PMID- 30166919
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1319-0164 (Print)
IS  - 2213-7475 (Electronic)
IS  - 1319-0164 (Linking)
VI  - 26
IP  - 2
DP  - 2018 Feb
TI  - Roles of some antioxidants in modulation of cardiac myopathy induced by sodium 
      nitrite via down-regulation of mRNA expression of NF-kappaB, Bax, and flt-1 and 
      suppressing DNA damage.
PG  - 217-223
LID - 10.1016/j.jsps.2017.12.008 [doi]
AB  - The underlying pathology of cardiac damage involves various molecular and 
      signaling pathways. Therefore, this study aimed to explore the role of Quercetin 
      (Querc), alone or in combination with Melatonin (Melat) against cardiac damage 
      induced by sodium nitrite (Sod nit), as well as to elucidate different signaling 
      pathways. Querc and Melat were injected intraperitoneally (i.p.), followed by 
      induction of hypoxia in rats by using a single dose of Sod nit (60 mg/kg, s.c.). 
      Treatment with Sod nit significantly decreased hemoglobin (Hb) levels in blood. 
      Pretreatment of hypoxic rats with Querc and/or Melat elevated the declined Hb 
      concentration. The forementioned antioxidants also successfully ameliorated the 
      alteration of heat shock protein 70 (HSP-70) and markers of cardiac injury, 
      including troponin T (Trop. T), creatine kinase-MB (CK-MB), tumor necrosis 
      factor-alpha (TNF alpha), and C-reactive protein (CRP) in the rats serum. Furthermore, 
      RT-PCR revealed that these antioxidants successfully modulated mRNA expression of 
      NF-kappaB, Bax, Bcl-2, and flt-1. They also regulated vascular endothelial growth 
      factor (VEGF), the apoptosis marker caspase 3, and oxidative DNA damage in 
      cardiac tissue, compared to Sod nit-intoxicated rats. The present biochemical 
      results are reinforced by histopathological examination. IN CONCLUSION: The 
      results reflected that treatment with Querc in combination with Melat was most 
      effective in improving Sod nit-toxicity induced cardiac damage, thus confirming 
      the promising role of this combination as an effective treatment for cardiac 
      damage induced by other cardio-toxic agents.
FAU - Fadda, Laila Mohamed
AU  - Fadda LM
AD  - Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Attia, Hala A
AU  - Attia HA
AD  - Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi 
      Arabia.
AD  - Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 
      Egypt.
FAU - Al-Rasheed, Nouf Mohamed
AU  - Al-Rasheed NM
AD  - Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Ali, Hanaa Mahmoud
AU  - Ali HM
AD  - Department of Genetics and Cytology, National Research Center, Dokki, Egypt.
AD  - Common First Year Deanship, King Saud University, Riyadh, Saudi Arabia.
FAU - Al-Rasheed, Nawal Mohamed
AU  - Al-Rasheed NM
AD  - Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi 
      Arabia.
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint 
      Abdulrahman University, Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20171211
PL  - Saudi Arabia
TA  - Saudi Pharm J
JT  - Saudi pharmaceutical journal : SPJ : the official publication of the Saudi 
      Pharmaceutical Society
JID - 9705695
PMC - PMC6111199
OTO - NOTNLM
OT  - Cardiac tissue
OT  - Comet assay
OT  - Hypoxia
OT  - Melatonin, Quercetin
EDAT- 2018/09/01 06:00
MHDA- 2018/09/01 06:01
PMCR- 2017/12/11
CRDT- 2018/09/01 06:00
PHST- 2017/11/18 00:00 [received]
PHST- 2017/12/10 00:00 [accepted]
PHST- 2018/09/01 06:00 [entrez]
PHST- 2018/09/01 06:00 [pubmed]
PHST- 2018/09/01 06:01 [medline]
PHST- 2017/12/11 00:00 [pmc-release]
AID - S1319-0164(17)30216-5 [pii]
AID - 10.1016/j.jsps.2017.12.008 [doi]
PST - ppublish
SO  - Saudi Pharm J. 2018 Feb;26(2):217-223. doi: 10.1016/j.jsps.2017.12.008. Epub 2017 
      Dec 11.