PMID- 3015659
OWN - NLM
STAT- MEDLINE
DCOM- 19860917
LR  - 20190722
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 93
IP  - 2
DP  - 1986 Aug
TI  - Opiate-induced seizures: a study of mu and delta specific mechanisms.
PG  - 348-58
AB  - Two groups of experiments were conducted to determine if morphine- and 
      enkephalin-induced seizures are specifically mediated by the mu and delta 
      receptor, respectively. In the first experiments, designed to assess the ontogeny 
      of mu- or delta-seizures, rats from 6 h to 85 days of age received implanted 
      cortical and depth electrodes as well as an indwelling cannula in the lateral 
      ventricle. Various amounts of the mu-receptor agonists, morphine and 
      morphiceptin, and the delta agonists, D-Ala2-D-Leu5-enkephalin (DADL) and 
      Tyr-D-Ser-Gly-Phe-Leu-Thr (DSLET), were then administered 
      intracerebroventricularly (icv) with continuous EEG monitoring. The second 
      experiments entailed use of the nonspecific opiate antagonist, naloxone, as well 
      as the specific delta antagonist, ICI 154,129, against seizures induced by 
      icv-administered morphine, morphiceptin, DADL, or DSLET. Both morphine and 
      morphiceptin produced electrical seizure activity in rats as young as 5 days 
      after birth. The drugs produced similar seizure activity in terms of electrical 
      morphology, observed behavior, ontogeny, threshold dose, and reversibility with 
      small doses of naloxone. In the pharmacologic experiments, icv naloxone blocked 
      all opiate-induced seizures. ICI 154,129 blocked DSLET seizure, had little effect 
      on enkephalin or DADL seizures, and no effect on morphine or morphiceptin 
      seizures. These data indicate that DSLET seizures are delta-specific but that all 
      other opiate-induced seizures studied may involve multiple opiate 
      receptor-mediated mechanisms.
FAU - Snead, O C 3rd
AU  - Snead OC 3rd
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Endorphins)
RN  - 0 (Narcotics)
RN  - 0 (Oligopeptides)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Opioid, delta)
RN  - 0 (Receptors, Opioid, mu)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 63631-40-3 (Enkephalin, Leucine-2-Alanine)
RN  - 75644-90-5 (enkephalin, Ser(2), Leu(5), Thr(6)-)
RN  - 76I7G6D29C (Morphine)
RN  - 97BUE7NR2M (ICI 154129)
RN  - 97TZA8ANPC (morphiceptin)
SB  - IM
MH  - Animals
MH  - Electroencephalography
MH  - Endorphins/pharmacology
MH  - Enkephalin, Leucine/analogs & derivatives/pharmacology
MH  - Enkephalin, Leucine-2-Alanine
MH  - Morphine/pharmacology
MH  - Narcotics/*pharmacology
MH  - Oligopeptides/antagonists & inhibitors/pharmacology
MH  - Rats
MH  - Receptors, Opioid/*physiology
MH  - Receptors, Opioid, delta
MH  - Receptors, Opioid, mu
MH  - Seizures/*chemically induced/physiopathology
EDAT- 1986/08/01 00:00
MHDA- 1986/08/01 00:01
CRDT- 1986/08/01 00:00
PHST- 1986/08/01 00:00 [pubmed]
PHST- 1986/08/01 00:01 [medline]
PHST- 1986/08/01 00:00 [entrez]
AID - 0014-4886(86)90195-0 [pii]
AID - 10.1016/0014-4886(86)90195-0 [doi]
PST - ppublish
SO  - Exp Neurol. 1986 Aug;93(2):348-58. doi: 10.1016/0014-4886(86)90195-0.