PMID- 30170398 OWN - NLM STAT- MEDLINE DCOM- 20180907 LR - 20221005 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 97 IP - 35 DP - 2018 Aug TI - Acupuncture for premature ejaculation: Protocol for a systematic review. PG - e11980 LID - 10.1097/MD.0000000000011980 [doi] LID - e11980 AB - BACKGROUND: Premature ejaculation is a common sexual dysfunction disease in adult males. It can be divided into primary and secondary premature ejaculation. Acupuncture is widely used in the treatment of premature ejaculation in China. There are many clinical trials confirmed that acupuncture can prolong the ejaculation latency in the vagina. We aim to use a meta-analysis to evaluate the efficacy and safety of acupuncture for premature ejaculation. METHOD: We will systematically search all randomized controlled trials (RCTs) by electronic and manual search, until June 31, 2018. Electronic retrieval of the database includes Medline, EMBASE, the Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, the Cochrane Library, the Chinese BioMedical Literature Database, the China National Knowledge Infrastructure (CNKI), the China Science and Technology Journal database (VIP), and the Wanfang database. Manual search will retrieve gray literature, including unpublished conference articles. The primary outcomes include the Intravaginal Ejaculatory Latency Time (IELT). At the same time, Premature Ejaculation Diagnostic Tool (PEDT), Arabic index of Premature Ejaculation (AIPE), Index of Premature Ejaculation (IPE) will be the secondary outcomes. Two reviewers will independently read the articles, extract the data information, and give the assessment of risk of bias. Data analysis will be used the special software like RevMan (version 5.3) and EndNote X7. ETHICS AND DISSEMINATION: This systematic review will evaluate the efficacy and safety of acupuncture for premature ejaculation. This review does not require ethical approval and will be reported in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: PROSPERO CRD42018092783. FAU - Zhao, Qi AU - Zhao Q AD - Graduate School of Beijing University of Chinese Medicine Department of Andrology, Dongzhimen Hospital, Beijing, China. FAU - Dai, Hengheng AU - Dai H FAU - Gong, Xihao AU - Gong X FAU - Wang, Lu AU - Wang L FAU - Cao, Minran AU - Cao M FAU - Li, Haisong AU - Li H FAU - Wang, Bin AU - Wang B LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Acupuncture Therapy/*methods MH - Adult MH - Clinical Protocols MH - Humans MH - Male MH - Premature Ejaculation/*therapy MH - Randomized Controlled Trials as Topic MH - Systematic Reviews as Topic MH - Treatment Outcome PMC - PMC6392721 COIS- The authors have no conflicts of interest in this work. EDAT- 2018/09/02 06:00 MHDA- 2018/09/08 06:00 PMCR- 2018/08/21 CRDT- 2018/09/02 06:00 PHST- 2018/09/02 06:00 [entrez] PHST- 2018/09/02 06:00 [pubmed] PHST- 2018/09/08 06:00 [medline] PHST- 2018/08/21 00:00 [pmc-release] AID - 00005792-201808310-00030 [pii] AID - MD-D-18-05174 [pii] AID - 10.1097/MD.0000000000011980 [doi] PST - ppublish SO - Medicine (Baltimore). 2018 Aug;97(35):e11980. doi: 10.1097/MD.0000000000011980.