PMID- 30160781
OWN - NLM
STAT- MEDLINE
DCOM- 20191210
LR  - 20191217
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 119
IP  - 11
DP  - 2018 Nov
TI  - Osteocyte-intrinsic mTORC1 signaling restrains trabecular bone accrual in mice.
PG  - 8743-8749
LID - 10.1002/jcb.27470 [doi]
AB  - Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling plays 
      important physiological roles in bone homeostasis by regulating multiple steps of 
      osteoblast differentiation as well as its activity. However, its potential role 
      in osteocytes has not been explored. In this study, we deleted Raptor, a specific 
      and essential component of mTORC1, in osteocytes using Dmp1-Cre. Deletion of 
      Raptor in osteocytes did not affect bone development and growth, but caused 
      compartment-specific effects on bone mass. Osteocyte-specific deletion of Raptor 
      had no obvious effect on cortical bone compartments, but led to increased 
      trabecular bone mass. Mechanistically, Raptor deletion resulted in decreased bone 
      resorption without altering bone formation activity. Thus, our study revealed an 
      unexpected role of osteocyte-intrinsic mTORC1 signaling in limiting trabecular 
      bone mass, suggesting that osteocyte-specific inhibition of mTORC1 may be used as 
      a novel approach to treatment of osteoporosis.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Liu, Qingbai
AU  - Liu Q
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
AD  - Department of Orthopedics, Lianshui County People's Hospital, Huaian, China.
FAU - Liu, Cunchang
AU  - Liu C
AD  - Orthopedic Institute, Medical College, Soochow University, Suzhou, China.
FAU - Yang, Yanjun
AU  - Yang Y
AD  - Orthopedic Institute, Medical College, Soochow University, Suzhou, China.
FAU - Yang, Huilin
AU  - Yang H
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
AD  - Orthopedic Institute, Medical College, Soochow University, Suzhou, China.
FAU - Chen, Jianquan
AU  - Chen J
AUID- ORCID: 0000-0002-0468-6287
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
AD  - Orthopedic Institute, Medical College, Soochow University, Suzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180830
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Regulatory-Associated Protein of mTOR)
RN  - 0 (Rptor protein, mouse)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
SB  - IM
MH  - Animals
MH  - Bone Density/*physiology
MH  - Bone Development/physiology
MH  - Bone Resorption/metabolism
MH  - Cancellous Bone/*metabolism
MH  - Cortical Bone/metabolism
MH  - Gene Knockout Techniques
MH  - Mechanistic Target of Rapamycin Complex 1/*metabolism
MH  - Mice
MH  - Osteoclasts/metabolism
MH  - Osteocytes/*metabolism
MH  - Osteoporosis/metabolism
MH  - Regulatory-Associated Protein of mTOR/*genetics/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - bone resorption
OT  - mechanistic target of rapamycin (mTOR) complex 1 (mTORC1)
OT  - osteocytes
OT  - raptor
OT  - trabecular bone
EDAT- 2018/08/31 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/08/31 06:00
PHST- 2018/04/19 00:00 [received]
PHST- 2018/07/18 00:00 [accepted]
PHST- 2018/08/31 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/08/31 06:00 [entrez]
AID - 10.1002/jcb.27470 [doi]
PST - ppublish
SO  - J Cell Biochem. 2018 Nov;119(11):8743-8749. doi: 10.1002/jcb.27470. Epub 2018 Aug 
      30.