PMID- 30153658
OWN - NLM
STAT- MEDLINE
DCOM- 20191216
LR  - 20191217
IS  - 1423-0194 (Electronic)
IS  - 0028-3835 (Linking)
VI  - 108
IP  - 1
DP  - 2019
TI  - Unmet Needs in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms (WHO 
      G3).
PG  - 54-62
LID - 10.1159/000493318 [doi]
AB  - Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are classified based 
      on morphology and graded based on their proliferation rate as either 
      well-differentiated low-grade (G1 to G2) neuroendocrine tumors (NET) or poorly 
      differentiated high-grade (G3) neuroendocrine carcinomas (NEC). Recently, a new 
      subgroup of well-differentiated high-grade pancreatic tumors (NET G3) has been 
      defined. The GEP NEN G3 group consisting of both NEC and NET G3 has recently been 
      shown to be a quite heterogeneous patient group concerning prognosis and 
      treatment benefit, depending on factors such as the primary tumor site, 
      differentiation, proliferation rate, and molecular alterations. In this review we 
      discuss the existing data on diagnostics, treatment, and biomarkers in this 
      patient group, the unmet needs, and the future perspectives.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Sorbye, Halfdan
AU  - Sorbye H
AD  - Department of Oncology and Clinical Science, Haukeland University Hospital, 
      Bergen, Norwayhalfdan.sorbye@helse-bergen.no.
FAU - Baudin, Eric
AU  - Baudin E
AD  - Endocrine Oncology, Gustave Roussy, Villejuif, France.
FAU - Borbath, Ivan
AU  - Borbath I
AD  - Hepato-Gastroenterology Unit, Cliniques Universitaires Saint-Luc, Bruxelles, 
      Belgium.
FAU - Caplin, Martyn
AU  - Caplin M
AD  - Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 
      London, United Kingdom.
FAU - Chen, Jie
AU  - Chen J
AD  - Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, China.
FAU - Cwikla, Jaroslaw B
AU  - Cwikla JB
AD  - Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland.
FAU - Frilling, Andrea
AU  - Frilling A
AD  - Department of Surgery and Cancer, Imperial College London, London, United 
      Kingdom.
FAU - Grossman, Ashley
AU  - Grossman A
AD  - Neuroendocrine Tumour Unit, Royal Free Hospital, London, United Kingdom.
FAU - Kaltsas, Gregory
AU  - Kaltsas G
AD  - National and Kapodistrian University of Athens, Athens, Greece.
FAU - Scarpa, Aldo
AU  - Scarpa A
AD  - ARC-Net Centre for Applied Research on Cancer and Section of Pathology of the 
      Department of Diagnostics and Public Health, University and Hospital Trust of 
      Verona, Verona, Italy.
FAU - Welin, Staffan
AU  - Welin S
AD  - Department of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden.
FAU - Garcia-Carbonero, Rocio
AU  - Garcia-Carbonero R
AD  - Oncology Department, Hospital Universitario 12 de Octubre, CNIO, CIBERONC, 
      Universidad Complutense de Madrid, Madrid, Spain.
CN  - ENETS 2016 Munich Advisory Board Participants
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180828
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Biomedical Research/trends
MH  - *Gastrointestinal Neoplasms/diagnosis/drug therapy/metabolism
MH  - Humans
MH  - *Neuroendocrine Tumors/diagnosis/drug therapy/metabolism
MH  - *Pancreatic Neoplasms/diagnosis/drug therapy/metabolism
OTO - NOTNLM
OT  - Neuroendocrine carcinoma
OT  - Neuroendocrine neoplasm
OT  - Neuroendocrine tumor
FIR - Bartsch, Detlef
IR  - Bartsch D
IRAD- UKGM GmbH, Marburg, Germany.
FIR - Arnold, Rudolf
IR  - Arnold R
IRAD- University Hospital, Marburg, Germany.
FIR - Baudin, Eric
IR  - Baudin E
IRAD- Institut Gustave, Roussy, France.
FIR - Bodei, Lisa
IR  - Bodei L
IRAD- Memorial Sloan Kettering Cancer Center, USA.
FIR - Borbath, Ivan
IR  - Borbath I
IRAD- Cliniques universitaires, Saint-Luc, Belgium.
FIR - Capdevila, Jaume
IR  - Capdevila J
IRAD- Vall d'Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), 
      Spain.
FIR - Caplin, Martyn
IR  - Caplin M
IRAD- Department of Medicine, Royal Free Hospital, UK.
FIR - Chen, Jie
IR  - Chen J
IRAD- The First Affiliated Hospital, Sun Yat-Sen University, China.
FIR - Costa, Frederico
IR  - Costa F
IRAD- Oncoclin Medicos Associados S/S Ltda. c/o Frederico Costa - Regina Lima, Brazil.
FIR - Couvelard, Anne
IR  - Couvelard A
IRAD- Hopital Bichat, Service de Pathologie, France.
FIR - Cwikla, Jaroslaw
IR  - Cwikla J
IRAD- Department of Radiology, Faculty of Medical Sciences, Univeristy of Warmia and 
      Mazury, Poland.
FIR - Davies, Philippa
IR  - Davies P
FIR - de, Herder
IR  - de H
IRAD- Erasmus MC, Department of Internal Medicine, Section of Endocrinology, The 
      Netherlands.
FIR - Falconi, Massimo
IR  - Falconi M
IRAD- Department of Surgery, Universita Vita e Salute, Italy.
FIR - Falkerby, Jenny
IR  - Falkerby J
IRAD- Department of Endocrine Oncology, Uppsala University Hospital, Sweden.
FIR - Fazio, Nicola
IR  - Fazio N
IRAD- European Institute of Oncology, Italy.
FIR - Ferone, Diego
IR  - Ferone D
IRAD- University of Genova, Italy.
FIR - Frilling, Andrea
IR  - Frilling A
IRAD- Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, 
      UK.
FIR - Garcia-Carbonero, Rocio
IR  - Garcia-Carbonero R
IRAD- Hospital Universitario Doce de Octubre, Spain.
FIR - Glasberg, Simona
IR  - Glasberg S
FIR - Gorbunova, Vera
IR  - Gorbunova V
FIR - Grossman, Ashley
IR  - Grossman A
IRAD- Royal Free Hospital, London, UK.
FIR - Horsch, Dieter
IR  - Horsch D
IRAD- Zentralklinik Bad Berka GmbH, CA Gastroenterologie, Germany.
FIR - Jensen, Robert
IR  - Jensen R
IRAD- National Institutes of Health, USA.
FIR - Kaltsas, Gregory
IR  - Kaltsas G
IRAD- Endocrine Unit, Department of Pathophysiology, National University of Athens, 
      Greece.
FIR - Kloppel, Gunter
IR  - Kloppel G
IRAD- Consultation Center for Pancreatic and Endocrine Tumors/Department of 
      Pathology/TU-Munich, Germany.
FIR - Knigge, Ulrich
IR  - Knigge U
IRAD- Rigshospitalet, Department of Surgery (C2122), Denmark.
FIR - Kos-Kudla, Beata
IR  - Kos-Kudla B
IRAD- Department of Endocrinology and Neuroendocrine Tumors, Medical University of 
      Silesia, Poland.
FIR - Krejs, Guenter
IR  - Krejs G
IRAD- Universitatsklinik fur Innere Medizin, Austria.
FIR - Krenning, Eric
IR  - Krenning E
IRAD- Erasmus MC, The Netherlands.
FIR - Kulke, Matthew
IR  - Kulke M
IRAD- Dana-Farber Cancer Institute, USA.
FIR - Lamberts, Steven
IR  - Lamberts S
FIR - Nieveen, van
IR  - Nieveen V
IRAD- Amsterdam Working Hospital, The Netherlands.
FIR - O'Connor, Juan
IR  - O'Connor J
IRAD- Instituto Fleming, Argentina.
FIR - O'Toole, Dermot
IR  - O'Toole D
IRAD- St. James's and St Vincnt's Univerrsity Hospitals and Trinity College Dublin, 
      Ireland.
FIR - Pape, Ulrich-Frank
IR  - Pape UF
IRAD- Charite Campus Mitte, Berlin, Germany.
FIR - Partelli, Stefano
IR  - Partelli S
IRAD- Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San 
      Raffaele Scientific Institute, "Vita-Salute" University, Milan, Italy.
FIR - Pavel, Marianne
IR  - Pavel M
IRAD- Universitatsklinikum Erlangen, Germany.
FIR - Peeters, Marc
IR  - Peeters M
IRAD- Department of Oncology, Antwerp University Hospital, Belgium.
FIR - Ramage, John
IR  - Ramage J
IRAD- Hampshire Hospitals NHS Trust, UK.
FIR - Reed, Nicholas
IR  - Reed N
IRAD- Beatson Oncology Centre/Gartnavel General Hospital, UK.
FIR - Rindi, Guido
IR  - Rindi G
IRAD- Policlinico Universitario A. Gemelli, Rome, Italy.
FIR - Rinke, Anja
IR  - Rinke A
IRAD- Uniklinikum Giessen und Marburg, Germany.
FIR - Ruszniewski, Philippe
IR  - Ruszniewski P
IRAD- Department of Gastroenterology-Pancreatology, Beaujon Hospital, France.
FIR - Sorbye, Halfdan
IR  - Sorbye H
IRAD- Haukeland University Hospital, Department of Oncology, Norway.
FIR - Sundin, Anders
IR  - Sundin A
IRAD- Department of Radiology, Institute of Surgical Sciences, Uppsala University, 
      Akademiska Sjukhuset, Uppsala, Sweden.
FIR - Scoazec, Jean-Yves
IR  - Scoazec JY
IRAD- Gustave Roussy, Biopathology, France.
FIR - Taal, Babs
IR  - Taal B
IRAD- Netherlands Cancer Centre, The Netherlands.
FIR - Tiensuu, Janson
IR  - Tiensuu J
IRAD- Uppsala University, Sweden.
FIR - Toumpanakis, Christos
IR  - Toumpanakis C
IRAD- Royal Free Hospital, London, UK.
FIR - Valle, Juan
IR  - Valle J
IRAD- University of Manchester/The Christie NHS Foundation Trust, UK.
FIR - Vullierme, Marie-Pierre
IR  - Vullierme MP
IRAD- Hopital Beaujon - Radiologie, France.
FIR - Welin, Staffan
IR  - Welin S
IRAD- Endocrine Oncology, University Hospital, Uppsala, Sweden.
FIR - Wiedenmann, Bertram
IR  - Wiedenmann B
IRAD- Gastroenterology, Charite Medical School and Hospital (Virchow), Germany.
EDAT- 2018/08/29 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/08/29 06:00
PHST- 2018/06/26 00:00 [received]
PHST- 2018/08/27 00:00 [accepted]
PHST- 2018/08/29 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/08/29 06:00 [entrez]
AID - 000493318 [pii]
AID - 10.1159/000493318 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2019;108(1):54-62. doi: 10.1159/000493318. Epub 2018 Aug 28.