
AU  - Song W
AD  - Health and Exercise Science Laboratory, Institute of Sport Science, Seoul 
      National University, Seoul, South Korea.
AD  - Institute on Aging, Seoul National University, Seoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20180813
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6099092
OTO - NOTNLM
OT  - bone
OT  - hindlimb suspension
OT  - recovery
OT  - resistance exercise
OT  - skeletal muscle
EDAT- 2018/08/29 06:00
MHDA- 2018/08/29 06:01
PMCR- 2018/08/13
CRDT- 2018/08/29 06:00
PHST- 2018/01/26 00:00 [received]
PHST- 2018/07/23 00:00 [accepted]
PHST- 2018/08/29 06:00 [entrez]
PHST- 2018/08/29 06:00 [pubmed]
PHST- 2018/08/29 06:01 [medline]
PHST- 2018/08/13 00:00 [pmc-release]
AID - 10.3389/fphys.2018.01085 [doi]
PST - epublish
SO  - Front Physiol. 2018 Aug 13;9:1085. doi: 10.3389/fphys.2018.01085. eCollection 
      2018.