PMID- 30155467
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 5
DP  - 2018
TI  - The Genetics of Pemphigus Vulgaris.
PG  - 226
LID - 10.3389/fmed.2018.00226 [doi]
LID - 226
AB  - Pemphigus vulgaris (PV) is a severe autoimmune blistering disease caused by 
      auto-antibodies (auto-Abs) directed against epithelial desmosomal components and 
      leading to disruption of cell-cell adhesion. The exact mechanisms underlying the 
      disease pathogenesis remain unknown and treatment is still based on 
      immunosuppressive drugs, such as corticosteroids, which are associated with 
      potentially significant side effects. Ethnic susceptibility, familial occurrence, 
      and autoimmune comorbidity, suggest a genetic component to the pathogenesis of 
      the disease, which, if discovered, could advance our understanding of PV 
      pathogenesis and thereby point to novel therapeutic targets for this 
      life-threatening disorder. In this article, we review the evidence for a genetic 
      basis of PV, summarize the different approaches used to investigate 
      susceptibility traits for the disease and describe past and recent discoveries 
      regarding genes associated with PV, most of which belong to the human leukocyte 
      antigen (HLA) locus with limited data regarding association of non-HLA genes with 
      the disease.
FAU - Vodo, Dan
AU  - Vodo D
AD  - Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
AD  - Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of 
      Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Sarig, Ofer
AU  - Sarig O
AD  - Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of 
      Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Sprecher, Eli
AU  - Sprecher E
AD  - Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
AD  - Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of 
      Medicine, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180814
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC6102399
OTO - NOTNLM
OT  - HLA
OT  - autoimmunity
OT  - blistering disorders
OT  - genetics
OT  - pemphigus
EDAT- 2018/08/30 06:00
MHDA- 2018/08/30 06:01
PMCR- 2018/08/14
CRDT- 2018/08/30 06:00
PHST- 2018/06/01 00:00 [received]
PHST- 2018/07/25 00:00 [accepted]
PHST- 2018/08/30 06:00 [entrez]
PHST- 2018/08/30 06:00 [pubmed]
PHST- 2018/08/30 06:01 [medline]
PHST- 2018/08/14 00:00 [pmc-release]
AID - 10.3389/fmed.2018.00226 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2018 Aug 14;5:226. doi: 10.3389/fmed.2018.00226. 
      eCollection 2018.