PMID- 30170548
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20230928
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 19
IP  - 1
DP  - 2018 Aug 31
TI  - Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine.
PG  - 156
LID - 10.1186/s12881-018-0668-8 [doi]
LID - 156
AB  - BACKGROUND: Genetic and environmental factors play a crucial role in the 
      development of type 2 diabetes mellitus (T2DM) and obesity. This study aimed to 
      investigate the association of the fat-mass and obesity-associated gene (FTO) 
      rs9939609 variant with T2DM and body mass index (BMI) among Palestinian 
      population. METHODS: A total of 399 subjects were recruited, of whom 281 were 
      type 2 diabetic patients and 118 normoglycemic subjects. All of them were 
      unrelated, aged > 40 years and recruited within the period 2016-2017. The A 
      allele of FTO rs9939609 was identified by PCR-RFLP. RESULTS: Significant 
      association of the minor allele A of FTO rs9939609 and T2DM risk was observed 
      with an allelic odd ratio of 1.92 (95% CI [1.09-3.29], p = 0.02) adjusted for age 
      and gender, this association partly attenuated when adjusted for BMI with OR of 
      1.84, (95%CI [1.04-3.05], p = 0.03). Stratified data by glycemic status across 
      FTO genotypes showed that A allele was marginally associated with increased BMI 
      among diabetic group (p = 0.057) but not in control group (p = 0.7). Moreover, no 
      significant association was observed between FTO genotypes and covariates of age, 
      gender, T2DM complications or any tested metabolic trait in both diabetic and 
      nondiabetic individuals (p > 0.05). CONCLUSIONS: The variant rs9939609 of the FTO 
      gene was associated with T2DM in Palestine. This is the first study conducted on 
      this gene in the Palestinian population and provides valuable information for 
      comparison with other ethnic groups. Further analysis with larger sample size is 
      required to elucidate the role of this variant on the predisposition to increased 
      BMI in Palestinians.
FAU - Sabarneh, Anas
AU  - Sabarneh A
AD  - Biochemistry and Molecular Biology Department, Faculty of Medicine, Al-Quds 
      University, Abu Dis-East Jerusalem, Palestine.
FAU - Ereqat, Suheir
AU  - Ereqat S
AUID- ORCID: 0000-0003-3706-5732
AD  - Biochemistry and Molecular Biology Department, Faculty of Medicine, Al-Quds 
      University, Abu Dis-East Jerusalem, Palestine. sereqat@staff.alquds.edu.
AD  - Al-Quds Nutrition and Health Research Institute - Faculty of Medicine, Al-Quds 
      University-Palestine, Abu Dis-Jerusalem, Palestine. sereqat@staff.alquds.edu.
FAU - Cauchi, Stephane
AU  - Cauchi S
AD  - CNRS, UMR8204, Lille, France.
AD  - INSERM, U1019, Lille, France.
AD  - Universite de Lille, Lille, France.
AD  - Institut Pasteur de Lille, Centre d'Infection et d'Immunite de Lille, Lille, 
      France.
FAU - AbuShamma, Omar
AU  - AbuShamma O
AD  - Biochemistry and Molecular Biology Department, Faculty of Medicine, Al-Quds 
      University, Abu Dis-East Jerusalem, Palestine.
FAU - Abdelhafez, Mohammad
AU  - Abdelhafez M
AD  - Biochemistry and Molecular Biology Department, Faculty of Medicine, Al-Quds 
      University, Abu Dis-East Jerusalem, Palestine.
FAU - Ibrahim, Murad
AU  - Ibrahim M
AD  - Microbiology and immunology Department-Faculty of Medicine, Al-Quds 
      University-Palestine, Abu Dis-East Jerusalem, Palestine.
FAU - Nasereddin, Abdelmajeed
AU  - Nasereddin A
AD  - Al-Quds Nutrition and Health Research Institute - Faculty of Medicine, Al-Quds 
      University-Palestine, Abu Dis-Jerusalem, Palestine.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180831
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO)
RN  - EC 1.14.11.33 (FTO protein, human)
SB  - IM
MH  - Alleles
MH  - Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*genetics
MH  - Arabs/*genetics
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Variation/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/genetics
MH  - Risk
PMC - PMC6119238
OTO - NOTNLM
OT  - BMI
OT  - FTO
OT  - Palestine
OT  - T2DM
OT  - rs9939609 variant
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: All the study procedures were 
      approved by the Ethics Committee of Al-Quds University (Rf no. 2/SRC/4). Informed 
      consent was obtained from all individual participants included in the study. 
      CONSENT FOR PUBLICATION: Written consent was obtained from all participants to 
      publish their data. COMPETING INTERESTS: The authors declare that they have no 
      competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with 
      regard to jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/09/02 06:00
MHDA- 2019/04/16 06:00
PMCR- 2018/08/31
CRDT- 2018/09/02 06:00
PHST- 2018/05/01 00:00 [received]
PHST- 2018/08/17 00:00 [accepted]
PHST- 2018/09/02 06:00 [entrez]
PHST- 2018/09/02 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
PHST- 2018/08/31 00:00 [pmc-release]
AID - 10.1186/s12881-018-0668-8 [pii]
AID - 668 [pii]
AID - 10.1186/s12881-018-0668-8 [doi]
PST - epublish
SO  - BMC Med Genet. 2018 Aug 31;19(1):156. doi: 10.1186/s12881-018-0668-8.