PMID- 30160617
OWN - NLM
STAT- MEDLINE
DCOM- 20200401
LR  - 20221207
IS  - 1541-1087 (Electronic)
IS  - 0731-5724 (Linking)
VI  - 38
IP  - 1
DP  - 2019 Jan
TI  - Association Between Magnesium Status, Dietary Magnesium Intake, and Metabolic 
      Control in Patients with Type 2 Diabetes Mellitus.
PG  - 31-39
LID - 10.1080/07315724.2018.1476194 [doi]
AB  - BACKGROUND: Hypomagnesemia could worsen glycemic control by impairing insulin 
      release and promoting insulin resistance. On the contrary, type 2 diabetes 
      mellitus (T2DM) may induce and/or exacerbate low serum magnesium levels, and this 
      could, in turn, worsen glycemic control of diabetes. OBJECTIVE: The aim of this 
      study was to investigate the relationship between serum magnesium level, dietary 
      magnesium intake, and metabolic control parameters in patients with T2DM. 
      METHODS: The study included 119 patients with T2DM (26 male, 93 female; mean age 
      54.7 +/- 8.4 years). Serum magnesium level was measured by spectrophotometric 
      method. Magnesium intake was assessed by food frequency questionnaire. 
      Anthropometric measurements were taken. The General Linear Model procedure was 
      applied to determine the relationship of serum magnesium with quantitative 
      variables. RESULTS: Of the 119 patients, 23.5% of the patients had inadequate 
      magnesium intake (lower than 67% of the recommended daily allowance), and 18.5% 
      had hypomagnesemia. In patients with hypomagnesemia (< 0.75 mmol/l), serum levels 
      of fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and serum 
      glycosylated hemoglobin (HbA1c) were higher compared to patients with 
      normomagnesemia. FPG levels were significantly higher in patients with 
      hypomagnesemia in Model 1 (179.0 +/- 64.9 vs. 148.7 +/- 52.0 mg/dl, p = 0.009) but 
      the significance disappeared in other models. PPG levels were significantly 
      higher in patients with hypomagnesemia in all models (287.9 +/- 108.4 vs. 
      226.8 +/- 89.4 mg/dl, p = 0.006 for Model 1, p = 0.027 for Model 2, p = 0.016 for 
      Model 3). Serum HbA1c levels were significantly higher in patients with 
      hypomagnesemia, and this significance proceeded (8.0 +/- 1.9% vs. 6.5 +/- 1.2%, 
      p = 0.000 for all models). Body fat mass was significantly higher in patients 
      with hypomagnesemia as compared to patients with normomagnesemia in model 3 
      (35.4 +/- 9.4 kg, 34.6 +/- 10.2 kg; p = 0.034). Dietary magnesium intake was not 
      significantly associated with either metabolic parameters or anthropometric 
      measurements. CONCLUSION: Hypomagnesemia in T2DM is directly associated with poor 
      metabolic control. Clinical assessment should, therefore, focus on augmentation 
      of magnesium status and adequate magnesium intake in patients with T2DM.
FAU - Ozcaliskan Ilkay, Hatice
AU  - Ozcaliskan Ilkay H
AD  - a Department of Nutrition and Dietetics , Erciyes University , Melikgazi, Kayseri 
      , Turkey.
FAU - Sahin, Habibe
AU  - Sahin H
AD  - a Department of Nutrition and Dietetics , Erciyes University , Melikgazi, Kayseri 
      , Turkey.
FAU - Tanriverdi, Fatih
AU  - Tanriverdi F
AD  - b Department of Endocrinology and Metabolism , Erciyes University , Melikgazi, 
      Kayseri , Turkey.
FAU - Samur, Gulhan
AU  - Samur G
AD  - c Department of Nutrition and Dietetics , Hacettepe University , Sihhiye, Ankara 
      , Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180830
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Body Composition/physiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - *Diet
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Magnesium/administration & dosage/*blood
MH  - Magnesium Deficiency/blood/*complications
MH  - Male
MH  - Middle Aged
MH  - Nutritional Status
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - dietary magnesium intake
OT  - magnesium status
OT  - metabolic control
EDAT- 2018/08/31 06:00
MHDA- 2020/04/02 06:00
CRDT- 2018/08/31 06:00
PHST- 2018/08/31 06:00 [pubmed]
PHST- 2020/04/02 06:00 [medline]
PHST- 2018/08/31 06:00 [entrez]
AID - 10.1080/07315724.2018.1476194 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 2019 Jan;38(1):31-39. doi: 10.1080/07315724.2018.1476194. Epub 
      2018 Aug 30.