PMID- 30169884
OWN - NLM
STAT- MEDLINE
DCOM- 20200629
LR  - 20210929
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 45
IP  - 4
DP  - 2019 Jun 18
TI  - Salience-Default Mode Functional Network Connectivity Linked to Positive and 
      Negative Symptoms of Schizophrenia.
PG  - 892-901
LID - 10.1093/schbul/sby112 [doi]
AB  - Schizophrenia is a complex, debilitating mental disorder characterized by 
      wide-ranging symptoms including delusions, hallucinations (so-called positive 
      symptoms), and impaired motor and speech/language production (so-called negative 
      symptoms). Salience-monitoring theorists propose that abnormal functional 
      communication between the salience network (SN) and default mode network (DMN) 
      begets positive and negative symptoms of schizophrenia, yet prior studies have 
      predominately reported links between disrupted SN/DMN functional communication 
      and positive symptoms. It remains unclear whether disrupted SN/DMN functional 
      communication explains (1) solely positive symptoms or (2) both positive and 
      negative symptoms of schizophrenia. To address this question, we incorporate 
      time-lag-shifted functional network connectivity (FNC) analyses that explored 
      coherence of the resting-state functional magnetic resonance imaging signal of 3 
      networks (anterior DMN, posterior DMN, and SN) with fixed time lags introduced 
      between network time series (1 TR = 2 s; 2 TR = 4 s). Multivariate linear 
      regression analysis revealed that severity of disordered thought and attentional 
      deficits were negatively associated with 2 TR-shifted FNC between anterior DMN 
      and posterior DMN. Meanwhile, severity of flat affect and bizarre behavior were 
      positively associated with 1 TR-shifted FNC between anterior DMN and SN. These 
      results provide support favoring the hypothesis that lagged SN/DMN functional 
      communication is associated with both positive and negative symptoms of 
      schizophrenia.
CI  - (c) The Author(s) 2018. Published by Oxford University Press on behalf of the 
      Maryland Psychiatric Research Center. All rights reserved. For permissions, 
      please email: journals.permissions@oup.com.
FAU - Hare, Stephanie M
AU  - Hare SM
AD  - Neuroscience Institute, Georgia State University, Atlanta, GA.
FAU - Ford, Judith M
AU  - Ford JM
AD  - Psychiatry Service, San Francisco VA Medical Center, San Francisco, CA.
AD  - Department of Psychiatry, University of California, San Francisco, CA.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - Psychiatry Service, San Francisco VA Medical Center, San Francisco, CA.
AD  - Department of Psychiatry, University of California, San Francisco, CA.
FAU - Damaraju, Eswar
AU  - Damaraju E
AD  - The Mind Research Network, Albuquerque, NM.
FAU - Bustillo, Juan
AU  - Bustillo J
AD  - Department of Psychiatry and Behavioral Sciences, The University of New Mexico, 
      Albuquerque, NM.
FAU - Belger, Aysenil
AU  - Belger A
AD  - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC.
FAU - Lee, Hyo Jong
AU  - Lee HJ
AD  - Division of Computer Science and Engineering, CAIIT, Chonbuk National University, 
      Jeonju, Republic of Korea.
FAU - Mueller, Bryon A
AU  - Mueller BA
AD  - Department of Psychiatry, University of Minnesota, Minneapolis, MN.
FAU - Lim, Kelvin O
AU  - Lim KO
AD  - Department of Psychiatry, University of Minnesota, Minneapolis, MN.
AD  - Geriatric Research, Education and Clinical Center (GRECC), Minneapolis VA Health 
      Care System, Minneapolis, MN.
FAU - Brown, Gregory G
AU  - Brown GG
AD  - Department of Psychiatry, School of Medicine, University of California San Diego, 
      San Diego, CA.
FAU - Preda, Adrian
AU  - Preda A
AD  - Department of Psychiatry and Human Behavior, University of California, Irvine, 
      Irvine, CA.
FAU - van Erp, Theo G M
AU  - van Erp TGM
AD  - Department of Psychiatry and Human Behavior, University of California, Irvine, 
      Irvine, CA.
FAU - Potkin, Steven G
AU  - Potkin SG
AD  - Department of Psychiatry and Human Behavior, University of California, Irvine, 
      Irvine, CA.
FAU - Calhoun, Vince D
AU  - Calhoun VD
AD  - The Mind Research Network, Albuquerque, NM.
AD  - Department of Electrical and Computer Engineering, University of New Mexico, 
      Albuquerque, NM.
FAU - Turner, Jessica A
AU  - Turner JA
AD  - Neuroscience Institute, Georgia State University, Atlanta, GA.
AD  - The Mind Research Network, Albuquerque, NM.
AD  - Department of Psychology, Georgia State University, Atlanta, GA.
LA  - eng
GR  - R01 MH094524/MH/NIMH NIH HHS/United States
GR  - R01 EB006841/EB/NIBIB NIH HHS/United States
GR  - U24 RR021992/RR/NCRR NIH HHS/United States
GR  - R01 EB020407/EB/NIBIB NIH HHS/United States
GR  - P20 GM103472/GM/NIGMS NIH HHS/United States
GR  - R01 MH118695/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
EIN - Schizophr Bull. 2019 Oct 24;45(6):1382. PMID: 30272217
MH  - Adult
MH  - *Connectome
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/diagnostic imaging/*physiopathology
MH  - Schizophrenia/diagnostic imaging/*physiopathology
PMC - PMC6581131
OTO - NOTNLM
OT  - ICA
OT  - default mode network
OT  - negative symptoms
OT  - positive symptoms
OT  - resting-state fMRI
OT  - salience network
EDAT- 2018/09/01 06:00
MHDA- 2020/07/01 06:00
PMCR- 2020/06/18
CRDT- 2018/09/01 06:00
PHST- 2018/09/01 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PHST- 2018/09/01 06:00 [entrez]
PHST- 2020/06/18 00:00 [pmc-release]
AID - 5087933 [pii]
AID - sby112 [pii]
AID - 10.1093/schbul/sby112 [doi]
PST - ppublish
SO  - Schizophr Bull. 2019 Jun 18;45(4):892-901. doi: 10.1093/schbul/sby112.