PMID- 30167004 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230928 IS - 1880-4276 (Print) IS - 1883-2148 (Electronic) IS - 1880-4276 (Linking) VI - 34 IP - 4 DP - 2018 Aug TI - Ventricular arrhythmias in nonischemic cardiomyopathy. PG - 336-346 LID - 10.1002/joa3.12028 [doi] AB - Nonischemic cardiomyopathies (NICMs) are composed of variable disease entities, including primary and secondary cardiomyopathies. Determining the etiology of NICM provides pivotal roles of not only the understanding of the individual pathogenesis, but also the clinical management, such as risk stratification, pharmacological treatment, and intervention therapies. Despite the diverse causes of NICM, these cases mostly require clinical attention owing to progressive myocardial injury, resulting in ventricular dysfunction and heart failure. The interaction between the diseased ventricular substrates and systemic/neurophysiological factors contributes to the cornerstones responsible for ventricular arrhythmogenesis and sudden cardiac death (SCD). Prevention of SCD and diminishing ventricular tachyarrhythmias are the important mainstays for the management of NICM patients. Given the understanding of the abnormal ventricular substrates and advancement of navigation systems, radiofrequency catheter ablation (RFCA) has become an adjunctive or alternative strategy for NICM patients who experience drug-refractory ventricular tachycardias (VTs). Successful ablation can frequently be achieved at the expense of an epicardial intervention. A recent study has proven the survival benefits for NICM patients who are free from recurrent VTs after a successful RFCA, regardless of the New York Heart Association (NYHA) functional class status or left ventricular ejection fraction. Additionally, recent evidence has highlighted the better delineation of a diseased myocardium through the incorporation of cardiovascular magnetic resonance imaging (CMRI) and 3D mapping systems, which can facilitate the identification of critical ventricular arrhythmogenic substrates in NICM patients. FAU - Chung, Fa-Po AU - Chung FP AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Lin, Chin-Yu AU - Lin CY AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. AD - Department of Medicine Taipei Veterans General Hospital Taipei Yilan County Taiwan. FAU - Lin, Yenn-Jiang AU - Lin YJ AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Chang, Shih-Lin AU - Chang SL AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Lo, Li-Wei AU - Lo LW AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Hu, Yu-Feng AU - Hu YF AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Tuan, Ta-Chuan AU - Tuan TC AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Chao, Tze-Fan AU - Chao TF AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Liao, Jo-Nan AU - Liao JN AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Chang, Yao-Ting AU - Chang YT AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Chang, Ting-Yung AU - Chang TY AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. FAU - Lin, Chung-Hsing AU - Lin CH AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Department of Medicine Taipei Veterans General Hospital Taipei Yilan County Taiwan. FAU - Te, Abigail Louise D AU - Te ALD AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. FAU - Yamada, Shinya AU - Yamada S AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. FAU - Chen, Shih-Ann AU - Chen SA AD - Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan. AD - Institute of Clinical Medicine Department of Medicine National Yang-Ming University School of Medicine Taipei Taiwan. LA - eng PT - Journal Article DEP - 20180307 PL - Japan TA - J Arrhythm JT - Journal of arrhythmia JID - 101263026 PMC - PMC6111466 OTO - NOTNLM OT - arrhythmogenic substrate OT - cardiovascular magnetic resonance imaging OT - catheter ablation OT - implantable cardioverter-defibrillator OT - sudden cardiac death EDAT- 2018/09/01 06:00 MHDA- 2018/09/01 06:01 PMCR- 2018/03/07 CRDT- 2018/09/01 06:00 PHST- 2017/06/05 00:00 [received] PHST- 2017/08/30 00:00 [accepted] PHST- 2018/09/01 06:00 [entrez] PHST- 2018/09/01 06:00 [pubmed] PHST- 2018/09/01 06:01 [medline] PHST- 2018/03/07 00:00 [pmc-release] AID - JOA312028 [pii] AID - 10.1002/joa3.12028 [doi] PST - epublish SO - J Arrhythm. 2018 Mar 7;34(4):336-346. doi: 10.1002/joa3.12028. eCollection 2018 Aug.