PMID- 30159899
OWN - NLM
STAT- MEDLINE
DCOM- 20190320
LR  - 20190320
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 59 Suppl 2
DP  - 2018 Oct
TI  - Neurotrophic factors and status epilepticus.
PG  - 87-91
LID - 10.1111/epi.14501 [doi]
AB  - Because of their strong effects on cell survival and on synaptic function, 
      neurotrophic factors (NTFs) have been hypothesized to be involved in some aspects 
      of status epilepticus (SE) and in its possible consequences. This hypothesis has 
      been explored mainly for 2 NTFs, namely fibroblast growth factor 2 (FGF-2) and 
      brain-derived neurotrophic factor (BDNF). This article focuses on these 2 NTFs. I 
      first summarize their biologic features and then describe existing evidence 
      supporting their implication in SE and its outcomes. Available data support a 
      direct implication of FGF-2 and BDNF in SE and in its consequences. However, 
      these NTFs have been found to exert some contrasting effects, for example, to 
      favor seizures but protect from cell damage. A better understanding of the 
      mechanisms of FGF-2 and BDNF biosynthesis and signaling will be therefore 
      instrumental for the development of therapeutic strategies that are not 
      compromised by paradoxical side effects.
CI  - Wiley Periodicals, Inc. (c) 2018 International League Against Epilepsy.
FAU - Simonato, Michele
AU  - Simonato M
AD  - Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
AD  - Division of Neuroscience, University Vita-Salute San Raffaele, Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180829
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Fibroblast Growth Factor 2/metabolism
MH  - Humans
MH  - Nerve Growth Factors/*metabolism
MH  - Seizures/drug therapy/*metabolism
MH  - Signal Transduction/physiology
MH  - Status Epilepticus/drug therapy/*metabolism
OTO - NOTNLM
OT  - animal models
OT  - brain-derived neurotrophic factor
OT  - fibroblast growth factor 2
OT  - neurotrophic factors
OT  - status epilepticus
EDAT- 2018/08/31 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/08/31 06:00
PHST- 2017/10/23 00:00 [accepted]
PHST- 2018/08/31 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/08/31 06:00 [entrez]
AID - 10.1111/epi.14501 [doi]
PST - ppublish
SO  - Epilepsia. 2018 Oct;59 Suppl 2:87-91. doi: 10.1111/epi.14501. Epub 2018 Aug 29.