PMID- 30151097
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 2090-8067 (Print)
IS  - 2042-0072 (Electronic)
VI  - 2018
DP  - 2018
TI  - Metabolic Syndrome and Subclinical Hypothyroidism: A Type 2 Diabetes-Dependent 
      Association.
PG  - 8251076
LID - 10.1155/2018/8251076 [doi]
LID - 8251076
AB  - INTRODUCTION: Subclinical hypothyroidism (ScH) is an endocrine alteration that is 
      related to cardiovascular risk factors, including those categorized as components 
      of the Metabolic Syndrome (MS). However, findings in prior reports regarding an 
      association between these alterations are inconsistent. The purpose of this study 
      was to determine the relationship between both entities in adult subjects from 
      Maracaibo City, Venezuela. MATERIALS AND METHODS: The Maracaibo City Metabolic 
      Syndrome Prevalence Study is a descriptive, cross-sectional study with random and 
      multistage sampling. In this substudy, 391 individuals of both genders were 
      selected and TSH, free T3, and free T4 tests were performed as well as a complete 
      lipid profile, fasting glycaemia, and insulin blood values. ScH was defined 
      according to the National Health and Nutrition Examination Survey (NHANES) 
      criteria: high TSH (>/=4.12mUI/L) and normal free T4 (0.9-1,9 ng/dL) in subjects 
      without personal history of thyroid disease. MS components were defined according 
      to IDF/AHA/NHLBI/WHF/IAS/IASO-2009 criteria. A multiple logistic regression 
      analysis was used to assess the relationship between MS components and ScH 
      diagnosis. RESULTS: Of the evaluated population, 10.5% (n=41) was diagnosed with 
      ScH, with a higher prevalence in women (female: 13.6% versus male: 7.7%; chi2=3.56, 
      p=0.05). Likewise, 56.1% (n=23) of the subjects with ScH were diagnosed with MS 
      (chi2=4.85; p=0.03), being hyperglycemia the main associated criterion (chi2=11.7; 
      p=0.001). In multivariable analysis, it was observed that the relationship was 
      exclusive with the presence of type 2 diabetes mellitus (T2DM) OR: 3.22 
      (1.14-9.14); p=0.03. CONCLUSION: The relationship between ScH and MS in our 
      population is dependent on the presence of hyperglycemia, specifically T2DM 
      diagnosis, findings that vary from those previously reported in Latin American 
      subjects.
FAU - Bermudez, Valmore
AU  - Bermudez V
AUID- ORCID: 0000-0003-1880-8887
AD  - Universidad Simon Bolivar, Facultad de Ciencias de la Salud, Barranquilla, 
      Colombia.
AD  - Endocrine and Metabolic Diseases Research Center, School of Medicine, University 
      of Zulia, Maracaibo, Venezuela.
FAU - Salazar, Juan
AU  - Salazar J
AUID- ORCID: 0000-0003-4211-528X
AD  - Endocrine and Metabolic Diseases Research Center, School of Medicine, University 
      of Zulia, Maracaibo, Venezuela.
FAU - Anez, Roberto
AU  - Anez R
AD  - Endocrine and Metabolic Diseases Research Center, School of Medicine, University 
      of Zulia, Maracaibo, Venezuela.
FAU - Rojas, Milagros
AU  - Rojas M
AD  - Endocrine and Metabolic Diseases Research Center, School of Medicine, University 
      of Zulia, Maracaibo, Venezuela.
FAU - Estrella, Viviana
AU  - Estrella V
AD  - Universidad de Especialidades Espiritu Santo, Canton de Samborondon, Provincia de 
      Guayas, Ecuador.
FAU - Ordonez, Maria
AU  - Ordonez M
AD  - Universidad de Especialidades Espiritu Santo, Canton de Samborondon, Provincia de 
      Guayas, Ecuador.
FAU - Chacin, Maricarmen
AU  - Chacin M
AD  - Endocrine and Metabolic Diseases Research Center, School of Medicine, University 
      of Zulia, Maracaibo, Venezuela.
FAU - Hernandez, Juan Diego
AU  - Hernandez JD
AD  - Grupo de Investigacion Altos Estudios de Frontera (ALEF), Universidad Simon 
      Bolivar, Colombia.
FAU - Arias, Victor
AU  - Arias V
AD  - Grupo de Investigacion Altos Estudios de Frontera (ALEF), Universidad Simon 
      Bolivar, Colombia.
FAU - Cabrera, Mayela
AU  - Cabrera M
AD  - Lone Star College, Biology Department, Tomball, TX 77381, USA.
FAU - Cano-Ponce, Climaco
AU  - Cano-Ponce C
AD  - Endocrine and Metabolic Diseases Research Center, School of Medicine, University 
      of Zulia, Maracaibo, Venezuela.
FAU - Rojas, Joselyn
AU  - Rojas J
AD  - Endocrine and Metabolic Diseases Research Center, School of Medicine, University 
      of Zulia, Maracaibo, Venezuela.
AD  - Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital 
      and Harvard Medical School, Boston, MA 02115, USA.
LA  - eng
PT  - Journal Article
DEP - 20180729
PL  - United States
TA  - J Thyroid Res
JT  - Journal of thyroid research
JID - 101536655
PMC - PMC6087593
EDAT- 2018/08/29 06:00
MHDA- 2018/08/29 06:01
PMCR- 2018/07/29
CRDT- 2018/08/29 06:00
PHST- 2018/02/12 00:00 [received]
PHST- 2018/06/08 00:00 [revised]
PHST- 2018/07/02 00:00 [accepted]
PHST- 2018/08/29 06:00 [entrez]
PHST- 2018/08/29 06:00 [pubmed]
PHST- 2018/08/29 06:01 [medline]
PHST- 2018/07/29 00:00 [pmc-release]
AID - 10.1155/2018/8251076 [doi]
PST - epublish
SO  - J Thyroid Res. 2018 Jul 29;2018:8251076. doi: 10.1155/2018/8251076. eCollection 
      2018.