PMID- 30166978
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 9
DP  - 2018
TI  - Relationship Between Vitamin D Status and Vitamin D Receptor Gene Polymorphisms 
      With Markers of Metabolic Syndrome Among Adults.
PG  - 448
LID - 10.3389/fendo.2018.00448 [doi]
LID - 448
AB  - Introduction: Recent studies have demonstrated that vitamin D deficiency 
      contributes to the development of metabolic disorders, including obesity and type 
      2 diabetes mellitus (T2DM). Several vitamin D receptor (VDR) gene polymorphisms 
      had been described to play a role in these conditions since vitamin D receptors 
      were found in many tissues. The aim of this study was to assess the relationship 
      between vitamin D status and VDR gene polymorphisms with metabolic syndrome (MS) 
      parameters in Russian middle-aged women. Materials and Methods: A total of 697 
      women aged between 30 to 55 years were included in this cross-sectional study. 
      Serum 25-hydroxyvitamin D (25(OH)D) level and four VDR gene polymorphisms 
      rs1544410 (BsmI), rs7975232 (ApaI), rs731236 (TaqI), and rs2228570 (FokI) were 
      measured. We applied the International Diabetes Federation (IDF) criteria to 
      identify subjects with MS. Results: 9.3% of subjects had normal vitamin D level, 
      while 90.7% were insufficient or deficient. Abdominal obesity (AO) was seen in 
      75.5%, impaired glucose tolerance (IGT) or T2DM was observed in 33.3%, reduced 
      high-density lipoprotein cholesterol (HDL-C) level in 32.2% and 
      hypertriglyceridemia in 23.4%. Serum 25(OH)D level in women with or without MS 
      did not differ (48.6 +/- 1.8 and 51.1 +/- 1.5 nmol/l, p > 0.05). Subjects with 
      vitamin D deficiency showed an increased risk of AO [CI 95% 2.23; 1.15-4.30] and 
      low HDL-C [CI95% 2.60; 1.04-6.49] compared to subjects with normal 25(OH)D level. 
      IGT and T2DM risk was increased only when 25(OH)D concentration was less than 
      39.0 nmol/l [CI 95% 7.17; 2.99-17.7], but risk of MS did not differ in normal 
      vitamin D status subjects and insufficient/deficient ones (p > 0.05). T allele 
      carriers (A) of rs7975232 had higher total cholesterol and low-density 
      lipoprotein cholesterol levels compared with the GG (aa) genotypes. Similarly, GG 
      (BB) genotype carriers of rs1544410 had higher triglyceride levels than subjects 
      with A (b) allele carriers. However VDR gene polymorphisms did not seem to be 
      associated with an increased risk of MS. Conclusions: Vitamin D deficiency, 
      rs7975232, and rs1544410 VDR gene variants are associated with MS parameters in 
      Russian middle-aged women.
FAU - Karonova, Tatiana
AU  - Karonova T
AD  - Institute of Endocrinology, Almazov National Medical Research Centre, St. 
      Petersburg, Russia.
AD  - Internal Medicine Department, Pavlov First Saint Petersburg State Medical 
      University, St. Petersburg, Russia.
FAU - Grineva, Elena
AU  - Grineva E
AD  - Institute of Endocrinology, Almazov National Medical Research Centre, St. 
      Petersburg, Russia.
AD  - Internal Medicine Department, Pavlov First Saint Petersburg State Medical 
      University, St. Petersburg, Russia.
FAU - Belyaeva, Olga
AU  - Belyaeva O
AD  - Internal Medicine Department, Pavlov First Saint Petersburg State Medical 
      University, St. Petersburg, Russia.
FAU - Bystrova, Anna
AU  - Bystrova A
AD  - Institute of Endocrinology, Almazov National Medical Research Centre, St. 
      Petersburg, Russia.
AD  - Internal Medicine Department, Pavlov First Saint Petersburg State Medical 
      University, St. Petersburg, Russia.
FAU - Jude, Edward B
AU  - Jude EB
AD  - Tameside Hospital NHS Foundation Trust, Ashton Under Lyne, United Kingdom.
FAU - Andreeva, Alena
AU  - Andreeva A
AD  - Institute of Endocrinology, Almazov National Medical Research Centre, St. 
      Petersburg, Russia.
FAU - Kostareva, Anna
AU  - Kostareva A
AD  - Institute of Molecular Biology and Genetics, Almazov National Medical Research 
      Centre, St. Petersburg, Russia.
FAU - Pludowski, Pawel
AU  - Pludowski P
AD  - Department of Biochemistry, Radioimmunology and Experimental Medicine, The 
      Children's Memorial Health Institute, Warsaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20180816
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6106967
OTO - NOTNLM
OT  - VDR gene polymorphisms
OT  - diabetes
OT  - dyslipidemia
OT  - metabolic syndrome
OT  - obesity
EDAT- 2018/09/01 06:00
MHDA- 2018/09/01 06:01
PMCR- 2018/01/01
CRDT- 2018/09/01 06:00
PHST- 2018/03/28 00:00 [received]
PHST- 2018/07/20 00:00 [accepted]
PHST- 2018/09/01 06:00 [entrez]
PHST- 2018/09/01 06:00 [pubmed]
PHST- 2018/09/01 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2018.00448 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2018 Aug 16;9:448. doi: 10.3389/fendo.2018.00448. 
      eCollection 2018.