PMID- 30159809
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20200225
IS  - 0973-7693 (Electronic)
IS  - 0019-5456 (Linking)
VI  - 86
IP  - 3
DP  - 2019 Mar
TI  - Platelet-Derived Microparticles: A New Index of Monitoring Platelet Activation 
      and Inflammation in Kawasaki Disease.
PG  - 250-255
LID - 10.1007/s12098-018-2765-2 [doi]
AB  - OBJECTIVE: To investigate the dynamic changes of platelet-derived microparticles 
      (PDMP) in Kawasaki disease (KD) and its clinical significance and to study its 
      relationship with intravenous immunoglobulin (IVIG) resistance, inflammatory 
      indicators and aspirin treatment in children with KD. METHODS: Twenty children 
      with KD were enrolled as the experimental group, while 20 age- and gender-matched 
      children with common febrile disease were included in the control group. Blood 
      samples were drawn before and 7-10 d after IVIG infusion and thereafter at 1, 2, 
      and 3 mo after the onset of KD to estimate the PDMP concentrations by enzyme 
      linked immunosorbent assay (ELISA). C-reactive protein (hs-CRP), erythrocyte 
      sedimentation rate (ESR), procalcitonin (PCT), and cytokines [Interleukin-6 
      (IL-6), Tumor necrosis factor-alpha (TNF-alpha), and Soluble interleukin-2 (sIL-2R)] were 
      also measured. RESULTS: The level of PDMP in KD children before IVIG was 
      significantly higher than that in controls (P < 0.0001). The PDMP level in KD 
      children decreased significantly at 7 to 10 d after IVIG (P < 0.0001) and then 
      decreased to the lowest level in the course of 1 to 2 mo. Some children's PDMP 
      level rebounded in the course of 3 mo (P = 0.047). In addition, the mean level of 
      PDMP in IVIG-resistant children was higher than that in IVIG-effective children; 
      however, there was no significant difference between the two groups (P = 0.1945). 
      Furthermore, PDMP was positively correlated with hs-CRP, IL-6, and sIL-2R levels, 
      but no correlation was observed with ESR, PCT, and TNF-alpha levels. CONCLUSIONS: 
      PDMP can be used as an index to monitor inflammation in children at the acute 
      stage of KD. And the duration of platelet activation in KD is individualized.
FAU - Jin, Jing
AU  - Jin J
AD  - Children's Hospital of Nanjing Medical University, Nanjing, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Nanjing Tongren Hospital, School of Medicine Southeast University, Nanjing, 
      China.
FAU - Lu, Yadong
AU  - Lu Y
AD  - Children's Hospital of Nanjing Medical University, Nanjing, China.
FAU - Fan, Zhidan
AU  - Fan Z
AD  - Children's Hospital of Nanjing Medical University, Nanjing, China.
FAU - Huang, Na
AU  - Huang N
AD  - Children's Hospital of Nanjing Medical University, Nanjing, China.
FAU - Ma, Le
AU  - Ma L
AD  - Children's Hospital of Nanjing Medical University, Nanjing, China.
FAU - Yu, Haiguo
AU  - Yu H
AUID- ORCID: 0000-0002-1115-238X
AD  - Children's Hospital of Nanjing Medical University, Nanjing, China. 
      yuhaiguo73@126.com.
LA  - eng
PT  - Journal Article
DEP - 20180830
PL  - India
TA  - Indian J Pediatr
JT  - Indian journal of pediatrics
JID - 0417442
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
CIN - Indian J Pediatr. 2019 Mar;86(3):216-217. PMID: 30741390
MH  - Aspirin/therapeutic use
MH  - Biomarkers/*blood
MH  - *Blood Platelets
MH  - Blood Sedimentation
MH  - C-Reactive Protein/analysis
MH  - *Cell-Derived Microparticles
MH  - Child, Preschool
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous
MH  - Infant
MH  - *Inflammation
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*blood/diagnosis/therapy
MH  - *Platelet Activation
OTO - NOTNLM
OT  - Inflammation
OT  - Kawasaki disease
OT  - Platelet activation
OT  - Platelet-derived microparticle
EDAT- 2018/08/31 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/08/31 06:00
PHST- 2017/12/08 00:00 [received]
PHST- 2018/08/01 00:00 [accepted]
PHST- 2018/08/31 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/08/31 06:00 [entrez]
AID - 10.1007/s12098-018-2765-2 [pii]
AID - 10.1007/s12098-018-2765-2 [doi]
PST - ppublish
SO  - Indian J Pediatr. 2019 Mar;86(3):250-255. doi: 10.1007/s12098-018-2765-2. Epub 
      2018 Aug 30.