PMID- 30156820
OWN - NLM
STAT- MEDLINE
DCOM- 20190329
LR  - 20190329
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 10
IP  - 38
DP  - 2018 Sep 26
TI  - Inorganic Nanomaterials as Highly Efficient Inhibitors of Cellular Hepatic 
      Fibrosis.
PG  - 31938-31946
LID - 10.1021/acsami.8b10527 [doi]
AB  - Chronic liver dysfunction usually begins with hepatic fibrosis. To date, no 
      effective anti-fibrotic drugs have been approved for clinical use in humans. In 
      the current work, titanium dioxide (TiO(2)) nanoparticles (NPs) and silicon 
      dioxide (SiO(2)) NPs are used as active inhibitors with intrinsic chemico-physico 
      properties to block fibrosis and the associated phenotypes through acting on 
      hepatic stellate cells (HSCs, the liver machinery for depositing scar tissues 
      seen in fibrosis). Using LX-2 cells as the HSC model, internalized nanomaterials 
      are found to suppress classical outcomes of cellular fibrosis, for example, 
      inhibiting the expression of collagen I (Col-I) and alpha smooth muscle actin 
      (alpha-SMA), initiated by transforming growth factor beta (TGF-beta)-activated HSCs in both 
      a concentration-dependent and a time-dependent manner. Biochemically, these 
      nanomaterials could also facilitate the proteolytic breakdown of collagen by 
      up-regulation of matrix metalloproteinases (MMPs) and down-regulation of tissue 
      inhibitors of MMPs (TIMPs). Furthermore, through regulating 
      epithelial-mesenchymal transition (EMT) genes [e.g., E-cadherin (E-Cad) and 
      N-cadherin (N-Cad)], the adhesion and migration profiles of TGF-beta-activated LX-2 
      cells treated with nanomaterials were further inhibited, reverting them to a more 
      quiescent state. Thus, the collective results pave the new way that nanomaterials 
      can be used as potential therapeutic inhibitors for the treatment of in vivo 
      fibrosis.
FAU - Peng, Fei
AU  - Peng F
AD  - Department of Pharmacy, Faculty of Science , National University of Singapore , 
      18 Science Drive 4 , Singapore 117543 , Singapore.
FAU - Tee, Jie Kai
AU  - Tee JK
AD  - Department of Pharmacy, Faculty of Science , National University of Singapore , 
      18 Science Drive 4 , Singapore 117543 , Singapore.
AD  - NUS Graduate School for Integrative Sciences & Engineering , Centre for Life 
      Sciences , 28 Medical Drive , Singapore 117456 , Singapore.
FAU - Setyawati, Magdiel Inggrid
AU  - Setyawati MI
AD  - Department of Chemical and Biomolecular Engineering , National University of 
      Singapore , 4 Engineering Drive 4 , Singapore 117585 , Singapore.
FAU - Ding, Xianguang
AU  - Ding X
AD  - Department of Chemical and Biomolecular Engineering , National University of 
      Singapore , 4 Engineering Drive 4 , Singapore 117585 , Singapore.
FAU - Yeo, Hui Ling Angie
AU  - Yeo HLA
AD  - Department of Pharmacy, Faculty of Science , National University of Singapore , 
      18 Science Drive 4 , Singapore 117543 , Singapore.
FAU - Tan, Yeong Lan
AU  - Tan YL
AD  - Department of Pharmacy, Faculty of Science , National University of Singapore , 
      18 Science Drive 4 , Singapore 117543 , Singapore.
AD  - NUS Graduate School for Integrative Sciences & Engineering , Centre for Life 
      Sciences , 28 Medical Drive , Singapore 117456 , Singapore.
FAU - Leong, David Tai
AU  - Leong DT
AUID- ORCID: 0000-0001-8539-9062
AD  - Department of Chemical and Biomolecular Engineering , National University of 
      Singapore , 4 Engineering Drive 4 , Singapore 117585 , Singapore.
FAU - Ho, Han Kiat
AU  - Ho HK
AUID- ORCID: 0000-0003-0614-3048
AD  - Department of Pharmacy, Faculty of Science , National University of Singapore , 
      18 Science Drive 4 , Singapore 117543 , Singapore.
LA  - eng
PT  - Journal Article
DEP - 20180911
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Actins)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 9007-34-5 (Collagen)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Actins/genetics
MH  - Cell Line
MH  - Collagen/genetics
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Gene Expression/drug effects
MH  - Hepatic Stellate Cells/*drug effects
MH  - Humans
MH  - Liver Cirrhosis/*drug therapy
MH  - Nanostructures/*chemistry
MH  - Silicon Dioxide/chemistry/*pharmacology
MH  - Titanium/chemistry/*pharmacology
OTO - NOTNLM
OT  - fibrosis
OT  - hepatic stellate cells
OT  - nanoparticles
OT  - silicon dioxide
OT  - titanium dioxide
EDAT- 2018/08/30 06:00
MHDA- 2019/03/30 06:00
CRDT- 2018/08/30 06:00
PHST- 2018/08/30 06:00 [pubmed]
PHST- 2019/03/30 06:00 [medline]
PHST- 2018/08/30 06:00 [entrez]
AID - 10.1021/acsami.8b10527 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2018 Sep 26;10(38):31938-31946. doi: 
      10.1021/acsami.8b10527. Epub 2018 Sep 11.