PMID- 30155660
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20210109
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 34
IP  - 2
DP  - 2019 Feb
TI  - Development of suction force during early diastole from the left atrium to the 
      left ventricle in infants, children, and adolescents.
PG  - 296-306
LID - 10.1007/s00380-018-1239-9 [doi]
AB  - Although the suction force that moves blood into the left ventricle during early 
      diastole is thought to play an important role in diastolic function, there have 
      been a few studies of this phenomenon in normal children. Suction force is 
      measured as the intraventricular pressure difference (IVPD) and intraventricular 
      pressure gradient (IVPG), which is calculated as IVPD divided by left ventricular 
      length. The purpose of this study was to determine the suction force in infants, 
      children, and adolescents using IVPD and IVPG. We included 120 normal children 
      categorized into five groups based on age: G1 (0-2 years), G2 (3-5 years), G3 
      (6-8 years), G4 (9-11 years), and G5 (12-16 years). The total, basal, and 
      mid-apical IVPD and IVPG were calculated using color M-mode Doppler imaging of 
      the mitral valve inflow using the Euler equation. The total IVPD increased with 
      age from G1 to G5 (1.75 + 0.51 vs. 2.95 + 0.72 mmHg, respectively; p < 0.001), 
      due to an increase in mid-apical IVPD with constant basal IVPD. Although total 
      IVPG was constant, mid-apical IVPG was larger in G5 than in G1 (0.21 + 0.06 vs. 
      0.16 + 0.07 mmHg/cm, respectively; p = 0.006). Total, basal, and mid-apical IVPDs 
      were significantly correlated with age and the parameters of heart size and 
      mitral annular e'. Mid-apical IVPG correlated with age and e' positively, but 
      basal IVPG did with age negatively and did not with e'. The suction force 
      increased at the mid-apical segment, correlating with increasing heart size and 
      developing left ventricular relaxation, even after adjustment for left 
      ventricular length.
FAU - Takahashi, Ken
AU  - Takahashi K
AUID- ORCID: 0000-0002-9592-4200
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, 3-1-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8421, Japan. kentaka@juntendo.ac.jp.
FAU - Nii, Masaki
AU  - Nii M
AD  - Department of Cardiology, Shizuoka Children's Hospital, 860 Urushiyama Aoi-ku, 
      Shizuoka, 420-0953, Japan.
FAU - Takigiku, Kiyohiro
AU  - Takigiku K
AD  - Department of Pediatric Cardiology, Nagano Children's Hospital, 3100 Toyoshina 
      Azunimo-shi, Nagano, 399-8288, Japan.
FAU - Toyono, Manatomo
AU  - Toyono M
AD  - Department of Pediatrics, Graduate School of Medicine, Organ Function-Oriented 
      Medicine, Akita University, 1-1-1 Hondou Akita-shi, Akita, 010-8543, Japan.
FAU - Iwashima, Satoru
AU  - Iwashima S
AD  - Department of Pediatrics, Chutoen General Medical Cente, 1-1 Shoubugaike, 
      Kakegawa-shi, Shizuoka, 436-0040, Japan.
FAU - Inoue, Nao
AU  - Inoue N
AD  - Department of Pediatrics, Seirei Hamamatsu General Hospital, 2-12-12 Sueyoshi, 
      Nakaku, Hamamatsu-shi, Shizuoka, 430-8558, Japan.
FAU - Tanaka, Noboru
AU  - Tanaka N
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, 3-1-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8421, Japan.
FAU - Matsui, Kotoko
AU  - Matsui K
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, 3-1-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8421, Japan.
FAU - Shigemitsu, Sachie
AU  - Shigemitsu S
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, 3-1-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8421, Japan.
FAU - Yamada, Mariko
AU  - Yamada M
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, 3-1-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8421, Japan.
FAU - Kobayashi, Maki
AU  - Kobayashi M
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, 3-1-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8421, Japan.
FAU - Yazaki, Kana
AU  - Yazaki K
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, 3-1-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8421, Japan.
FAU - Itatani, Keiichi
AU  - Itatani K
AD  - Department of Cardiovascular Surgery, Cardiovascular Imaging Research Laboratory, 
      Kyoto Prefectural University of Medicine, 465 Kajicho, Hirokoji, Kawaracho 
      Kamigyo-ku, Kyoto-shi, Kyoto, 602-8526, Japan.
FAU - Shimizu, Toshiaki
AU  - Shimizu T
AD  - Department of Pediatrics, Juntendo University Faculty of Medicine, 3-1-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8421, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180828
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
SB  - IM
MH  - Adolescent
MH  - Atrial Function, Left/*physiology
MH  - Child
MH  - Child, Preschool
MH  - Diastole
MH  - Echocardiography, Doppler, Color/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Atria/*diagnostic imaging
MH  - Heart Ventricles/*diagnostic imaging
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Prospective Studies
MH  - Reference Values
MH  - Ventricular Function, Left/*physiology
MH  - Ventricular Pressure/*physiology
OTO - NOTNLM
OT  - Diastolic function
OT  - Echocardiography
OT  - Intraventricular pressure difference
OT  - Intraventricular pressure gradient
EDAT- 2018/08/30 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/08/30 06:00
PHST- 2017/12/29 00:00 [received]
PHST- 2018/08/17 00:00 [accepted]
PHST- 2018/08/30 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/08/30 06:00 [entrez]
AID - 10.1007/s00380-018-1239-9 [pii]
AID - 10.1007/s00380-018-1239-9 [doi]
PST - ppublish
SO  - Heart Vessels. 2019 Feb;34(2):296-306. doi: 10.1007/s00380-018-1239-9. Epub 2018 
      Aug 28.