PMID- 30168252
OWN - NLM
STAT- MEDLINE
DCOM- 20190130
LR  - 20190130
IS  - 1447-0594 (Electronic)
IS  - 1447-0594 (Linking)
VI  - 18
IP  - 10
DP  - 2018 Oct
TI  - Clinical features and outcomes in patients with elderly-onset anti-neutrophil 
      cytoplasmic antibody-associated vasculitis.
PG  - 1453-1457
LID - 10.1111/ggi.13511 [doi]
AB  - AIM: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is commonly 
      seen in older patients. The present study intended to clarify whether 
      elderly-onset AAV (at age >/=75 years) shows any specific clinical features and 
      outcomes in Japanese patients. METHODS: This study was a retrospective cohort 
      study. A total of 36 AAV patients who were initially treated at the Department of 
      Rheumatology, Fukushima Medical University Hospital (Fukushima, Japan) between 
      2004 and 2016 were included. AAV patients were divided into an elderly group 
      (>/=75 years) and a younger group (<75 years), and their clinical records were 
      reviewed. RESULTS: Elderly AAV patients showed similar clinical features to 
      younger AAV patients, except that they were more often women, weighed less, had 
      an increased frequency of kidney involvement and had lower serum ferritin levels. 
      Kaplan-Meier analyses showed significantly lower 1-year survival in elderly AAV 
      (P =0.008) as well as AAV patients enrolled not receiving additional 
      immunosuppressive treatment (P =0.023). The cause of death was disease 
      progression itself or infection. CONCLUSIONS: The clinical features of AAV are 
      similar between elderly and younger patients, except for increased kidney 
      involvement and lower serum ferritin levels. Proper monitoring of the disease and 
      adverse events, and providing conventional immunosuppressive therapy is suggested 
      to avoid a poor outcome, especially in elderly AAV patients. Geriatr Gerontol Int 
      2018; 18: 1453-1457.
CI  - (c) 2018 Japan Geriatrics Society.
FAU - Sato, Shuzo
AU  - Sato S
AUID- ORCID: 0000-0002-8110-8261
AD  - Department of Rheumatology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Yashiro, Makiko
AU  - Yashiro M
AD  - Department of Rheumatology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Matsuoka, Naoki
AU  - Matsuoka N
AD  - Department of Rheumatology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Asano, Tomoyuki
AU  - Asano T
AD  - Department of Rheumatology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Kobayashi, Hiroko
AU  - Kobayashi H
AD  - Department of Rheumatology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Watanabe, Hiroshi
AU  - Watanabe H
AD  - Department of Rheumatology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Migita, Kiyoshi
AU  - Migita K
AD  - Department of Rheumatology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180830
PL  - Japan
TA  - Geriatr Gerontol Int
JT  - Geriatrics & gerontology international
JID - 101135738
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*diagnosis/drug 
      therapy/*mortality
MH  - *Cause of Death
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Hospitals, University
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Japan
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Survival Rate
OTO - NOTNLM
OT  - anti-neutrophil cytoplasmic antibody-associated vasculitis
OT  - clinical features
OT  - elderly onset
OT  - ferritin
OT  - outcome
EDAT- 2018/09/01 06:00
MHDA- 2019/01/31 06:00
CRDT- 2018/09/01 06:00
PHST- 2017/12/13 00:00 [received]
PHST- 2018/07/01 00:00 [revised]
PHST- 2018/07/14 00:00 [accepted]
PHST- 2018/09/01 06:00 [pubmed]
PHST- 2019/01/31 06:00 [medline]
PHST- 2018/09/01 06:00 [entrez]
AID - 10.1111/ggi.13511 [doi]
PST - ppublish
SO  - Geriatr Gerontol Int. 2018 Oct;18(10):1453-1457. doi: 10.1111/ggi.13511. Epub 
      2018 Aug 30.