PMID- 30151303
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2093-6966 (Print)
IS  - 2234-6856 (Electronic)
IS  - 2093-6966 (Linking)
VI  - 21
IP  - 1
DP  - 2018 Mar
TI  - Antidepressant effects of aqueous extract of saffron and its effects on CREB, 
      P-CREB, BDNF, and VGF proteins in rat cerebellum.
PG  - 35-40
LID - 10.3831/KPI.2018.21.005 [doi]
AB  - OBJECTIVE: The role of BDNF (brain-derived neurotrophic factor), CREB (cAMP 
      response element binding) and VGF neuropeptide has been proved in antidepressant 
      activity of long term saffron administration in the rat hippocampus. In this 
      study we evaluated the role of these proteins in antidepressant activity of 
      saffron in long term administration in the rat cerebellum. METHODS: Saffron 
      aqueous extract (40 and 80 mg/kg/day) and imipramine (10 mg/kg/day) were 
      administered intraperitoneally for 21 days to rats. At the end of experiment, 
      animals were sacrificed and cerebellums were separated. The protein levels of 
      BDNF, VGF, CREB and P- CREB in the rat cerebellum were evaluated using western 
      blot analysis. RESULTS: Saffron aqueous extract (80mg/kg/day) caused significant 
      increase in protein level of P-CREB in long term treatment in the rat cerebellum. 
      The increases in the protein levels of VGF, CREB and BDNF were not significant. 
      CONCLUSION: In summary, our results showed that antidepressant effect of saffron 
      in rat cerebellum might be due to the enhanced phosphorylation of CREB.
FAU - Asrari, Najmeh
AU  - Asrari N
AD  - School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Yazdian-Robati, Rezvan
AU  - Yazdian-Robati R
AD  - Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Abnous, Khalil
AU  - Abnous K
AD  - Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
AD  - Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Razavi, BiBi Marjan
AU  - Razavi BM
AD  - Targeted Drug Delivery Research Center, Department of Pharmacology and 
      Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Rashednia, Mrazieh
AU  - Rashednia M
AD  - Department of Toxicology and pharmacology, School of Pharmacy, International 
      branch, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Hasani, Faezeh Vahdati
AU  - Hasani FV
AD  - School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Hosseinzadeh, Hossein
AU  - Hosseinzadeh H
AD  - School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
AD  - Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
AD  - Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
AD  - Targeted Drug Delivery Research Center, Department of Pharmacology and 
      Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
AD  - Department of Toxicology and pharmacology, School of Pharmacy, International 
      branch, Shiraz University of Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20180331
PL  - Korea (South)
TA  - J Pharmacopuncture
JT  - Journal of pharmacopuncture
JID - 101572812
PMC - PMC6054076
OTO - NOTNLM
OT  - BDNF
OT  - CREB
OT  - Cerebellum
OT  - Crocus sativus
OT  - Depression
OT  - P-CREB
OT  - VGF
COIS- Conflict of interest The authors have declared no conflict of interest.
EDAT- 2018/08/29 06:00
MHDA- 2018/08/29 06:01
PMCR- 2018/03/01
CRDT- 2018/08/29 06:00
PHST- 2017/05/10 00:00 [received]
PHST- 2018/02/14 00:00 [revised]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/08/29 06:00 [entrez]
PHST- 2018/08/29 06:00 [pubmed]
PHST- 2018/08/29 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - kpi-21-035 [pii]
AID - 10.3831/KPI.2018.21.005 [doi]
PST - ppublish
SO  - J Pharmacopuncture. 2018 Mar;21(1):35-40. doi: 10.3831/KPI.2018.21.005. Epub 2018 
      Mar 31.