PMID- 30157337
OWN - NLM
STAT- MEDLINE
DCOM- 20181212
LR  - 20181212
IS  - 1110-0583 (Print)
IS  - 1110-0583 (Linking)
VI  - 47
IP  - 1
DP  - 2017 Apr
TI  - TWIST2 EXPRESSIONS IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE URINARY 
      BLADDER SHOWED DOWN REGULATION CORRELATED WITH GOOD SURVIVAL AND LOW INCIDENCE OF 
      DISTANT METASTASIS.
PG  - 101-105
AB  - This study evaluated the association between expression of Twist2 monogenic, with 
      pathological features and clinical outcomes of squamous cell carcinoma of the 
      urinary bladder (SCCUB) following radical cystectomy (RC). Immunohistochemical 
      staining Twist2 was performed on tissue archival samples comprising normal 
      urothelium from ten controls, cystectomy specimens from 87, patients with T2 NO 
      MO and T3-4a NO MO of bladder squamous cell carcinoma (SCC).all patients with 
      T2-4 SCC undergone radical cystectomy and urinary diversion, follow up was for 
      5-10 years to assess overall survival (OS) and disease free survival (DFS). 
      Specimens from 10 muscle-invasive urothelial carcinoma patients were reassessed 
      for Twist2 expression to represent over- expression of Twist2. All ten controls 
      had normal status of biomarkers which was negative. Negative or, low, and medium 
      expression of Twist2 was noted in SCC of the urinary bladder of local 
      pathological status with no lymph node metastasis or distant metastasis, 
      clinicopathologic characteristics of the cohort were pT2NO MO (n=659 and pT3-4a 
      NO MO (n= 22). Twist2 negative expression was in 36 case, weak expression (n=33), 
      medium expression (n=16), there were no strong expression. Twist2 low-regulation 
      with combination of tomor stage in SCC of the urinary bladder werel independently 
      associated with overall survival and free disease survival, 7.7 and 5 years 
      survival in pT2 NO MO(n=65) were 89% and 13% respectively, 7.7 and 5 years 
      survival in pT3-4a NO MO(n=22) were 72.7% and 22.7% respectively.
FAU - Wishahi, Mohamed
AU  - Wishahi M
FAU - Khalil, Heba
AU  - Khalil H
FAU - Kamel, Noura
AU  - Kamel N
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - J Egypt Soc Parasitol
JT  - Journal of the Egyptian Society of Parasitology
JID - 8102141
RN  - 0 (Repressor Proteins)
RN  - 0 (TWIST2 protein, human)
RN  - 0 (Twist-Related Protein 1)
RN  - EC 2.7.10.1 (FGFR3 protein, human)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 3)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/metabolism/mortality/*pathology/secondary
MH  - Cohort Studies
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Receptor, Fibroblast Growth Factor, Type 3/genetics/metabolism
MH  - Repressor Proteins/genetics/*metabolism
MH  - Retrospective Studies
MH  - Schistosomiasis haematobia/complications/pathology
MH  - Survival Analysis
MH  - Twist-Related Protein 1/genetics/*metabolism
MH  - Urinary Bladder Neoplasms/etiology/metabolism/mortality/*pathology
EDAT- 2017/04/01 00:00
MHDA- 2018/12/13 06:00
CRDT- 2018/08/30 06:00
PHST- 2018/08/30 06:00 [entrez]
PHST- 2017/04/01 00:00 [pubmed]
PHST- 2018/12/13 06:00 [medline]
PST - ppublish
SO  - J Egypt Soc Parasitol. 2017 Apr;47(1):101-105.