PMID- 30153660
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20190111
IS  - 1421-9859 (Electronic)
IS  - 0378-5866 (Linking)
VI  - 40
IP  - 3
DP  - 2018
TI  - Different Developmental Pattern of Brain Activities in ADHD: A Study of 
      Resting-State fMRI.
PG  - 246-257
LID - 10.1159/000490289 [doi]
AB  - There are distinct symptoms for attention deficit hyperactivity disorder (ADHD) 
      at different ages. To explore the developmental mechanism of ADHD from childhood 
      to adolescence, patients from different age groups with ADHD drawn from a large 
      dataset should be investigated. In this study, we hypothesized that there are 
      significant differences in the developmental patterns of local and global brain 
      activities between ADHD and typically developing (TD) individuals. Three 
      voxel-based measurements and the functional connectivity (FC) of the brain 
      networks were extracted from resting-state functional magnetic resonance imaging 
      (fMRI) of both ADHD and TD participants 7-16 years of age. The topological 
      properties of brain networks in both groups were also analyzed, including hubs, 
      hemispheric symmetry, together with local and global efficiency. The results 
      showed, from the local perspective, that the ADHD group had abnormal amplitude of 
      low-frequency fluctuation, fractional amplitude of low-frequency fluctuation, and 
      regional homogeneity in the medial orbital frontal cortex, anterior cingulate 
      cortex, postcentral gyrus, thalamus, precuneus, and cerebellum compared with the 
      TD group. From the global perspective, the aberrant FC between multiple networks, 
      such as the default mode network (DMN), the attention network, and the executive 
      control network, might directly contribute to symptom differences in childhood 
      and adolescence in ADHD patients. Finally, from the developmental perspective, 
      there was delayed maturation of brain networks in the ADHD group, especially in 
      the DMN. Overall, we presented the differences in brain networks between the ADHD 
      and TD group from multiple perspectives and demonstrated the developmental 
      abnormality of brain networks in ADHD patients, contributing to the study of the 
      etiology of ADHD.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Tang, Chao
AU  - Tang C
FAU - Wei, Yuqing
AU  - Wei Y
FAU - Zhao, Jiajia
AU  - Zhao J
FAU - Nie, Jingxin
AU  - Nie J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180713
PL  - Switzerland
TA  - Dev Neurosci
JT  - Developmental neuroscience
JID - 7809375
SB  - IM
MH  - Adolescent
MH  - Attention/physiology
MH  - Attention Deficit Disorder with Hyperactivity/*physiopathology
MH  - *Brain Mapping/methods
MH  - Cerebellum/physiopathology
MH  - Child
MH  - Gyrus Cinguli/*physiopathology
MH  - Humans
MH  - *Magnetic Resonance Imaging/methods
MH  - Neural Pathways/*physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Attention deficit hyperactivity disorder (ADHD)
OT  - Brain development
OT  - Functional connectivity
OT  - Resting-state functional magnetic resonance imaging (rs-fMRI)
OT  - Topological property
EDAT- 2018/08/29 06:00
MHDA- 2019/01/12 06:00
CRDT- 2018/08/29 06:00
PHST- 2018/01/22 00:00 [received]
PHST- 2018/05/03 00:00 [accepted]
PHST- 2018/08/29 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2018/08/29 06:00 [entrez]
AID - 000490289 [pii]
AID - 10.1159/000490289 [doi]
PST - ppublish
SO  - Dev Neurosci. 2018;40(3):246-257. doi: 10.1159/000490289. Epub 2018 Jul 13.